基因毒性

研究发现银纳米颗粒（AgNPs）有一定的细胞毒性和基因毒性，它会引起ROS增加而导致ATP合成异常、DNA损伤、细胞凋亡和坏死等。

Several recent studies have revealed that silver nanoparticles ( AgNPs ) possess the cytotoxicity and genotoxicity by increasing the production of ROS which can cause the interruption of ATP synthesis , DNA damage , apoptosis and necrosis .

结果：马兜铃酸具有肾毒性、消化道毒性、致癌性、致突变性和基因毒性。

RESULTS : Aristolochic acid has nephrotoxicity , alimentary canal toxicity , carcinogenicity , mutagenicity and genotoxicity .

用于核酸损伤和化合物基因毒性检测的新型DNA电化学传感器

Electrochemical DNA Sensor for the Detection of DNA Damage Chemical Toxicity

到目前为止，人类对砷的毒性作用机制还不是很清楚，但存在多种假设：氧化应激，影响细胞增殖，产生基因毒性如影响DNA甲基化、协同致癌、肿瘤促发等。

The exact mechanism of the action of arsenical toxicity is not known clearly , but several hypotheses have been proposed .

结果发现，SO2及其衍生物可引起以上组织细胞的DNA损伤，表明SO2是一种基因毒性因子和染色体断裂剂，它可影响机体免疫系统、中枢神经系统和造血系统的正常功能。

The results suggested that SO2 was a clastogen and genotoxic agent , it could make effects on the function of immune system , neuronal system and hematopoietic .

幽门螺杆菌vacA基因毒性相关片段原核表达载体的构建和表达

Construction and expression of the prokaryotic expression vector of Hp vac A gene related segment with vacuolating activity

彗星试验结果表明重金属污染土壤对蚯蚓产生明显的遗传毒性，并观察到随着暴露时间延长，蚯蚓体内产生DNA修复机制，提示彗星试验是检测土壤基因毒性的有效手段。

The results of the comet assay demonstrated the genotoxicity of metal contaminated soils . And a DNA repair process in earthworm was observed as the exposure time prolonged . And the comet assay is capable of examining the genotoxicity of soils .

有实验研究发现，镉能直接和间接造成基因毒性，例如引起DNA链的断裂、DNA-蛋白交联、氧化DNA损伤和染色体畸形等，这些可能是镉细胞毒性和致癌的重要机制。

It has been found that cadmium could cause genetic toxicity directly and indirectly , such as cause DNA strand break , DNA and protein cross-link , oxidative DNA damage and chromatosome anisotrophy , and those genetic toxicities may contribute to carcinogenesis .

结论随SO2浓度增加，细胞遗传物质损伤加重，且有明确的剂量-效应关系，表明SO2空气污染物是染色体断裂剂和基因毒性因子。

Conclusion With the increase of concentrations of SO2 , the damage of cytogenetic material became more serious and revealed a more clear dose-effect relationship . It suggested that SO2 was a clastogen and genotoxic agent .

但高剂量的ITCs也具有基因毒性，可能引起哺乳动物细胞姐妹染色体交换和染色体失常，从而引起突变和致癌。

But high intake dose of ITCs will bring on genotoxic effects and cause sister chromatid exchanges and chromosomal aberrations in mammalian cells .

饮用塘水基因毒性和致癌性的实验研究

The Experimental Study on Genotoxicity and Carcinogenesis of Drinking Pond Water

利用模拟代谢活化体系研究污染物的基因毒性

Gene Toxicity of Pollutants by Utilizing the Chemical Model of Metabolic Activation System

非基因毒性二氨基类直接染料的合成与研究

Synthesis and Research of Non-genic Toxic Diamines Direct Dye

芳香族污染物基因毒性作用的分子水平研究

The Study on the Genotoxicity of the Aromatic Pollutants at the Molecular Level

提示这些毒素可能是环境中的非基因毒性促癌物。

It suggested that the toxins may be a kind of nongenotoxic carcinogen .

新型根管充填剂&复方牡蛎粉基因毒性的研究

Genotoxicity study of composite oyster shell power as a new root canal filling material

亚硝化对尼古丁基因毒性影响的研究

Effect of Nitrosation on the Genotoxicity of Nicotine

非基因毒性剂引起的癌症中基因外表型遗传性改变

Epigenetic Changes in Cancer Caused by Non-genotoxic Agents

骨炭修复重金属污染土壤和降低基因毒性的研究

Chemical Fixation of Metals in Soil Using Bone Char and Assessment of the Soil Genotoxicity

乙醇引起的基因毒性作用机制尚不十分清楚，通常认为自由基的产生起着十分重要的作用。

It is generally considered that free radical generation plays an important role in the genotoxicity of ethanol .

其健康危害主要包括感官刺激、过敏反应和各种基因毒性。

Its critical health effects on health include sensory irritation , allergenic reaction and a variety of genotoxic actions .

微囊藻毒素还具有基因毒性，Repavich等报道在体外实验中微囊藻毒素导致人类的淋巴细胞染色体异常。

Moreover , microcystins have genotoxicity . It is reported that microcystins induced chromosomal aberrations in human lymphocytes in vitro .

该文就细胞毒性、基因毒性、外遗传毒性这三条基本途径，对电磁辐射引起生物学效应的可能机制作一概要综述。

This thesis summarized some possible mechanisms on the biological effects of electromagnetic radiation , according to cytotoxicity , genotoxicity , epigenetic toxicity .

本实验显示新型根管充填剂复方牡蛎粉无细胞毒性、无基因毒性、无皮肤致敏性以及局部刺激性，具有良好的生物相容性。

The new root canal filling material showed no detected cytotoxic , genotoxic effect , potential of skin sensitization and topical irritation and has good biocompatibility .

采用综合配套的实验研究方法，对广西某肝癌高发区饮用塘水的基因毒性和致癌性进行了系统研究。

The genotoxicity and carcinogenesis of drinking pond water in high incidence area of liver cancer in Guangxi was systematically studied using the systematic experimental methods .

目的：探讨动脉灌注基因毒性抗癌剂顺铂及促凋亡剂咖啡因对骨盆恶性肿瘤治疗的效果。

Objective : To evaluate the effects of genetoxic anticancer agent Cisplatin and promoting apoptosis agent Caffeine in the treatment of pelvic malignant tumors by intra arterial infusion .

生物碳浓度从0%增加至5%时，芘／五氯苯酚的基因毒性分别减弱50%和80%。当生物碳含量增加为10%时，芘／五氯苯酚的基因毒性较5%时有所增加。

The genotoxicity of PYE and PCP was decreased 50 % and 80 % , respectively , when the biochar content increased from 0 % to 5 % .

聚丙烯酰胺本身没有毒性，但其降解后的丙烯酰胺单体具有累积性神经毒性，并且被确定为有基因毒性的致癌物质。

As known to all , the polyacrylamide is non-toxicity and harmless , but the acrylamide monomer produced from polyacrylamide degradation has neurotoxicity , and was determined to be a genotoxic carcinogen .

目的：探讨苯对小鼠骨髓细胞DNA基因的毒性作用。

Objective : To study the toxicity of benzene inhalation on DNA of bone marrow cells in mice .

水稻黄单胞杆菌水稻变种rpfA基因与毒性相关

The rpfA gene of Xanthomonas oryzae pv oryzae involved in the pathogenicity