mpag

Determination of MPA 、 MPAG in Human Plasma & Correlation Study between Their Pharmacokinetic Parameters and Clinical Events in Chinese Renal Transplant Patients Treated with Oral MMF

中国肾移植患者口服骁悉后体内主要代谢产物MPA、MPAG的血药浓度测定及其药代动力学与临床疗效、毒副反应的相关性研究

Objective : To establish a method for determining mycophenolic acid ( MPA ) and its glucuronide ( MPAG ) inhuman plasma .

目的：建立霉酚酸（MPA）及其葡糖苷酸（MPAG）血药浓度测定方法。

AIM To establish a method for determination of mycophenolic acid ( MPA ) and MPA-glucuronide ( MPAG ) in human urine by HPLC .

目的用HPLC测定人尿液中霉酚酸（MPA）及其代谢物葡糖苷酸结合物（MPAG）的浓度。

OBJECTIVE To establish a HPLC method for determining total and free concentration of mycophenolic acid ( MPA ) and its glucuronide ( MPAG ) in human plasma .

目的建立HPLC测定人血浆中总的和游离麦考酚酸（MPA）及其代谢物葡糖苷酸结合物（MPAG）含量的方法。

Purpose To investigate the pharmacokinetics ( PK ) characteristics of total and free mycophenolic acid ( MPA ) and its glucuronide metabolite ( MPAG ) in renal transplant recipients at steady state .

目的探讨肾移植患者中麦考酚酸（MPA）及其葡萄糖苷酸代谢物（MPAG）的药动学特征。