神经原纤维

它们包括：核内包含物的出现，神经原纤维缠结，胞质内脂褐素体的堆积等。

They included the appearance of inclusions in nucleus , neurofibril nodule in cytoplasm of neurons and accumulation of lipofuscin in the cytoplasm .

Tau蛋白高度磷酸化形成的神经原纤维缠结主要见于神经系统变性疾病。

Neurofibril tangle formed by high phosphorylation of Tau protein is mainly seen in degenerative diseases of nervous system .

去磷酸化对Alzheimer神经原纤维缠结结构和功能的影响

Effect of Dephosphorylation on the Structure and Function of Alzheimer Neurofibrillary Tangles

tau蛋白在老年性痴呆症神经原纤维退行性变中的作用

Role of tau Protein in Neurofibrillary Degeneration of Alzheimer Disease

其中，神经原纤维缠结的主要成分是异常磷酸化的tau蛋白。

The main component of neurofibrillary tangles is the abnormal phosphorylated tau protein .

CAA往往同时伴有老年斑和神经原纤维缠结。

The CAA was often accompanied with the senile plaques and neurofibrillary tangles .

阿尔茨海默病（AD）是引起痴呆的最常见类型之一，其主要病理改变包括由β-淀粉样蛋白构成的老年斑、神经原纤维缠结。

Alzheimer 's disease ( AD ) is the most common form of dementia , the pathological features of AD include neuritic plaques composed of beta-amyloid protein , neurofibrillary tangles .

主要临床表现为认知障碍、记忆功能进行性减退等，主要的病理改变包括在细胞外积聚的老年斑、细胞内的神经原纤维缠结（Neuronsfibertangles，NFT）以及海马神经元丢失。

The major clinical manifestations are cognitive impairment and memory function progressive decrease . The main pathological changes including the accumulation of senile plaque outside the cell , the ( Neurons fiber tangles , NFT ) inside the cell and loss of neurons in the hippocampus .

结缔组织中除有成纤维细胞和颗粒细胞外还充满胶原原纤维和肌原纤维，无髓神经原纤维也较多。

All cells have secretory and absorptive functions besides4ibblasts and granular cells in connective tissue , there are myofibril , collagenous fibril and unmyelinated fibers .

目的：阿尔茨海默病的两大病理特征是老年斑与神经原纤维缠结，这两种病变可导致渐进的神经元变性并与神经元死亡有关。

OBJECTIVE : Alzheimer 's disease is characterized by the formation of two main protein aggregates : senile plaques and neurofibrillary tangles , which are involved in the process leading to progressive neuronal degeneration and death .

目的探讨谷氨酸兴奋毒性对大鼠视网膜神经胶质原纤维酸性蛋白（Glialfibrillaryacidprotein，GFAP）的影响及牛磺酸干预对此的作用。

Objective To study the effects of glutamate excitotoxicity and taurine intervention on retinal expression of glial fibrillary acid protein ( GFAP ) in rats .

应用免疫荧光与免疫酶法双重染色，计数BrdU阳性细胞表达神经元特异性烯醇酶、神经胶质原纤维酸性蛋白的比例。

Immunofluorescence and immunoenzymic method double staining were used to measure the ratio of neuron specific enolase and glial fibrillary acidic protein expressed by BrdU positive cells .

目的研究经皮电针对背根节慢性压迫模型（CCD）大鼠相应腰髓节段神经胶质原纤维酸性蛋白（GFAP）和血清素（5-HT）的影响和与疼痛的关系。

Objective To research the effect of transcutaneous electric nerve stimulation ( TENS ) on the GFAP and 5-HT positive staining cells in corresponding lumbar spinal cord in rat model with chronic compression of dorsal root ganglion , and its correlation with pain .

骨髓间充质干细胞双重免疫组化染色结果：缺血区BrdU阳性细胞表达神经元特异性烯醇酶和神经胶质原纤维酸性蛋白的比例分别是（4.53±1.80）%，（3.66±0.87）%。

Results of MSCs double staining : The percentage of BrdU-positive cells expressing neuron specific enolase and glial fibrillary acidic protein was ( 4.53 ± 1.80 ) % and ( 3.66 ± 0.87 ) % , respectively in ischemic zone .

AD的特征性病理学改变为大脑皮质神经细胞内神经原纤维缠结、细胞外大量老年斑形成和大脑皮质细胞减少。

The main histopathological hallmarks of AD are extracellular amyloid plaques and intracellular neurofibrillary tangles ( NFTs ) in brain cortex , and decrease of brain cortex cells .

通过神经丝染色和神经胶质原纤维酸性蛋白染色，观察神经纤维穿越胶质疤痕和移植物的生长情况，计数神经丝染色阳性面积。

With the staining of the neurofilament and the glial fibrillary acidic protein , the neural fiber growing across the glial scar and the transplantation was analysed , and its positive area was quantified .

结论轴突漏可能是AD关键性的神经病理改变，不但可能导致斑块的产生和神经原纤维缠结的形成，而且可能是AD认知障碍的主要原因。

Conclusion Axonal leakage might be a key neuropathological change , and probably lead to the formation of plaques and neurofibrillary tangles , and may also play a causative role in the cognitive deficit in AD.

其突出病理特征是脑神经细胞外β-淀粉样蛋白（Aβ）沉积与淀粉样斑块形成，tau蛋白过度磷酸化与神经原纤维缠结。

Its special pathological feature is A β deposition outside the nervous cells and amyloid plaque formation , tau protein over phosphorated and neural fibers twist .

结果AD患者脑出现重要的神经病理改变轴突漏（axonalleakage）。轴突漏常伴随肿胀的轴突和轴突膨体，且与传统的神经病理改变斑块和神经原纤维缠结有明显的相关性。

Results A new neuropathological change - " axonal leakage " in the brains of AD patients was identified , which was accompanied by swellings of varicosities and axons , and was related to the degree of senile plaques and neurofibrillary tangles .

多种神经系统退行性疾病中都出现了细胞骨架的异常。其中许多疾病出现了tau蛋白相关的病理改变，如AD中的神经原纤维缠结，提示慢性应激与tau蛋白异常之间存在相关性。

Cytoskeletal abnormality has been observed in a variety of neurodegenerative diseases , among many of these diseases , tau protein related pathological changes are often observed , such as the neurofibrillary tangles in Alzheimer disease , suggesting the correlation between chronic stress and tau protein abnormality .