lck

Effect of IL-2 on Lck expression in renal tubular epithelial cells

白细胞介素2对淋巴细胞特异性蛋白酪氨酸激酶在肾小管上皮细胞中表达的影响

Investigation of lck on IL 12 signal transduction in tubular epithelial cells

Lck对肾小管上皮细胞的IL-12信号传递功能研究

Fluorescence Resonance Energy Transfer Evidence of Direct Interaction Between PKC ε and Lck in vivo

PKCε与Lck在细胞内直接相互作用的荧光共振能量转移证据

Role of lck / p38 signaling pathways in murine renal tubular epithelial cells

淋巴细胞特异蛋白质酪氨酸激酶/p38信号传递途径在小鼠肾小管上皮细胞的作用

Objective To investigate the effect of lck pathway activation on IL 12 signal transduction of the tubular epithelial cells .

目的研究lck途径激活后对小鼠肾小管上皮细胞的信号传递功能的影响。

Association between the polymorphisms of lymphocyte-specific protein tyrosine kinase ( LCK ) gene and AD

淋巴细胞特异性酪氨酸蛋白激酶基因多态性与阿尔茨海默病的相关性研究

The research shows that Lck plays a very important role in mediating TCR signal transduction and the development , differentiation , proliferation and activation of T cells .

研究显示，Lck对于介导TCR信号转导过程及细胞的发育、分化、增殖和激活具有十分重要的作用。

Through comparing with the primary sequence of Lck amino acid in species of different stages from lower to higher level , the phylogenetic tree has been constructed based on neighbouring and other methods .

将其与从低等到高等不同进化阶段的物种的Lck氨基酸一级序列进行比对分析，基于邻接法等构建了系统发育树。

Results : The tumor volume and cell load were all differential significantly in each gade of WHO response . The relation between the WHO criteria and the LCK has been defined .

结果：每级别WHO疗效在相同或不同大小肿瘤都存在体积、细胞负荷和LCK的显著差异，WHO疗效评价与LCK相互换算关系得到确定。

Aim To investigate whether there is IL-12 signaling pathway through lck / p38 / c - jun in splenic cells obtained from lupus mouse and its effect on splenic cells .

目的探讨在狼疮小鼠脾细胞中是否存在IL－12通过Lck／P38／c－jun传递信号及其对脾细胞的影响。

The objective of this study was to investigate the correlation of WHO criteria with the tumor volume , the tumor cell load and the LCK ; and the necessity developing a method to measure LCK quantitatively .

本研究目的是探讨WHO疗效标准与肿瘤体积或细胞负荷及细胞对数杀灭（logcellkill，LCK或LK）相互关系及提出细胞对数杀灭定量评价方法的必要性。

Lck kinase is a member of the Src family of non-receptor protein tyrosine kinases , which is expressed primarily in T lymphocytes and plays an important role in T cell activation and development .

Lck激酶是非受体蛋白酪氨酸激酶Src家族的成员之一，特异性地在T淋巴细胞中表达，并且在T淋巴细胞的活化及发育过程中发挥着重要作用。

An agent inhibiting lck would block T cell function effectively . Act as an immunosuppressive agent , it has potential utility in autoimmune diseases , the transplant rejection , allergic diseases as well as cancers .

抑制lck活性能有效地阻断T细胞的功能，针对lck激酶的抑制剂作为一种免疫抑制剂，可用于治疗自身免疫性疾病、移植排斥、过敏性疾病和多种癌症。

Objective : The objective of this experiment was to construct recombinant adenoviral vector expressing antisense RNA to Lck gene , and investigate its effect on Lck protein expression in renal tubule epithelial cells ( TEC ) .

目的：观察淋巴细胞特异性蛋白酪氨酸激酶（Lck）在肾小管上皮细胞中的表达及Lck反义RNA对其表达的影响。

Conclusion : WHO response criteria can not determine the tumor volume , the cell load as well as the LCK . A new method evaluating LCK quantitatively has been proposed and it may be interconverted with WHO response criteria .

结论：WHO标准不能定量评价肿瘤体积、细胞对数和LCK，提出可与WHO疗效评价相互换算的LCK定量评价方法非常必要。

Conclusion IL-12 , IL-2 and LPS may promote lck gene express in renal tubular epithelial cells and only IL-12 can induce p38 phosphorylation through lck uniquely , and they can play biologic role in renal tubular epithelial cells via lck / p38 signaling pathways .

结论IL－12、IL－2、LPS促进肾小管上皮细胞中lck基因表达，并只有IL－12唯一通过lck诱导p38磷酸化，它们皆可通过lck／p38信号传递途径参与对肾小管上皮细胞发挥生物学作用。