黏膜白斑

喉黏膜白斑和喉鳞状细胞癌中survivin表达的意义

Role of survivin expression in laryngeal leukoplakia and laryngeal squamous cell carcinoma

PTEN、p53在口腔黏膜白斑和口腔鳞癌组织中的表达及意义

Expression and Significance of PTEN 、 p53 in Oral Leukoplakia and Oral Squamous Cell Cancer

目的：研究口腔鳞癌（OSCC）及口腔黏膜白斑（OLK）组织中HPV感染与Survivin的表达，探讨上皮组织肿瘤的形成机制。

Objective : To investigate survivin expression and HPV infection in oral leukoplakia ( OLK ) and oral squamous cell carcinoma ( OSCC ) and to further explore the mechanism of HPV 's carcinogenesis in oral carcinoma .

方法应用免疫组化对46例喉鳞状细胞癌、24例癌旁组织、20例喉乳头状瘤、28例喉黏膜白斑和16例正常喉黏膜中Survivin的表达情况进行检测。

Methods The expression of Survivin protein wsa detected with immunohistochemical method in 46 specimens from laryngeal squamous cell carcinoma , 24 from adjacent nontumorous laryngeal epithelium , 16 form normal laryngeal epithelium , 20 from adult laryngeal papilloma specimens , and 28 form laryngeal leukoplakia .

机会性感染发生率为85.5%，感染类型由高至低依次为：肺炎、口腔毛状黏膜白斑（OHL）、口腔真菌感染、各种感染性腹泻、各种结核病、败血症、疱疹病毒感染。

Ratio of occurred opportunistic infection was 85.5 % . The types of opportunistic infection in sequence from high to low incidence are : pneumonia , oral hairy leukoplakia ( OHL ), oral candidiasis , infectious diarrhea , tuberculosis , anemia , herpesvirus infection .

端粒酶基因在口腔黏膜白斑与口腔癌中的表达

Expression of telomerase genes in oral leukoplakia and oral carcinoma

中老年人口腔黏膜白斑的回顾性分析

The retrospective analysis of oral leukoplakia in old people

56例老年口腔黏膜白斑的回顾分析

Retrospective analysis on oral leukoplakia in 56 aged patients

前言：目的：探讨老年口腔黏膜白斑患者的临床特点。

Objectives : To explore the clinical feature of oral leukoplakia in elderly patients .

口腔黏膜白斑、背部皮损组织及粪便真菌培养均为白念珠菌生长。

The fungus culture with mucosa blaze in the mouth , lesion on the back and night soil all showed Candida albicans .

结论白斑是癌前病变，女性及40岁以上口腔黏膜白斑患者要积极治疗及加强随访。

Conclusion Oral leukoplakia was the precancerous lesion . The female patients and the patients over 40 years should take an active treatment and were follow-up visited frequently .

结果8例声带息肉患者除1例失随访外均未复发，治愈率100%，喉乳头状瘤患者1例于半年后复发，黏膜白斑病患者失随访。

Results 8 patients suffer from polyp of vocal cord never recurrent except one out of visit , the cure rate is100 % ; one from laryngeal papilloma recurrents half a year after surgery ; one from leukoplakia is out of visit .

MMP鄄9在口腔正常黏膜、白斑、白斑癌变和舌鳞癌组织中阳性率分别为50%、100%、100%和83%。

The positive rates of MMP-9 of oral normal mucosa , leukoplakia , leukoplakia cancer , and tongue squamous cell carcinoma were 50 % , 100 % , 100 % , and 83 % , respectively .

结果：Cox-2及VEGF的表达从正常口腔黏膜到口腔白斑以至口腔鳞癌演变过程中不断增高，Cox-2在高分化鳞癌中表达量最高（0.167±0.004），随癌的分化程度降低而减少；

RESULTS : The expressions of Cox-2 and VEGF increased significantly as the progression of oral mucosa from normal to oral leukoplakia and oral SCC . The expression of Cox-2 reached peak in well differentiated SCC ( 0.167 ± 0.004 ), and its expression decreased sharply as differentiation became poor .