apap

Our results demonstrated that HIF-1 α expression increased during APAP or D-GalN / LPS induced acute liver failure .

本实验结果显示对乙酰氨基酚、D-氨基半乳糖联合内毒素诱导的急性肝衰竭时HIF-1α表达增加。

The reason of impure spots formation in the APAP medicine has been found after repeated experiments .

通过反复实验，找出了扑热息痛产生杂斑的原因；

Acute hepatocytes injury caused by APAP and effects of verapamil pretreatment

急性醋氨酚中毒致肝损伤及维拉帕米预处理的作用

The most common drug that can induce liver injury is acetaminophen ( APAP ) .

据报道有1000多种药物能引起肝损伤，其中最常见的药物是对乙酰氨基酚（Acetaminophen，APAP）。

Acetaminophen ( APAP ) is widely used as analgesic and antipyretic drugs .

对乙酰氨基酚（APAP）是临床上广泛使用于退热镇痛的药物。

Objective To evaluate the mechanisms of hepatocytes injury caused by APAP poisoning and to investigate the role of verapamil pretreatment .

目的通过观察[Ca2+]i、MDA、SOD、LDH在急性醋氨酚（APAP）致肝损伤中的变化，探讨APAP致肝损伤机制，并且观察维拉帕米预处理是否可以预防。

It might need further study whether single-night APAP treatment is most appropriate for confirming the effectiveness of using CPAP pressure .

仅一夜APAP治疗能否确定最适CPAP治疗压力仍需进一步研究。

APAP hepatotoxicity is the leading cause of DILI .

对APAP的肝毒性是导致药物性肝损伤的主要原因。

However APAP had remarkable ( P < 0.05 ) hypoglycemic effect on diabetic rats induced by alloxan , at a dose level of 100mg / ( kg · d ) .

对四氧嘧啶致糖尿病小鼠有明显的降血糖作用，100mg／kg的剂量即能显著降低糖尿病小鼠的血糖水平（P＜0.05）。

In this study , acetaminophen ( APAP ) and D-galactosamine / lipopolysaccharide ( D-GalN / LPS ) were used to induce acute liver failure in mice , and the protective effect and molecular mechanism of AA and SDS on these animal models were discussed .

本研究采用对乙酰氨基酚、D-氨基半乳糖联合内毒素诱导的急性肝衰竭作为动物研究模型，探讨刺五加酸、红景天苷对急性肝衰竭的保护作用以及干预机制。