bmk

Studies of BmK on inhibition of cell growth and induction of apoptosis in leukemic Raji cell line

蝎毒对白血病Raji细胞株的生长抑制和诱导凋亡作用的研究

Objective : The study of the BMK on inhibition of cell growth and induction of apoptosis in Yac-1 cell line .

目的：研究蝎毒对小鼠淋巴瘤细胞株的生长抑制和诱导凋亡作用。

Primary study of BmK on reversal of multidrug resistance in k562 / adm cell line

蝎毒逆转K562/ADM细胞多药耐药性的初步研究

Studies on Insect Resistance of Transgenic Tobacco Plants Carrying the BmK IT_4 Gene

转BmKIT4基因烟草的抗虫性

Characteristics of BmK AS Binding to Rat Brain and Cockroach Nerve Cord Synaptosomes

BmKAS在大鼠脑和蟑螂神经索突触体上的药理结合特性

Effects of BmK AS-1 on TTX-R Sodium Channel Currents in Rat DRG Neurons

东亚钳蝎毒素多肽纯化组份BmKAS-1对大鼠背根神经节神经元河豚毒素不敏感型钠通道电流的作用

Effect of Inducing Apoptosis and Resistance Reversing of BMK Combined with ADM on Human Breast Cancer MCF-7 / ADM Cell Line

蝎毒联合ADM对人乳腺癌MCF-7细/胞的凋亡诱导作用及其耐药逆转的研究

The insect resistance and yield traits in six transgenic cotton Studies on Insect Resistance of Transgenic Tobacco Plants Carrying the BmK IT_4 Gene

以美国转基因抗虫棉（CK1）和泗棉3号（CK2）为对照，研究了6个转基因皖棉品系的抗虫性和产量性状。转BmKIT4基因烟草的抗虫性

CoMparison of analgesic effect of scorpion venom from Buthus martensii Karsch ( BmK ) with

东亚钳蝎毒素的镇痛作用与吗啡镇痛作用的比较

BMK ( 3 μ g / mL ) could significantly decrease glutathione s-transferase activity in MCF-7 / ADM cells ( P0.01 ) .

蝎毒（3.0μg/mL）显著降低耐药细胞内谷胱甘肽S转移酶的活性（P0.01）。

It indicates that there are special target receptors for BmK AS type scorpion neurotoxins on both mammal and insect excitable cell membranes .

结果提示，BmKAS类蝎神经毒素在哺乳动物和昆虫兴奋性细胞膜上存在着特异的靶受体。

Advance of neurotoxin from scorpion BmK

东亚钳蝎神经毒素的研究进展

If the scorpion venom of BmK 0.18mg/kg are administered by iv , thier blood pressure appeared double phase variety which was raised after depression .

iv0.18mg/kg蝎毒血压呈先降后升双相变化。

Effect of BmK AS-1 , polypeptide purified from Chinese Buthus martensi Karsch ( BmK ) toxin , on rat cutaneous nociception

东亚钳蝎毒素多肽BmKAS-1对大鼠皮肤痛觉的影响

BmK IT is an insect excitatory neurotoxin cloned in Buthus martensii Karsch which is a sort of scorpion mainly distributed in our country .

BmKIT是从广泛分布于我国的东亚钳蝎中克隆出来的兴奋型昆虫毒素。

Isolation and purification of BmK AS-like peptides from the venom of scorpion Buthus martensi Karsch and effect of BmK AS'on [ Ca ~( 2 + ) ] _i in cultured rat skeletal-muscle cell

东亚钳蝎毒素BmKAS类多肽的分离纯化及对大鼠骨骼肌细胞内[Ca～（2+）]i的影响

Results ① The non-cytotoxic dose of BMK (μ g / ml ) significantly decreased the IC_ ( 50 ) value of ADM and increased the intracellular ADM accumulation in MCF-7 / ADM cells ( P < 0.01 , P < 0.05 ) .

结果①非细胞毒性剂量（3.0μg/ml）蝎毒能显著降低MCF-7/ADM的IC50（P<0.01），增加MCF-7/ADM细胞内ADM的药物积累（P<0.01）。

Methods Liver cancer Bel ? 7407 cells cultured in vitro were exposed to different concentrations of BMK over 72 hours and their enzymatic activity was measured using polymerase chain reaction-telomere repeated amplification ( PCR ? TRAP ) . Meanwhile cell proliferation suppression was measured using MTT .

方法：不同浓度的BMK处理体外培养的人肝癌Bel7404细胞72h，聚合酶链反应端粒重复扩增（PCRTRAP）法测定端粒酶活性，四甲基偶氮唑盐比色（MTT）法测定细胞增殖抑制。

BMK ( 3 μ g / ml ) combined with ADM increased the apoptosis inducing effect of ADM to MCF-7 / ADM cells , which of apoptosis percentage was increased from ( 8.9 ± 0.01 )﹪ to ( 12.6 ± 0.21 )﹪( P < 0.01 ) .

蝎毒（3.0μg/ml）联合ADM后增强了对耐药细胞的凋亡诱导作用，凋亡率由8.9±0.01%上升为12.6±0.21%（P<0.01）。

The changes in specific activities of the adenylate cyclase ( AC ) and cAMP phosphodiesterase ( PDE ) in tumor were observed after intraperitoneal injection of Harringtonine or subcutaneous injection of Buthus martensi Karsch ( BMK ) crude extract and LRH-A.

我们观察了腹腔注射三尖杉酯碱对大鼠移植性肝癌（BERH-2）和皮下注射全蝎提取物与LRH.A对乳腺癌组织腺苷酸环化酶（AC）和环腺苷酸磷酸二酯酶（PDE）比活力的影响。