eae

Conclusion The construction of EAE animal model was stable and reliable .

结论本实验所构建的EAE模型稳定、方法可靠。

Study on Immunological Mechanism in EAE Rat Regulated by T Cell Vaccination

T细胞疫苗接种对实验性自身免疫性脑脊髓炎大鼠免疫机制的调节作用

Extraction and Identification of MBP and the Establishment of EAE Model

MBP的提取、鉴定及EAE模型的建立

Objective To explore the possible causes of MBP inducing EAE .

目的探讨髓磷脂碱性蛋白（MBP）诱导EAE产生的可能原因。

The changes of expression of MMP-2 and MMP-9 in different course of EAE

MMP-9和MMP-2在多病程大鼠EAE发病过程中的变化

Conclusion Dexamethasone could enhance apoptosis of thymocyte in EAE mice .

结论地塞米松可明显增强EAE小鼠胸腺细胞凋亡。

Objective Establishment of myelin proteolipid protein induced EAE animal model .

目的用髓鞘蛋白脂质蛋白多肽（PLP）139-151诱发实验性自身免疫性脑脊髓炎（EAE）小鼠模型。

Result EAE model showed typical clinical situation 、 pathological change and ultrastructure of EAE .

结果所建立的EAE动物模型的临床表现、病理改变、超微结构变化等方面均符合EAE的表现。

Experimental Treatment of EAE by Phage Small Peptides Containing VCAM-1 Core Epitope

VCAM-1核心表位的噬菌体短肽用于EAE的实验性治疗

The detection and significance of ICAM-1 and VCAM-1 in EAE rat brain

EAE大鼠脑中ICAM-1、VCAM-1的检测及意义

The study of experimental intervention on apoptosis of the cerebral white matter cells in EAE guinea pigs

实验性变应性脑脊髓炎脑白质细胞凋亡的实验性干预研究

Results Immunohistochemistry showed specific MMP-9 expression in EAE brain and spinal cord by contrast to control model .

结果经免疫组化方法检测结果显示EAE大鼠脑脊髓内有特异的MMP-9表达，与对照组比较差异有显著性。

The findings may play an important role in studying immunological mechanism of EAE or MS in the future .

此结果对今后研究EAE或MS的免疫学机制可能有重要指导作用。

A Study of Cell Apoptosis in the Central Nervous System and the Peripheral Lymphoid Organs in EAE Rats

EAE大鼠中枢神经系统与外周免疫器官细胞凋亡的研究

Objective : To study the curative effect of EAE with DT390-IL2 recombinant plasmid .

目的：研究DT390-IL2重组质粒对实验性变态反应性脑脊髓炎（EAE）的治疗效果。

Methods The female guinea pigs were divided randomly into control group , EAE group and i.p.MBP group .

方法将雌性豚鼠随机分为对照组、EAE组和腹腔注射MBP组。

Typing of eae gene in Escherichia coli strains with LEE pathogenicity island isolated in China

我国stx~-大肠埃希菌eae基因分型的研究

Objective To explore the regulating effect of T cell vaccination on experimental autoimmune encephalomyelitis ( EAE ) model .

目的探讨T细胞疫苗（TCV）接种对实验性自身免疫性脑脊髓炎（EAE）免疫机制的调节作用。

EAE the one that should be jealous .

你才是那个该吃醋的人。

However , the activation of microglia in acute episode of EAE was most obviously .

小胶质细胞的活化增殖在EAE急性期表现最为明显，缓解期和复发阶段均有活化现象的存在；

Objective : To induce a meliorative model of experimental allergic encephalomyelitis ( EAE ) .

目的：提取并纯化正常人脑脊髓的髓磷脂碱性蛋白（MBP），鉴定其活性，并用其诱导实验性自身免疫性脑脊髓炎（EAE）大鼠模型。

Pertussis is important in EAE induction in un-susceptive Wistar rats and different injection places had different results .

百日咳对EAE非敏感品系WIStar大鼠诱导EAE模型有重要作用，不同的注射部位对发病率有明显的影响。

Role of the Cell-Mediated Immunity in Onset of EAE

细胞介导免疫在EAE发病中的作用

The behavior and the pathological changes of brain and spine cord of rats were observed to ascertain EAE model successful .

通过观察大鼠行为学及脑和脊髓的病理改变确定EAE。

Therapy of EAE rats by methyl-vitamin B12 and the changes of lysophosphatidic acid levels

甲基维生素B12对大鼠自身免疫性脑脊髓炎的治疗及溶血磷脂酸水平的影响

The results showed that high dose of Duhuo inhibited the proliferation obviously ( P0.05 vs EAE model group ). 3 .

结果显示：高剂量组独活能显著抑制淋巴细胞的增殖，与EAE模型组比较差异显著（P0.01）。

Conclusion the level of CD4 + / CD8 + and IL-6 in peripheral blood rats may play an important role in EAE .

结论外周血CD4+/CD8+比值及IL-6水平增高在大鼠EAE的发生过程中发挥重要作用。

Conclusions It is suggested that apoptosis may be a major clearance process of infiltrated cells in the CNS of EAE .

结论细胞凋亡是EAE动物CNS中浸润细胞的重要清除方式。

Compared with EAE model group , ultrastructural changes of myelin and axon in MMF treated group were relieved .

电镜结果示，MMF治疗组髓鞘与轴突的超微结构改变较EAE模型组明显减轻。

EAE is a T-cell-mediated demyelinating disease of CNS and a typical model of MS.

EAE是T细胞介导的CNS脱髓鞘疾病，是MS的经典动物模型。