AIF

AIF is One of the Critical Mitochondrial Proteins to Mediate Nuclear Apoptosis

凋亡诱导因子是线粒体内介导核凋亡的最主要蛋白质之一

Expression of AIF in the hippocampus of pentylenetetrazole-kindled rats

凋亡诱导因子在戊四氮致痫大鼠海马组织中的表达

Preliminary studies on construction , expression and function of recombinant AIF plasmid

AIF重组质粒的构建、表达和功能的研究

Mutation and Expression Analysis of AIF in Renal Cancer Tissue

肾癌组织中AIF的突变与表达分析

Apoptosis Inducing Factor , Mouse , Control Peptide ( AIF )

凋亡诱导因子，小鼠，对照肽（AIF）

Antitumor Activity of Targeted Recombinant Human AIF on HER-2 Positive Carcinoma

靶向性重组人AIF分子对HER-2阳性肿瘤细胞的杀伤作用研究

Conclusion : AIF may be a diagnostical index for breast carcinoma .

结论：酸性同功铁蛋白的检测可以作为乳腺癌早期诊断指标之一。

Thus , expression of recombinant human AIF could induce the transfected HeLa cells apoptosis .

因此，重组AIF融合基因的表达能够诱导HeLa细胞发生凋亡。

Recent researches showed the high expression of AIF in renal tissue may correlates with the occurs of renal cancer .

近年研究提示正常肾组织中高表达的AIF可能与肾癌的发生发展相关。

Effects of Emodin on Expressions of AIF and EndoG in Hepatoma Cell Lines

大黄素对肝癌细胞AIF和EndoG蛋白表达的影响

AIF youre never hurt AIF youre never down .

仿佛从没有沮丧过。

Expressions of AIF , Bax and Bcl-2 in the intestinal injury induced by neutron and γ irradiation

AIF、Bax和Bcl-2在中子及γ射线照射致肠道损伤中的表达

Apoptosis Inducing Factor ( AIF ), Internal antigen sequence , Rabbit anti-Human , Mouse , Rat ; WB .

凋亡诱导因子（AIF），内抗原序列，兔抗人，小鼠，大鼠；WB。

This study provides a new basis for the further exploration of the effect of Abl tyrosine kinase family on apoptosis inducing factor AIF .

本研究为进一步探讨Abl家族酪氨酸激酶对细胞内凋亡诱导因子AIF的影响提供了新的依据。

Ischemia / reperfusion time , PT and the opening hole damage , Cyt C and AIF were released into the cytoplasm .

缺血/再灌注（MI/R）时，PT孔受损而开放，CYTC及AIF被释放入胞浆。

This study was to clone and express recombinant human Δ 1-120 AIF and validate its biological activities of binding DNA and inducing nuclear apoptosis .

本研究的目的在于克隆、表达重组的人截短型AIF，并对其诱导肿瘤细胞核凋亡的生物学活性进行鉴定。

RESULTS : The 1.5 kb AIF gene was successfully isolated , and cloned into pET32a ( + ) vector .

结果：获得了去掉线粒体定位信号的AIF基因，并克隆到pET32a（+）载体中，经酶切与测序鉴定完全正确。

MPT blocker could completely block the release of AIF or EndoG , and partly blocked the macrophages apoptosis .

MPT阻断剂可以部分性阻断细胞凋亡，完全阻断AIF或EndoG的释放。

In studied typical acidified waters . the main species of the four elements are DOC . NO Se ( IV ) and AIF .

被研究的典型酸化水体中4种元素的最主要的形态分别为DOC、Se（IV）和。

The biological activity of renatured AIF protein was detected by electrophoretic mobility shift assay ( EMSA ) and Hoechst staining .

采用凝胶滞后实验（EMSA）与Hoechst33258染色检测AIF蛋白的生物学活性。

Results of immunofluorescent staining confirmed that AIF and / or EndoG translocation from mitochondria to the nucleus , thereby inducing cell apoptosis .

但是免疫荧光染色证实钩体感染后AIF或EndoG从线粒体转位到细胞核，从而诱导细胞凋亡的发生。

Concluction : the expression of AIF is closely related with the genesis of cervical cancer and it is an effective marker in diagnosis of cervical cancer .

结论AIF蛋白表达水平与宫颈癌的发生密切相关，是评估宫颈癌的可靠指标。

125I-monoclonal antibodies against H subunit of AIF ( AIF-H ) was prepared by the chloramine-T method .

125Ⅰ－抗AIF－H亚基单克隆抗体用氯胺－T法制备；

Objective : To investigate the value of combined estimation of acidic isoferritin ( AIF ) and alpha-fetoprotein ( AFP ) in the diagnosis of primary liver cancer ( PLC ) .

目的：探讨酸性同工铁蛋白（AIF）与甲胎蛋白（AFP）联合检测对原发性肝癌诊断的价值。

The N terminal of AIF protein contains mitochondrial localization sequence MLS , while C terminal contains oxidoreductase domain which is namely bonding domain of FAD and NAD that contains two nuclear localization sequences NLS .

AIF蛋白N端含有线粒体定位序列MLS，C端含有氧化还原酶结构域即FAD和NAD结合区包括两个核定位序列NLS。

Acidic isoferritin ( AIF ) was isolated by means of homogenization , heating , acidification , ammonium sulfate fractionation , ultracentrifugation , Sepharose CL-4B column chromatography and preparative electrofocusing from human cardiac muscles .

人心肌匀浆经热变性、酸化、硫酸铵盐析、超离心、SepharoseCL－4B柱层析和制备等电聚焦分离，得到酸性铁蛋白。

Under normal physiological conditions , AIF exists between inside and outside mitochondrial membrane , and carries out oxidoreductase function via its FAD binding of N terminal and redox activity , and also plays an important role in maintaining the normal existence of mitochondria .

在正常生理状态下，AIF位于线粒体内外膜之间，可以籍其N末端FAD结合区和其氧化还原活性来行使氧化还原酶的功能，并具有维持线粒体的正常生存的作用。

FSN could promote the apoptosis via caspase-dependent , AIF pathway and curb the excessive proliferation of synovium by regulating ROS generation in vivo to affect synovial mitochondrial function , the Th cell differentiation to play its therapeutic effect . 3 .

FSN通过调节体内ROS的生成影响滑膜线粒体功能及Th细胞的分化，促进经caspase依赖性途径、AIF途径的细胞凋亡，抑制滑膜的过度增殖，从而发挥其治疗作用。

In mitochondrial pathway , IL-ip decreased the expression of the anti-apoptotic proteins , Bcl-2 and Bcl-xL ; increased the expression of the apoptosis inducer , Bax , and promoted the release of apoptosis inducing factor ( AIF ) .

在线粒体途径中，IL-1β可使Bcl-2、Bcl-xL蛋白表达下降，而使Bax的表达水平升高，并可促进凋亡诱导因子（AIF）的释放。

Yan 's leadership , AIF 's investment in Shanda Interactive Entertainment ( SNDA ) has been named " the Investment of the Year " in2003 and SAIF was voted as " VC Firm of the Year " .

SAIF在盛大娱乐互动有限公司的投资于2003被评选为“年度最佳投资案例”，并于2004年被评选为“年度最佳退出案例”。