固醇

在动物实验和人体临床实验中发现植物固醇具有降低总胆固醇和LDL胆固醇的作用。

It has been found that plant sterol exhibits cholesterol lowering effects on total cholesterol and LDL-cholesterol in both animal studies and clinical trials .

临床实验的结果表明，每日摄入12g的植物固醇可以达到降低州10%15%的血清胆固醇的作用。

Numerous clinical trials indicate that daily intake of 1-2 g plant sterol will be beneficial for 10 % - 15 % serum cholesterol lowering .

粪便中总固醇和酸性固醇的净排出量显著增加（均为P＜0.01）。

The acidic steroids in bile and feces and the total steroids in feces were significantly increased ( P < 0.01 , respectively ) .

C57BL/6小鼠胆结石形成中固醇载体蛋白2的mRNA水平和胆固醇饱和指数增高

MRNA of SCP 2 and cholesterol saturation index are increased during gallstone formation in C57BL / 6 mice

富铬酵母不仅含铬量高，还含有丰富蛋白质、核酸、糖原、脂肪、生物素、多种B族维生素、固醇和其他多种微量元素，因此具有很高的营养价值。

Chromium yeast has not only plentiful organic chromium but also abundant protein 、 nucleic acid 、 hepatin 、 fat 、 biotin 、 Vitamin B 、 viosterol and other trace elements .

目的：采用HPLC-ELSD法测定复合磷脂固醇脂质中磷脂酰胆碱（PC）的含量。

Objective : To determinate phosphatidylcholine ( PC ) in Phospholipid Cholesterol Complx Lipids by HPLC-ELSD .

结果冠心病组的甘油三酯、总脂固醇、低密度脂蛋白明显对照组增高（P0.05）。

Results The level of triacylglycerol ( TG ), total cholesterol and low density lipoprotein ( LDL ) for the CHD were higher significantly ( P0.05 ) .

目的探讨植物固醇酯（PSE）对大鼠血脂水平的影响。

Objective To observed the effects of phytosterol ester ( PSE ) on serum lipid level in rats .

并测定治疗前后尿17-羟类固醇和17-酮类固醇和血清LH、FSH、E2、PRL、TSH和孕酮（P）水平。

Before and after treatment , the 17-KS and 17-OHCS in urine and LH , FSH , E2 , RPL , TSH and progesterone in serum were detected .

SRA基因是一种类固醇激素受体的转录辅激活因子，也是首次发现的可以从RNA和蛋白质两个水平上发挥作用的分子。

SRA , a steroid receptor coactivator , is the first found molecule that has the unusual property to function both at the RNA and the protein levels .

苜蓿皂甙组粪便中总固醇和酸性固醇净排出量均显著增加。与正常对照组比较，苜蓿皂甙处理1h、2h、4h各组NO的释放均显著增加。

Compared with normal control , the NO release of HUVEC was significantly increased in Alfalfa saponin group after treatment for 1 h , 2 h or 4 h.

固醇调节元件结合蛋白裂解激活蛋白（SCAP）的研究进展

Research Advance in SREBP Cleavage Activating Protein

用聚氨脂海绵对人尿内17－酮类固醇（17－KS）和17－羟皮质类固醇（17－OHCS）进行分离和富集。

Using foam rubber 17-ketosteroid ( 17-KS ) and 17-hydroxycorticosteroid ( 17-OHCS ) were separated and collected in urine .

采用大气压化学电离源（APCI）正离子模式，实现了黑线姬鼠粪便中4种类固醇化合物的定性及定量测定。

The identification of steroid derivatives is performed under atmospheric - pressure chemical ionization ( APCI ) source in positive-ion mode .

Voltaren是口服非固醇抗炎药的商标名。

Voltaren is the trade name of the nonsteroidal anti-inflammatory drug that is administered only orally .

低密度脂蛋白受体（LDLR）调节体内胆固醇的平衡是通过其启动区的固醇调节元件（SRE）感受体内胆固醇的变化，从而调控LDLR基因的表达来实现的。

The sterol response element ( SRE ) of the LDL receptor promoter is responsible for normal sterol regulation and the expression of LDLR gene .

固醇调节元件结合蛋白（Sterolregulatoryelementbindingproteins，SREBPs）属于碱性螺旋-环-螺旋亮氨酸拉链（bHLH-zip）转录因子家族，是真核细胞内调节脂肪代谢的关键转录因子。

Sterol regulatory element binding proteins ( SREBPs ) belong to the transcription factor family of basic helix-loop-helix leucine-zipper ( bHLH-zip ) . They are the key transcription factor in eukaryotic cell which regulates lipid metabolism .

