icos

The role of ICOS in hematopoietic stem cell transplantation

可诱导共刺激分子在造血干细胞移植中的作用

New Research on the Relationship Between Exercise and Th Cell and ICOS

运动与Th细胞和ICOS分子研究新进展

Construction and identification of human ICOS extracellular domain gene recombinant adenovirus

人ICOS胞外区腺病毒载体的构建与鉴定

And the application of RTOS make ICOS highly portable .

另外，RTOS在ICOS中的应用使得应用程序的移植变得容易，加快了开发的速度。

As a result the potential applications of ICOS has drawn extensive attention and interesting of people .

其潜在的应用前景引起了人们的广泛关注。

Establishment of the ICOS Transgenic Mice Model and Its Application to the Study of Schistosomiasis Japonicum

ICOS转基因小鼠模型的建立及其在日本血吸虫病研究中的应用

B7 and ICOS mRNA expression in human colorectal carcinoma

人结直肠癌组织中B7和ICOS分子mRNA的表达

Stable expression of ICOS / Fc in CHO cells

ICOS/Fc在CHO细胞中的稳定表达

Influence of dendritic cells modified with ICOS extracellular region on survival of renal allografts in rats

ICOS胞外区基因修饰的树突状细胞对移植肾存活的影响

ICOS : a new important costimulatory molecule

ICOS：一种重要的新型诱导共刺激分子

The serum IgG and IgG1 in ICOS transgenic mice were also significantly higher than those in control .

转基因小鼠血清IgG、IgG1表达水平也均高于对照组。

Preparation of New Co-stimulatory Molecule ICOS / GL50 and Study on Their Biological Characteristics as Well as Application

新型共刺激分子ICOS/GL50的研制和生物学特征及运用的研究

Expression of ICOS in the liver of BXSB mice

BXSB小鼠肝脏可诱导共刺激因子的表达

This research tries to establish the ICOS transgenic mice model and applies it to the study of schistosomiasis Japonicum .

本课题尝试建立ICOS转基因小鼠模型，将其应用于日本血吸虫病的研究。

The role of ICOS co-stimulatory passageway on corneal transplantation rejection

ICOS共刺激通路参与角膜移植免疫排斥反应的研究

The establishment of ICOS transgenic mice

诱导性免疫共刺激分子转基因小鼠模型的建立

Results Three RNA interference retrovirus vectors based on bidirectional promoter were constructed and one of them can suppress ICOS expression effectively .

结果构建了针对ICOS三段序列的逆转录病毒干扰载体MIW-ICOS，并证实其中的一个干扰载体能有效抑制ICOS的表达。

Function of ICOS / B7RP-1 costimulation in chronic allograft nephropathy of rat

ICOS/B7RP-1共刺激通路在大鼠慢性移植物失功中作用的研究

CONCLUSIONS : The whole blood gene expression quantities of costimulatory molecules CD154 and ICOS reasonably robustly differentiated rejection patients from control patients .

结论：共刺激分子CD154和ICOS的全血基因表达量能可靠的区分排异患者和对照患者。

The result of Western blotting showed that the dynamic changes of ICOS protein was identical with the changes of positive-cell number detected by immunohistochemistry .

Western-blotting检测结果显示，ICOS蛋白的动态变化与免疫组织化学显示的阳性细胞数量变化一致。

Egg Granulomatous Formation of Liver and Molecule Mechanism in Transgenic Mice of Inducible Costimulatory Molecule ( ICOS ) Infected with Schistosoma Japonicum

日本血吸虫感染共刺激分子ICOS转基因小鼠免疫病理及分子机制

Full-length of ICOS was amplified through RT-PCR from activated human T cells and the cDNA fragment was cloned into T-vector plasmid .

采用RT-PCR法从活化的人T细胞中扩增了ICOS全长基因，装入T-vector克隆载体。

The percentage of CD28 + ICOS + cells on the peripheral blood CD4 + T cells in untreated primary patients was higher than those with disease relapse ;

初发未治疗SLE病人仅CD4+T细胞中CD28+ICOS+细胞的比例比复发病人明显升高；

The level of ICOS expression on the peripheral blood CD45RO + cells in the untreated primary patients was higher than those with disease relapse ( P < 0 05 );

初发SLE患者CD45RO+细胞表达ICOS水平明显高于复发患者（P<005）；

Objective To investigate the expression of inducible co-stimulator ( ICOS ) on T lymphocytes in peripheral blood from the patients with systemic lupus erythematosus ( SLE ) .

目的探讨可诱导共刺激分子（ICOS）在系统性红斑狼疮（SLE）患者外周血T淋巴细胞的表达。

Objective To construct retrovirus vectors expressing siRNA for ICOS by bidirectional promoter RNA interference techno - ( logy ), and study its suppressing effect on ICOS .

目的应用双向启动子技术构建针对共刺激分子ICOS的逆转录病毒干扰载体，观察其对ICOS表达的影响。

Immunohistochemical staining was performed using polyclonal antibodies to ICOS on the sections of the spleen which were obtained from the rats in immune group at the 7th , 12th , 15th and 21st days after immunisation respectively .

免疫组大鼠分别于免疫后第7、12、15、21天被处死，摘除其脾脏后制作冰冻连续切片并提取组织蛋白。

It is well-accepted that GL50 / ICOS signal pathway plays a pivotal role in the regulation of inflammatory responses , in the prevention of transplantation rejection and tumor development , as well as in the modulation of autoimmune diseases .

目前的研究业已证明：GL50-ICOS信号途径在机体炎症、自身免疫性疾病、肿瘤和移植排斥等免疫应答过程中发挥着重要的调节作用。

To investigate the characteristics and biological functions of ICOS expression as well as its inherent relationships to such factors as stress response and T-cell activation at cell level by means of incubation of T-cells of healthy adults peripheral blood cells in vitro . 2 .

研究目的：1、通过普通健康人外周血T细胞的体外实验，研究和探讨ICOS分子的表达特征及生物学功能，从分子水平揭示应激激素、T细胞活化、ICOS分子表达之间的内在联系。

Conclusions ICOS-2394C / T , - 2119C / T and CD_ 24 E2 + 226C / T polymorphisms are related with MS in Chinese Han people , either ICOS or CD_ 24 or both being one of the genes susceptible to MS or linking with susceptible genes .

结论中国汉族人群ICOS-2394C/T、ICOS-2119C/T及CD24E2+226C/T多态性与MS发病相关，两基因可能均是MS的易患基因或与易患基因相连锁。