SELEX

Preliminary establishment of a novel cell SELEX based on capillary electrophoresis technology

基于毛细管电泳的细胞SELEX方法的初步建立

Applications of SELEX in the Diagnosis and Treatment of Viral Infection

SELEX技术在病毒感染诊断和治疗中的应用

The Establishment of the Selex Method with a Random RNA Library and Its Application

随机RNA文库技术的建立及其应用

Comparison of two enrichment methods in SELEX

SELEX实验中两种富集方法的比较

In Vitro Selection of Aptamers to Gastric Cancer Cells SGC-7901 by SELEX

SELEX法体外筛选胃癌细胞SGC-7901适配子方法的建立

SELEX Screening and Characterization of Small RNA Molecules That Specifically Bind the Reactive Blue Dye

特异亲和活性蓝染料的小分子RNA的SELEX筛选

What percentage of these can be screened in a SELEX experiment ?

有多少百分比可以用SELEX实验筛选出来？

Screening out specific aptamers to unknown target molecules is the outstanding characteristic of SELEX .

SELEX技术的一个突出特点是可以盲筛获得未知靶分子的特异性适配子。

SELEX ( systematic evolution of ligands by exponential enrichment ) is a new combinatorial chemistry technology .

指数富集配基的系统进化（SELEX）技术是一种新的组合化学技术。

Effect of different isolations for nucleic acid and protein complex on affinity of enriched library in SELEX experiment

SELEX实验中核酸-蛋白复合物分离方法对富集库亲和力的影响

Construction of Targeted Photosensitizer by SELEX Technology

利用SELEX技术构建靶向光敏药物

SELEX Screening Aptamers for Ricin by Two Enrichment Methods

两种富集方法相结合对蓖麻毒素进行SELEX筛选研究

A Procedure for SELEX Screening Aptamers From ssDNA Random Library

随机单链DNA文库SELEX筛选寡核苷酸适配子方法的建立

In Vitro Selection of Aptamers to Staphylococcal Enterotoxin B ( SEB ) by SELEX and Application

利用SELEX技术筛选金黄色葡萄球菌肠毒素B（SEB）适体的研究及应用

Here the current designs and application of modified nucleotides for in SELEX process are reviewed , and expected to further the utility of this method in both practical and theoretical terms .

回顾了SELEX的研究和应用，期待着这一方法能够在理论和实践上得到进一步的发展。

Objective To compare the effect of different partition of nucleic acid protein complex on the affinity of enriched library in systematic evolution of ligands by exponential enrichment ( SELEX ) .

目的比较SELEX实验中，核酸蛋白复合物分离技术的差异对筛选富集库亲和力的影响。

As a result of the development of SELEX technology , we obtained the appropriate gametes which have high affinity and specificity with small molecular , peptide , protein , even the entire cell .

由于SELEX技术的发展，得到了能和小分子、多肽、蛋白质甚至整个细胞均有高亲和力、特异性的适配子。

SELEX is a kind of combinatorial chemistry technology , by which nuclear acid aptamers with high specificity and affinity to targets could be screened out from a random oligonucleotide library .

SELEX技术是一种组合化学新技术，应用该技术可从人工合成的随机单链寡核苷酸文库中筛选出能与靶分子高特异性、高亲和力的核酸适配子。

They are single-stranded oligonucleotides , which are generated from an in vitro method known as SELEX ( systematic evolution of ligands by exponential enrichment ) and can bind to variety of targets .

它是一种可以识别多种靶标的短的单链核苷酸序列，通过指数富集的配体系统进化（SELEX）技术体外筛选得到。

SELEX ( systematic evolution of ligands by exponential enrichment ) is a method developed to search among large random-sequence oligonucleotide library for aptamer with high-affinity and high-specific binding to defined molecular target .

核酸配基扩增技术（SELEX）可从极大容量的随机寡核苷酸文库中筛选得到与靶分子高特异性和高亲和力结合的核酸配基。

Objective : To establish a SELEX screening method and obtain the aptamers that specially bind to SGC-7901 gastric cancer cells , the binding activity of the aptamers were detected to validate their affinity and specificity against gastric cancer cells .

目的：建立SELEX技术体外筛选胃癌细胞SGC-7901适配子的方法，以获得能与SGC-7901细胞特异性结合的适配子。

Results and Conclnsions : The RNA library was subjected to 9 successive rounds of selection with SELEX method , resulting in an increase in the percentage of the gp16_binding RNA from 14.4 % for the first round pool to 37.8 % for the ninth_round pool .

结果与结论：经9轮筛选获得与gp16特异结合的RNA适体，结合百分数从未经筛选的14.4%增加到第9轮的37.8%。