ADME
- 网络吸收、分布、代谢与排泄;体内过程;药物代谢;代谢和排泄;排泄
![ADME](../cache/638585.jpg)
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In Vitro Models Used to Screen for Human ADME Drug Properties
药物体外ADME筛选模型
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Studies on the ADME / Tox Characteristics of Xiao Chai Hu Tang in Caco-2 Cell Model
小柴胡汤基于Caco-2细胞模型的ADME/Tox特征研究
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Traditionally , ADME / T did not draw enough attention , resulting in high failure rate of drug candidates in clinical trials .
传统的药物设计中对ADME/T性质的重视不够,导致候选药物在临床试验阶段失败率极高。
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Theoretically predicting the ADME / T properties of drug candidates can improve the success rate of drug development and reduce spending and time wasted .
因此,在药物研发初期就考虑ADME/T性质将会有助于提高候选药物的成功率,从而减少药物开发的时间和金钱上的浪费。
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Structural descriptors , descriptors related to ADME and the ligand-receptor binding free energy were calculated to characterize compounds .
在此基础上计算了ADME性质相关的描述符、基于配体-受体相互作用的描述符等对小分子结构进行表征。
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High throughput techniques and computer models are widely used in the absorption , distribution , metabolism , excretion , and toxicity ( ADME / Tox ) studies of drugs .
无机物的吸收、分配、代谢和排除以及毒性(ADME/Tox)研究在药物和毒物研究中非常重要。
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With the increasing exploitation of new medicaments , absorption , distribution , metabolism , excretion and toxicity ( ADME / T ) of drugs in vivo have been attached importance to .
随着新药的不断开发,药物在生物体内的吸收、分布、代谢、排泄和毒性(ADME/T)等性质已经引起了人们的高度重视。