梭曼

氨基甲酸酯类药物和梭曼对N乙酰胆碱受体代谢的影响

The Effects of Carbamates and Soman on the Metabolism of Nicotinic Acetylcholine Receptors in Cultured Skeletal Muscle Cells

VE，VA对梭曼致大鼠过氧化损伤的保护作用

Protective effects of V_E / V_A against free radical injury induced by soman in rats

维生素A和维生素E对梭曼染毒大鼠自由基损伤的预防作用

Prophylactic effect of vitamin A and vitamin E against free radical injury produced by soman in rats

测定梭曼四种立体异构体的NMR研究

NMR study on Determination of the four stereoisomers of soman

高原缺氧条件下梭曼中毒大鼠心肌GiαmRNA表达的变化

The Expression of Myocardium Gi α mRNA after Soman Intoxication Combined High Altitude Hypoxia in Rat

结果梭曼中毒后，T-AOC水平、VE含量下降，NOS活性提高.中毒前后大鼠肝脏中VE质量分数从（0.83±0.02）mg·g-1下降至（0.45±0.06）mg·g-1；

RESULTS The VE contents , T-AOC level decreased and NOS activities increased after soman intoxication .

由于CNS病变与惊厥有密切关系，因此梭曼中毒后必须应用抗惊剂。

As CNS lesions were closely correlated with convulsions , anticonvulsants must be used after soman poisoning .

梭曼中毒诱导PC（12）细胞JAKs表达

JAKs expressions in cell line PC_ ( 12 ) induced by soman intoxication

梭曼急性中毒诱发大鼠脑干儿茶酚胺神经元表达c-fos

Expression of protooncogene c fos in catecholamine neurons in the brain stem after acute soman intoxication in rats

用体外放射性配体结合实验方法检测了梭曼对牛小脑γ-氨基丁酸（GABA）受体和GABA摄取的影响。

Effect of soman on ~ 3H-GABA binding to GABA receptor and GABA up-take of bovine cerebellum was studied in vitro .

方法：测定大鼠血液中梭曼残留浓度及组织中羧酸酯酶（CaE）活性。

Methods : Residual levels of soman in blood were measured using electric eel acetylcholinesterase based microassay and carboxylesterase activity in rat tissues was measured .

沙林及梭曼的水解产物在G类毒剂水解酶催化下有外加胆碱酯酶存在时，可以生成相应的毒剂，表现为对外加胆碱酯酶活性的深度抑制。

Sarin and soman are catalytically synthesized by the G-type organophosphate hydrolase in vitro from their corresponding hydrolytic products in the presence of additional cholinesterase showing as the deep inhibition of the later enzyme .

目的研究梭曼引起神经肌接头突触后膜持续性去极化（SD）的产生机制。

Objective To study the mechanism underlying the sustained depolarization ( SD ) of neuromuscular junction induced by soman in isolated non-uniform stretched muscle preparation of rat diaphragm .

结论G蛋白及其介导的cAMP－PKA信号系统参与了缺氧条件下梭曼毒性升高的形成机制。

Conclusion G pro - teins and cAMP-PKA signal transducting system play important roles in the mechanism of increasing toxicity of soman under the condition of hypoxia .

高原缺氧复合梭曼中毒脑Ca~（2+）/CaMPKⅡ活性抑制机理

Mechnism of Inhition of Ca ~ ( 2 + ) / CaM-PK ⅱ after Combined Soman and Hypoxia Injury

模拟4000m高原梭曼中毒犬的血流动力学变化

The effects of soman intoxication at high altitude on hemodynamics in dogs

梭曼、沙林和VX对N-乙酰胆碱受体的作用

Effect of Soman on the Nicotinic Acetylcholine Receptor

M受体阻断剂阿托品可部分阻断梭曼中毒和或缺氧所致的PKA活性的升高。

The muscarinic receptor antagonists atropine could reduce the increase of PKA activity induced by hypoxia or / and soman intoxication .

