SIPI

OBJECTIVE To investigate the metabolic profile of SIPI in rats .

目的考察SIPI在大鼠体内的代谢转化。

A retrospect of research and development of new pharmaceutical preparations since the establishment of SIPI in 1957 is presented .

回顾了上海医药工业研究院自1957年建院以来对新型药物制剂的研究开发。

Main achievements of SIPI in pharmaceutical equipments

我院制药装备研究开发的主要成果

RESULTS : Three compounds were isolated from Aspergillus versicolor sp. SIPI 17 and their structures were elucidated .

结果：从杂色曲霉菌株中分离出3个结构类似的醌类化合物，确定其化学结构和总结其生物活性。

In the course of screening metabolites of immunosuppressants from microorganisms using yeast screening model , a positive strain SIPI 96 886 was obtained .

利用酵母筛选系统筛选免疫抑制剂得到了阳性菌株SIPI96886。

A study on Micromonospora SIPI 436 and its metabolites fortimicin a

小单孢菌SIPI436及其代谢产物福提霉素A

CONLUSION : Compound SIPI 1 3 and 4 were first reported with new structures , Their lowering cholesterol biosynthesis activities were first found so far .

结论：化合物SIPI－1－3和4为首次报道的新结构化合物，抑制胆固醇生物合成活性也为新发现。

This article reviews the development of antihypertensive drugs and introduces the research survey of antihypertensive drugs in Shanghai Institute of Pharmaceutical Industry ( SIPI ) for 40 years .

本文综述了抗高血压药物的发展和介绍了上海医药工业研究院（SIPI）40年来抗高血压药物的研究概况。

Using ethyl acetate extraction , silica gel column chromatograph and HPLC etc. , a compound SIPI 807 1 was isolated from its fermentation broth .

应用乙酸乙酯提取、硅胶柱层析和高效液相色谱等方法，从上清液中分离出活性物质SIPI-807-1；

The properties of β fructofuranosidase ( 1 ) from a fructooligosaccharides producing strain , Aspergillus niger SIPI 602 , were investigated .

研究了低聚果糖产生菌黑曲霉（Aspergillusniger）SIPI-602的β-呋喃果糖苷酶（1）的性质。

METHODS Liquid chromatography-tandem mass spectrometry ( LC-MSn ) was used for the separation and analysis of SIPI and its metabolites in rats urine , feces and bile after an intravenous dose of SIPI .

方法采用液相色谱-质谱（LC-MSn）联用技术，检测在单剂量静脉注射给予SIPI后大鼠尿，粪及胆汁中的SIPI及代谢物。