nacc

Inhibitory effect of ethanol of three concentrations on the evoked potential of neurons in NAcc

三种浓度的酒精对大鼠伏核神经元传入电活动的抑制作用

Effects of Three Opioid Receptor Agonists on the Evoked Potential of NAcc Neurons in Rats in Vitro

阿片受体激动剂对离体大鼠伏核神经元传入电活动的抑制作用

Objective : To study the effect of ethanol on the neurons in NAcc and explore the mechanisms of ethanol dependence .

目的··：研究酒精对伏核神经元的影响，初步探讨酒精依赖的生物学机制。

These results suggest that opioid pep & tides predominantly reduce synaptic transmission in NAcc .

上述结果提示：在伏核内，阿片肽的作用在于降低突触传递。

Alcohol could stimulate the Nacc to produce reward effect , and this is the positive reinforcement of alcohol addiction .

酒精可以影响伏核以产生奖赏效应，形成正性强化因素而造成酒精成瘾；同时，酒精也可以对背侧纹状体产生作用以影响和成瘾有关的服药行为和寻药行为的建立。

Conclusion : LAAO of king cobra venom can induce the apoptosis of NACC cells .

结论：眼镜王蛇毒LAAO能诱导NACC细胞发生凋亡。

The effect of LAAO induced-apoptosis on NACC cells was observed in different concentrations by inverted phase contrast microscope , H.E.

用倒置显微镜观察、H.E。

Only lesion of the NAcc core , but not shell , can reduce the re-acquisition of morphine-seeking behavior .

只有核心部毁损能够减少吗啡成痛之后的复吸行为。

OBJECTIVE To investigate the effects of Radix Astragali injection on novel human palatal salivary gland cell line of adenoid cystic carcinoma ( NACC ) in vitro .

目的研究黄芪注射液对人类小涎腺腺样囊性癌（NACC）细胞株的抑制作用。

AIM : To investigate the function of the nucleus accumbens ( NAcc ) core or shell in drug seeking behavior and the effects of NAcc core or shell lesion on drug addiction .

目的：分析伏隔核各亚区（外壳、核心）在吗啡觅药行为中的作用，研究定向毁损对大鼠成瘾行为的影响。

To investigate the neural mechanism in the ethanol dependence , the alteration of the EEG and power spectra in rat nucleus accumbens ( Nacc ) on the chronic ethanol exposure and withdrawal was analysed .

观察慢性酒精刺激过程中大鼠伏核EEG及功率谱的变化，探索酒精依赖的神经机制。

RESULTS After treatment with ~ 0.065 g · mL ~ - 1 Radix Astragali injection for 48 hours , the growth of NACC cells was inhibited by 8 % and markedly induced the apoptosis of NACC cells .

结果研究发现作用48h后，黄芪浓度为0.065g·mL-1时已对体外培养的细胞株有抑制作用，NACC抑制率达8%，可高度诱导NACC细胞的凋亡。

[ Methods ] The adenosine triphospate ( ATP ) - bioluminescence tumor chemosensitivity assay ( ATP-TCA ) was used to examine the growth of NACC cells treated with in Guangxi cobra venom different concentration .

方法以不同浓度的眼镜蛇毒作用于NACC细胞，应用三磷酸腺苷-生物荧光肿瘤化疗药物敏感试验法（ATP-TCA法）测定细胞的增殖状态；

Results After injected morphia into side-ventricle , the frequence of PEN ( pain-excitatory neurons ) discharge in normal neuron accummbens ( Nacc ) and medial septal diagonal band complex increased , while the firing of PIN ( pain-inhibitory neurons ) decreased .

结果侧脑室注入盐酸吗啡后可使大鼠伏隔核及内侧隔-斜角带核痛兴奋神经元（PEN）电活动增加，使痛抑制神经元（PIN）电活动减少。