模拟4000m高原梭曼中毒对大鼠纹状体胆碱能系统的影响

Effects of Soman Intoxication at Simulated High 4000m Altitude on the Cholinergic System in Rats Striatum

目的探讨高原缺氧复合梭曼中毒脑组织中磷脂酶A2（PLA2）、腺苷酸、环磷酸腺苷的变化及其在脑损伤中的作用机制。

Objective To study the mechanism of the effect of PLA 2 on the damage of brain tissues after combined soman and hypoxia injury .

结论[Ca2+]、cAMP、CaM和Ca2+/CaMPKⅡ在缺氧复合梭曼中毒PC12细胞损伤机制中起了重要的作用。

Conclusion [ Ca 2 + ] , CaM , cAMP and Ca 2 + / CaM PK ⅱ exert important role in the damage of PC 12 after combined soman and hypoxia injury .

结果：家兔梭曼中毒后，血清中GSH-Px活性及T-AOC明显降低，而CAT活性明显升高，与正常对照组比较有显著差异（P0.05）。

Results : After soman intoxication , the ( activities ) of serum GSH-Px and T-AOC were obviously decreased , but the activity of CAT was increased ( significantly )( P0.05 ), compared with that in normal control group .

结果与平原中毒组相比，缺氧复合梭曼中毒组皮层和纹状体Bmax增加，海马和纹状体Kd值降低；

Results Compared with those in the soman intoxication group , the M receptor Bmax in the rat cortex and striatum increased and Kd in the hippocampus and striatum decreased markedly .

方法采用放免技术，从细胞水平进一步观察缺氧复合梭曼中毒对PC12细胞的毒性、细胞内[Ca2+]变化、cAMP、CaM和Ca2+/CaMPKⅡ的变化。

Methods The changes of [ Ca 2 + ] , and activity of CaM , cAMP and Ca 2 + / CaM PK II in PC 12 cells were studied after combined soman and hypoxia injury with radioimmunoassay .

结果表明：梭曼对呼吸中枢作用最强、沙林次之、VX最弱且更似乙酰甲胆碱。

The results indicated that the inhibitory effect of Soman on the medullary respiratory centre was much stronger than that of Sarin , while VX was the weakest of three inhibitors .

目的探讨高原缺氧条件下梭曼中毒大鼠心肌抑制性G蛋白α亚基（Giα）mRNA表达的变化。方法实验大鼠随机分为正常对照组、高原缺氧组、平原中毒组和高原中毒组。

Objective To study the expression of myocardium Gi α mRNA after soman intoxication combined high altitude hypoxia in rat . Methods Experimental Wistar rats were randomly divided into four groups : normal control group , high altitude hypoxia group , plain intoxication group and high altitude intoxication group .

无论是开放或密闭条件染毒，乙基梭曼经皮渗透量均比梭曼多。毒剂皮肤染毒后9h，开放条件下，乙基梭曼经皮渗透量是梭曼的7.2倍；

The amount of ethyl soman permeating through skin was 7.2 times as much as that of soman within the experimental time in open type of skin contamination ;

人肝G酶专一性地水解带P-F键的有机磷化合物梭曼，但不催化带P-O，P-C或P-S键的有机磷化合物的反应。

Human liver Gase specifically hydrolyzed organophosphorus compounds bearing P F bond ( soman ), however it did not catalyze the hydrolysis of compounds with P O , P C or P S bonding .

结果：梭曼或乙基梭曼皮肤染毒后，经过约15min的延搁期后经皮渗透量逐渐增加，至2～3h达高峰，之后逐渐下降。

Results : Results of the study showed that the amount of soman or ethyl soman permeating through skin gradually increased after about 15 minutes of delay , reached the peak 2-3 hours later , and then dropped .

采用DTNB显色法，研究平原和模拟4000m高原缺氧条件下梭曼对犬、大鼠组织及全血AChE活力的影响。

DTNB method was used in these experiments to investigate the effect of soman intoxication under high altitude hypoxia on blood or brain acetyl choline esterase ( AChE ) activities compared with that at plain in dogs and rats .