enac

Objective To observe epithelial sodium channels ( ENaC ) currents in spermatogenic cells .

目的研究记录小鼠生精细胞上表皮钠通道电流。

Present Condition of the Studies of the Epithelial Na ~ + Channel ( ENaC ) and its Genes

上皮细胞钠离子通道ENaC及其基因研究现状

Gain-of-function mutations in ENaC genes cause an infrequent hereditary hypertension & Liddle syndrome ;

功能获得性ENaC基因突变可引起一种罕见的遗传性高血压&Liddle综合征；

Objective To investigate the distribution and its significance of α,β and γ subunits of epithelial sodium channel ( ENaC ) in the rat vestibule .

目的研究大鼠前庭组织中上皮钠通道α、β、γ亚基的表达及其意义。

Research revealed that the alveolar liquid clearance mainly depends on the Na ~ + transport mediated by alveolar epithelial Na ~ + channels ( ENaC ) .

研究认为肺泡内液体的清除主要依赖肺泡上皮钠通道介导的Na~+离子转运。

The Relevance between the Mechanism of Terbutaline Enhancing Oleic Acid-induced Acute Lung Injury Adult Rat Pulmonary Alveolar Edema Clearance in Short Time and α ENaC Subunit

特布他林短时间作用促进油酸急性肺损伤大鼠肺泡液清除的机制与αENaC的相关性

ENaC is responsible for the rate-limiting step of sodium reabsorption and thus plays an important role in the maintenance of sodium balance , extracellular fluid volume and blood pressure .

ENaC负责钠离子的限速重吸收，对于维持钠的自身平衡、细胞外液量和血压起重要作用。

Conclusion Analysis of the gene encoding β ENaC identified a mutation at codon 616 . A direct DNA sequencing analysis diagnosed Liddle ′ s syndrome in four siblings at gene level .

结论同一个家系中的4例高血压同胞检出βENaC基因突变，在基因水平上确诊为Liddle综合征。

IL-4 and IL-6 were added to the primary cultured human bronchial epithelial cells , and reverse transcriptase-polymerase chain reaction ( RT-PCR ) was preformed to detect mRNA of ENaC subunits α,β and γ .

用IL-4、IL-6处理原代培养人气道上皮细胞，逆转录-聚合酶链反应（RT-PCR）技术半定量检测ENaC三个亚单位α、β、γ的mRNA水平。

Purpose To investigate the expression of lung aquaporin 1 and 5 ( AQP1 , AQP5 ) and epithelial sodium channel ( ENaC ) at mRNA level in two kinds of rat congestive heart failure models .

目的研究在不同程度的充血性心力衰竭时肺脏水通道蛋白1和5（AQP1、AQP5）和上皮性钠通道（ENaC）表达的情况。

Essential hypertension is a kind of complex disease cooperated by genetic factors and environmental factors , ENaC genes are given more attention as candidate gene of essential hypertension because of its important role in maintenance of sodium homeostasis and blood pressure .

原发性高血压是受遗传因素和环境因素共同影响的复杂性疾病，由于ENaC的维持钠的自身平衡和血压的重要作用，因此ENaC基因作为原发性高血压的候选基因而备受关注。