ipk

Expression , purification and identification of recombinant GST-P58 ~ ( IPK ) fusion protein

GST-P58~（IPK）融合蛋白的表达、纯化及活性鉴定

These results suggested that the reduction of release or the increase of breakdown of EDRF might be of an important significance in CsA induced acute IPK hemodynamic disturbance .

结果提示EDRF释放减少或灭活增多在CsA引起的IPK急性血流动力学障碍中可能具有重要意义。

Conclusion it is proved in IPK model that the generation of ONOO ~ ( - ) possesses important role in renal vascular response damage of rats after renal I-R.

结论ONOO-在肾I-R所致的肾血管反应性损伤中具有重要的作用。

The model of CsA induced IPK acute hemodynamic disturbances was used to explore the possible role of endothelium derived rived relaxing factor ( EDRF ) in mediating CsA induced nephrotoxicity .

利用环孢素A（CsA）致大鼠离休灌注肾急性血流动力学障碍模型研究了内皮源性舒张因子（EDRF）在CsA致肾毒性发生中的作用。

The preventive effect of tetramethylpyrazine ( TMP ) on the cyclosporine A ( CsA ) induced nephrotoxicity was studied in the experimental model of CsA induced acute hemodynamic disorder of isolated perfused rat kidney ( IPK ) .

本研究应用环孢素A（CsA）致大鼠离体灌注肾急性血流动力学障碍模型，研究了川芎嗪对CsA肾毒性的防治作用。

Aim To establish a in vitro model for discovery and evaluation of uricosuric drug , we established a reliable rat isolated perfused kidney ( IPK ) preparation and observed urate excretion characterization in absence or presence of probenecid in perfusate by IPK .

目的为建立发现和评价促尿酸排泄药物作用的离体模型，采用离体大鼠肾脏灌流技术，观察尿酸在离体肾脏中排泄特点和丙磺舒对尿酸排泄影响。