这些资料表明胆汁酸合成过程中过氧化物酶体内固醇侧链的β-氧化由DBP催化，DBP为胆汁酸合成所必需。

From these evidences , we can draw a conclusion that DBP takes part in the β - oxidation reactions of cholesterol side chains and it is a necessary enzyme for bile acid synthesis .

罗琴科夫自称发明了一种类固醇和酒的混合溶液——报告称，俄罗斯体育官员称其为“公爵夫人”（Duchess）鸡尾酒——并提供给了运动员。

Rodchenkov said he created a mixture of steroids and liquor - known as " the Duchess " cocktail among Russian sports officials , according to the report - that was provided to athletes .

结论Hcy诱导的内质网应激可引起SREBP-1C、GRP-94的表达变化及内源性固醇调节通路失调。

Conclusion Hcy-induced endoplasmic reticulum stress causes the expression change of SREBP-1C and GRP-94 , the dysregulation of the endogenous sterol response pathway .

一种非固醇抗炎药（商标是Daypro）。

A nonsteroidal anti-inflammatory drug ( trade name Daypro ) .

该酶被认为催化了固醇生物合成、环丙烷和环丙稀脂肪酸生物合成、环丙烷脂肪酸（CFA）生物合成等三个代谢通路中的四个反应。

This protein was thought to be able to catalyze 4 reactions in 3 different pathways , sterol biosynthesis , cyclopropane and cyclopropene fatty acid biosynthesis , cyclopropane fatty acid ( CFA ) biosynthesis .

类固醇受体辅助活化因子-1（steroidreceptorcoactivator-1，SRC-1）是脑内分布最广泛的类固醇受体辅助活化因子，参与了雌激素受体、雄激素受体等多种类固醇受体对把基因转录的调节。

Steroid receptor coactivator-1 ( SRC-1 ) is the most widely distributed steroid receptor coactivator in the brain . It participate the regulation of several kinds of steroid receptors for gene transcription .

目的探讨TNF-α对油酸诱导的脂肪变性肝细胞模型固醇调节元件结合蛋白1c（sterol-regulatoryelementbindingprotein-1c，SREBP-1c）mRNA的表达及甘油三酯（triglyceride，TG）含量的影响。

Objective To explore the effects of TNF alpha on the expression of sterol-regulatory element binding protein-1c , SREBP-1c mRNA and the content of triglyceride ( TG ) in the models of cultured steatosis hepatocytes .

方法：真菌与不同浓度氟康唑温育24h后计数、称量、皂化，提取真菌中难皂化脂，薄层层析，扫描测定其中的麦角固醇和羊毛固醇含量。

Methods : Saponification and extraction of the nonsaponifiable lipids ( NSLs ) of fungi were carried out after 24 h of incubation with varied concentrations of fluconazole . The components of the NSLs were separated by TLC and the concentrations of ergosterol and lanosterol were determined .

目的：为探讨固醇调节元件结合蛋白-2（SREBP-2）基因1784G>C位点多态性与高胆固醇血症人群膳食干预效果的关系。

Objective : To investigate the relations between Sterol - Regulatory Element-Binding Protein-2 ( SREBP-2 ) gene 1784G > C polymorphism and dietary intervention predisposition in hypercholesterolaemia population .

一种类固醇激素，其组成为C21H30O3，由肾上腺皮质分泌，也可人工合成，用于治疗肾上腺分泌不足。

A steroid hormone , C21H30O3 , secreted by the adrenal cortex or produced synthetically and used to treat adrenal insufficiency .

Dio是合成各种甾体类药物的前体化合物，作为一种类固醇，其对免疫功能具有广泛的作用，具有促进TNF-α分泌，抑制IgE产生，上调调节性T细胞等作用。

Dio is a precursor compound to synthesize various steroidal drugs . As a steroid , it has a wide range of effects on immune function , such as inducing the TNF-a secretion , suppressing IgE production , and up-regulating T regulatory cell production .

Ezetimibe是一种新型选择性肠胆固醇吸收抑制剂，通过抑制肠上皮细胞的胆固醇吸收蛋白NPC1L1减少胆固醇、植物固醇的吸收以及胆汁胆固醇的再吸收，从而降低血浆固醇水平。

Ezetimibe , a new selective cholesterol absorption inhibitor , may decrease the absorption of cholesterol and plant sterol by inhibiting the cholesterol absorption protein Niemann-Pick C1 like 1 ( NPC1L1 ) in the enterocytes .

为了探索植物固醇在纤维发育中的作用及其机制，本论文从棉花纤维中克隆了C-4去甲基复合酶体中的3p-羟基类固醇脱氢酶基因（Gh3β-HSD）。

To understand the effect and mechanism of phytosterols in fiber development , the3 β - hydroxysteroid dehydrogenase ( 3 β - HSD ), a member of the complex genes was cloned from cotton fiber ( Gh3 β - HSD ) .