apoa

Molecular pathological study of intracranial aneurysm : APOA gene poly morphism

颅内动脉瘤分子病理学研究：APOA基因多态性

The levels of HDL , ApoA are independent protective factors of coronary lesion .

高密度脂蛋白、载脂蛋白A为冠状动脉病变独立保护因素。

The effect of HDL 3 was stronger than apoA ⅰ in a time dependent manner .

HDL3的作用明显大于apoA，且呈时间依赖性。

Therefore , apoA 1 released by the injured nerve may originate from the bloodstream .

因此，由损伤神经释放的apoA1很可能是从血流而来的。

The Physiological Function of Plasma apoA - ⅰ── The Anti-viral Effects of apoA - ⅰ and Its Fragments

血浆载脂蛋白A－Ⅰ生理功能的研究&A－Ⅰ及其裂解片段对单纯疱疹病毒感染细胞的作用

Objective To obtain high yield of recombinant human apolipoprotein A - ⅰ ( apoA - ⅰ) with normal structural and functional properties by a prokaryotic expression system .

目的为获得高产量并具有正常结构和生物学活性的原核表达人载脂蛋白A-Ⅰ（apoA-Ⅰ）。

Because of secret expression with high level the ApoA ⅰ which accounted for 70 % in the soluble protein was very easy to be purified .

本研究的ApoAⅠ的表达为分泌表达，蛋白纯度高，占可溶性蛋白的70%以上，分离纯化简便，蔡钦生同学经低温丙酮分级沉淀一次性获得纯度高于90%的ApoAⅠ。

The increase in apoA 1 content in the injured nerve of alcoholic fed rats is due to an enhanced permeability of the nerve blood barrier .

而乙醇喂养的老鼠损伤神经中apoA1含量的增加，是由于增强了神经&血液屏障的通透性。

The Role of Oligonucleotides - 93 ~ - 63 bp of ApoA - ⅰ Promoter and - 75 Mutant on Gene Transcription Regulation

apoAⅠ启动子-93bp～-63bp片段及-75bp位点突变对基因转录调控作用的研究

The success of high expression of ApoA ⅰ shows the superiority of P.pastoris and will meet its large research , production and Application for the target-drug of liver .

本论文重组ApoAⅠ成功的分泌表达且表达水平明显高于其它表达系统，再次显示了P.pastoris表达系统的优势，也为ApoAⅠ作为肝脏靶向药物的研究、制备和应用奠定了基础。

Objective To study the relationship between a pentanucleotide repeats ( PNR ) polymorphism of APOA and the genesis of intracranial aneurysm .

目的本研究拟从基因水平探讨APOA基因多态性与颅内动脉瘤发病的相关性。

UAER in group A was higher than that in group B , age , the duration of diabetes and ApoA in group A were lower than that in group B ( P < 0.05 ) .

B组与A组相比，UAER高于A组（P<0.05），年龄、病程，ApoA低于A组（P<0.05）。

Conclusion The hepatic lipase gene promoter - 514C / T polymorphism is related with the levels of HDL - C and apoA I in type 2 diabetes and that with coronary heart disease .

结论在2型糖尿病及其冠心病合并症中，HL基因启动子-514C/T基因多态性对血脂水平有一定影响。

These results indicate that the cysteine mutations at the different sites have not significant effect on the α helical content of apoA - ⅰ, but have different influence on its secondary structural stability and its ability to bind to lipids .

以上结果提示，不同位点发生的半胱氨酸突变对apoA-Ⅰ单体蛋白的α螺旋含量无明显影响，但对蛋白的二级结构稳定性和脂质结合能力影响不尽相同。

The cytotoxic activity of LL-37 is inhibited by apolipoprotein A - ⅰ( apoA - ⅰ) in the plasma , thereby it can function as a scavenger of LL-37 and prevent host cell damage .

血浆中的apoAⅠ可结合LL37并抑制其细胞毒性作用，从而使机体免受LL37的损伤。

When testing the precision of the samples of high and low serum , the within-run ApoA CV were 1.011 % and 2.993 % respectively , and its daytime-run CV were 1.010 % and 2.503 % respectively .

对高、低血清标本进行精密度测定，批内ApoAICV值分别为1.011%和2.993%，日间CV值分别为1.010%和2.503%。

Aim To construct recombinant adeno-associated viruses ( rAAV ) vectors carrying human apolipoprotein A ⅰ ( apoA ⅰ) and apo A ⅰ Milano cDNA , and explore a new strategy to prevent and treat the atherosclerotic diseases .

目的以重组2型腺相关病毒为载体介导人载脂蛋白AⅠ及载脂蛋白AⅠMilano在小鼠肌源性细胞C2C12中的表达，探索一种崭新的预防、治疗动脉粥样硬化性疾病的途径。

The results showed that , ( 1 ) serum levels of glucose , TG and apoA , were increased significantly immediately after aerobatics in comparison with those before aerobatics , 6 hand 24 h after aerobatics ( P < 0.05 ) .

结果显示：①飞行后即刻血糖、TG及apoA1明显升高，与飞行前及飞行后6h、24h比较，均有显著性差异（P＜0.05）；

In this work , a simple and sensitive method has been developed to determine picoliter apoA ⅰ using the PMMA microfluidic chip coupled with electrochemical detection system . The results show that this kind of method is practicable and has the potential application in clinical analysis and diagnosis .

基于微流控芯片三电极检测系统，我们构建了一种简单而又快速的检测方法，结果显示这种方法具有很好的实用性，在临床分析和诊断中具有潜在的应用价值。

Results With the decrease of serum HDL-C levels , the apoA - ⅰ contents of pre β 1-HDL and HDL 3b increased and were significantly higher ( P < 0 01 ; P < 0 05 ) in the low HDL-C group than in the high HDL-C group .

结果随血清HDL-C水平逐渐降低，preβ1-HDL、HDL3b含量呈增加趋势，与高HDL-C组比较，低HDL-C组preβ1-HDL（P<0.01）、HDL3b（P<0.05）含量显著增加；