cyp3a4

This review is about the gene mutation and phenotype of CYP3A4 .

本文对CYP3A4基因突变及其表型特征加以总结。

Further understanding of this interaction would be potentially useful to improve oral bioavailability of CYP3A4 / P-glycoprotein substrates .

进一步了解两者的相互作用有助于改善CYP3A4/P糖蛋白底物的生物利用度。

AIM : To investigate the stereoselective metabolism of propafenone ( PPF ) by human liver CYP3A4 .

目的：研究普罗帕酮（PPF）经人肝CYP3A4代谢的立体选择性。

Co-administration of potent CYP3A4 inducers may decrease concentrations of ISTODAX and should be avoided .

联合CYP3A4的诱导剂烈性政府可能减少ISTODAX浓度，应当避免。

Grapefruit juice can reduce the risk of cancer incidence because it is the principle of a substance which can prevent the formation of the enzyme CYP3A4 .

柚子汁可以减少癌症发病几率的原理是因为它里面的一种物质可以阻止CYP3A4酶的形成。

Lab studies suggest that black mulberry juice , wild grape juice , pomegranate juice , and black raspberry juice also interfere with CYP3A4 .

实验室研究表明黑果桑木汁、野葡萄汁、石榴汁和黑莓汁也影响CYP3A4。

ResultsSome Chinese herbal medicine can reduce or induce CYP3A4 isoform of cytochrome P450.Consequently it affected combined drug metabolism and resulted in drug interaction .

结果多种中草药及成分能够抑制或诱导细胞色素CYP3A4亚型，从而影响合用药物的代谢，导致药物相互作用的发生甚至不良反应的发生。

In this study , we first hypothesized that DEX potentiates CPA toxicity by inducing CYP3A4 and therefor changing its metabolic fate and pharmacokinetics .

在本研究中，先假设DEX通过诱导CYP3A4而改变CYP的两条代谢途径的相对比例，并使其药代动力学发生改变，从而增加CPA的毒性。

One glass of grapefruit juice , or eating half a grapefruit , is enough to suppress CYP3A4 activity by half , and the effect lasts up to24 hours .

一杯葡萄柚汁或吃半个葡萄柚足够抑制CYP3A4活性的一半，并且这种效应持续达24小时。

Objective To investigate the influence of dodder on the activities of cytochrome P450 ( CYP450 ) system : CYP1A2 , CYP2D6 , and CYP3A4 in rat liver microsome .

目的观察菟丝子对大鼠肝细胞色素P450酶系统中CYP1A2，2D6以及3A43种亚型活性的影响。

Grapefruit contains a type of chemical called furanocoumarin ( also found in seville oranges and limes but not valencia or other sweet oranges ) , which , by inhibiting the enzyme CYP3A4 , stops the breakdown of some prescription drugs .

葡萄柚含有一种叫做furanocoumarin的化学物质（还发现在塞维利亚橘子和酸橙中但不是瓦伦西亚或其他甜橙），通过抑制CYP3A4这种酶可以阻止一些处方药的分解。