vhl

Conclusion Imaging techniques still play an important role in the evaluation and management of VHL disease .

结论影像学检查在冯·希佩尔·林道病的诊治中仍起着极其重要的作用。

Expression of VHL and HIF-1 α and its clinical significance in the lung cancer tissue

肺癌组织中VHL和HIF-1α表达及其临床意义

Objective To discuss imaging features of von Hippel-Lindau disease ( VHL disease ) .

目的探讨vonHippel-Lindau病（VHL病）的影像学特征。

Somatic mutations of VHL gene and HIF-1 α expression in primary renal clear cell carcinomas

肾透明细胞癌中VHL基因突变与缺氧诱导因子-1α表达的研究

The mutations of VHL gene were irrespective of the age and pathological grade and stage of patients .

结论：国人非遗传性肾透明细胞癌中存在VHL基因的突变，且与患者年龄，肿瘤分期、分级无相关性。

The detection of mutations in VHL gene from a single cell in a patient with von Hippel-Lindau disease

单细胞水平检测vonHippel-Lindau病基因突变的实验研究

Results Combining with the familial history , individual history , radiology and pathology , the diagnosis of VHL can be made .

结果结合家族史、个人史、影像学检查以及手术病理证实其诊断。

Role of hypoxia inducible factor-1 α and VHL in murine endochondral ossification

低氧诱导因子-1α和VHL对小鼠软骨内成骨过程的调控机制

The VHL gene may be useful as a marker gene for the diagnosis of RCC and as a target gene for molecular therapy .

VHL基因可作为临床诊断指标，并可望成为肾透明细胞癌基因治疗的重要目的基因。

Objective To evaluate the imaging manifestation of von Hippel Lindau ( VHL ) disease .

目的评价冯·希佩尔·林道病的影像学表现。

Mutation of VHL gene from tumor tissue was detected from tumor tissue by polymerase chain reaction ( PCR ) and direct sequencing .

采用单链聚合酶链反应（PCR）和测序法检测肿瘤组织中VHL基因的突变情况。

Analysis of biallelic inactivation of the von Hippel-Lindau tumor suppressor gene VHL in patients of renal cell carcinoma patient

肾细胞癌患者抑癌基因VHL双等位基因失活的测定

These mutations mainly occurred in the last one-third region of exon 1 , 2 and 3 of the VHL gene .

这些突变主要发生在第1,2,3号外显子的后1/3区，其中6例缺失，2例插入，3例误义突变。

Mutation and hypermethylation of VHL gene in angioreticuloma

血管网织细胞瘤中VHL基因突变与异常甲基化检测

[ Objective ] To explored the VHL gene mutation in HCC and its relations with VEGF , MVD and its clinic-pathological features .

研究人肝细胞癌与VHL基因突变的关系以及VHL基因突变肝细胞癌与VEGF、血管密度（MVD）及临床病理特征之间的相互关系。

Objective : This paper was designed to detect von Hippel Lindau ( VHL ) gene mutation in the paraffin embedded renal carcinoma specimens .

目的：研究石蜡包埋肾肿瘤标本VHL基因突变情况。

VHL disease ( von Hippel-Lindau disease ) is a kind of hereditary cancer syndrome associated with the mutation of VHL anti-oncogene .

VHL病（vonHippel-Lindaudisease）是一种遗传性肿瘤综合征，由VHL抑癌基因突变引起。

Results VHL gene mutation was detected in 10 ( 35.7 % ) CCRCC tumor samples . There was no mutation detected in all normal kidney tissues .

结果远离肿瘤的正常肾组织中未检测到VHL基因的突变，10例（35·7%）癌组织标本中存在VHL基因的突变。

Objective : To detect the expression of hypoxia-inducible factor 1 alpha ( HIF-1 α), p53 , PTEN and VHL in breast cancers and study their relationship .

目的：研究乳腺癌组织中p53、PTEN、VHL、HIF-1α的表达及其相互关系，并探讨其意义。

Conclusion VHL disease is a heritance family multi systems neoplasm syndrome . Familiarity with the imaging features of VHL will be helpful to the accurate diagnosis .

结论VHL病为家族性遗传性多系统肿瘤综合征，熟悉其影像学表现有利于正确诊断。

Conclusion VHL gene aberration is not only responsible for the pathogenesis of VHL disease , but also an important pathogenetic basis for sporadic ELST .

结论VHL基因的异常导致其功能改变不但是VHL的致病原因，而且是散发性内淋巴囊瘤发病的重要的基因遗传学基础。

Conclusion Biallelic inactivation of VHL gene occurs in RCC due to VHL mutation and LOH , and its frequency rate is37 % .

结论肾细胞癌中存在由VHL基因突变和LOH导致的VHL双等位基因失活现象，VHL双等位基因失活发生率为37%。

Objective To investigate the mutation of Von Hippel-Ldau ( VHL ) tumor suppressor gene in peatients with primary sporadic human renal cell carcinoma ( RCC ) .

目的探讨国人原发性散发性肾透明细胞癌中VHL抑癌基因突变及其意义。

Methods : The hypermethylation was examined by methyl sensitive restrictive DNA endoenzyme analysis in 34 cases of angioreticuloma and the VHL gene mutations detected by PCR SSCP analysis .

方法：采用PCRSSCP法检测血管网织细胞瘤中VHL基因的突变率及甲基化，敏感限制性内切酶消化法检测血管网织细胞瘤中VHL基因的异常甲基化率。

Conclusions The renal lesions in VHL disease include both cysts and carcinomas , which are often multifocal and bilateral . Almost all the tumors are of clear cell type with a low stage and grade .

结论VHL病中肾脏损害包括肾癌及肾囊肿，常为双侧多发性，肿瘤为透明细胞癌且分级分期低。

Conclusion LOH of VHL gene is an important genetic event in Chinese sporadic renal carcinoma , and the LOH frequency is 41.4 % . VHL LOH has no influence on stage and grade of RCC .

结论在散发性肾癌中，VHL基因LOH是肿瘤发生的重要机理，其发生率达41.4%，VHL基因LOH与肾癌分期、分级无关。

Results : The number of the cases of decannulation was 97 , from 8 days to 1 year after operation , 11 cases without decannulatin ( VHL 6 , HHL 2 and OHL 3 ) .

结果术后拔管97例，拔管时间8d至1年，未拔管11例（垂直半喉6例，水平半喉2例，超半喉3例）。

Insulin-like growth factor-I receptor ( IGF-IR ) which is one of RTK family member has an intimate relationship with genes such as VHL and TGF - β . Researches of IGF-IR inhibitors have made progress in other tumors .

胰岛素样生长因子-1受体（insulin-likeGrowthFactor-Ireceptor，IGF-IR）作为RTK家族成员，其在肾癌中与VHL、TGF-β等基因关系密切，IGF-IR抑制剂在其它肿瘤治疗中已取得一定进展。