嘌呤核苷

目的：探讨大鼠肝脏低温保存及常温缺血再灌注过程中，不同保存液中嘌呤核苷磷酸酶（PNP）活性的变化。

Objective : To study the change of purine nucleoside phosphorylase ( PNP ) during ischemia and reperfusion in rat liver .

嘌呤核苷磷酸化酶/氟达拉滨（PNP/fludarabine）自杀基因系统对人肝癌细胞系BEL7402体外杀伤效应的研究

Study on Killing Effects of Purine Nucleoside Phosphorylase / Fludarabine ( PNP / fludarabine ) Suicide Gene System on Human Hepatocellular Carcinoma Cell Line BEL7402 in vitro

利巴韦林（Ribavirin）是一种嘌呤核苷类似物，具有广谱抗病毒作用。对多数DNA、RNA的复制有抑制作用。

Ribavirin , an antiviral agent of nucleoside analog , has wide efficacy against virus and restrains lots of DNA and RNA copy .

目的分别构建三种启动子调控的大肠杆菌嘌呤核苷磷酸化酶（PNP）基因表达载体，检测、分析三者的表达差异。

Objective To construct three expression vectors harboring PNP ( purine nucleoside phosphorylase ) gene under three different promoters .

目的：探讨大肠杆菌嘌呤核苷磷酸化酶自杀基因对胃癌细胞MKN-45的抑制及杀伤作用，并证实旁观者效应。

Objective To study the effects E.coli purine nucleoside phosphorylase suicide gene on human gastric cancer MKN-45 cells as well as the bystander effect .

以淋巴细胞减少症和发育缓迟为临床表现的嘌呤核苷磷酸化酶缺陷（PNPdef）1例：经脐带血移植得以成功治疗

Purine nucleoside phosphorylase deficiency ( PNPdef ) presenting with lymphopenia and developmental delay : Successful correction with umbilical cord blood transplantation

肝脏缺血再灌注损伤大鼠嘌呤核苷磷酸酶活性的研究

Activity of purine nucleoside phosphorylase during ischemia and reperfusion in rat liver

酶法合成6-氯嘌呤核苷

Enzymatic Synthesis of 6-Chloro-purine Riboside with Lactobacillus Helveticus Enzyme mimics

基于毛细管电泳在柱酶微反应器技术筛选嘌呤核苷磷酸化酶抑制剂

Purine nucleoside phosphorylase inhibitor screening using immobilized enzyme reactor by capillary electrophoresis

嘌呤核苷磷酸化酶基因的克隆及原核表达载体的构建

Cloning and expression of purine nucleoside phosphorylase in Escherichia coli

γ线对人的红细胞嘌呤核苷磷酸化酶的影响

Effect of gamma irradiation on the activity of human erythrocyte purine nucleoside phosphorylase

γ射线对红细胞嘌呤核苷磷酸化酶的影响二、酶的某些性质

Effect of irradiation on erythrocyte purine nucleoside phosphorylase 2.some properties of the enzyme

芽胞杆菌生产嘌呤核苷研究进展

Progress on Manufacturing Purine Nucleoside with Bacillus genus

酶法合成6-氯嘌呤核苷利用细菌发酵生产玉米素的研究

Enzymatic Synthesis of 6-Chloro-purine Riboside with Lactobacillus Helveticus Fermentation process of zeatin production by bacterium

6－巯基嘌呤核苷注射液的稳定性研究

Stability study of 6 - mercaptopurine injection

合成利巴韦林的关键酶嘌呤核苷磷酸化酶的原核表达及活性分析

Prokaryotic Expression and Functional Analysis of Purine Nucleoside Phosphorylase of the Key Enzyme for Ribavirin Produced

肌苷属于嘌呤核苷，是食品和医药行业广泛应用的重要产品。

As a purine nucleoside , inosine is an important product in food and medicine industry .

嘌呤核苷（酸）衍生物的合成及其性质研究莽草酸衍生的新型核苷类似物的合成研究

Synthesis and Properties of Purine Nucleoside and Nucleotide Derivatives ; New Nucleoside Analogues from Shikimic Acid

嘌呤核苷类似物的合成研究一直是一个非常活跃的科研领域。

The synthesis of natural nucleoside analogues has been being an active field for pharmaceutical chemists .

冷适应对大鼠棕色脂肪组织线粒体内膜解偶联蛋白与嘌呤核苷三磷酸结合的影响

Effect of cold acclimation on GTP binding to uncoupling protein in mitochondria inner membrane of rat brown fat

离体与整体照射对大鼠红细胞嘌呤核苷磷酸化酶活力与红细胞膜脂质过氧化值的影响

Effect of gamma irradiation on erythrocyte purine nucleoside phosphorylase activity and erythrocyte membrane lipid peroxidation in vitro and in vivo

嘌呤核苷化合物在抗病毒、抗肿瘤以及抗血小板凝集等方面具有广泛的应用，引起了药学和化学工作者的广泛关注，成为有机化学和药物化学的重要研究领域。

Purine nucleoside compounds have a wide range of applications in the field of anti-virus , anti-tumor and anti-platelet aggregation and so on .

嘌呤核苷及其衍生物由于在抗病毒、抗肿瘤及抗血栓等领域具有很好的药用价值而受到人们的广泛关注，这类衍生物的合成为发现生物活性更好的药物提供依据。

Purine nucleoside analogs , as a class of important medicinal compounds , have been widely used in medical fields , such as antivirus , anticancer , anti-thrombosis and so on .

嘌呤核苷磷酸化酶是嘌呤核苷补救代谢途径中的关键酶，在抗肿瘤基因治疗、核苷类药物合成等方面具有广泛的应用。

Purine nucleoside phosphorylase ( PNPase , E.C.2.4.2.1 ) is a key enzyme in the purine salvage metabolic pathway . It could catalyze the synthesis of nucleosides , and has great potential in anti-tumour gene therapy .

很多嘌呤衍生物核苷都具有较强的生理活性。7-去氮嘌呤核苷已从自然界分离，确定结构及全合成。

Many nucleosides of purine derivatives possess high biological activities .

此外，一些新型目标产物既丰富了嘌呤及嘌呤核苷衍生物又具有潜在的生理活性。

Besides , some new products both enrich the world of purines and purine nucleosides and potentially behave biological activities .

C~6修饰的嘌呤及嘌呤核苷具有广泛的生理活性，成为近年来研究的热点。

C6-modified purines and purine nucleosides exhibit a variety of biological activities and have attracted much interest in recent years .

目的探讨柴黄益肾方提取物（CYE）对嘌呤霉素氨基核苷（PAN）肾病大鼠尿蛋白及纤溶功能的影响。

Objective : To investigate the effects of Chaihuang-Yishen Formula Extract ( CYE ) on urinary protein and the function of fibrinolysis of rats with nephrosis induced by puromycin aminonucleoside ( PAN ) .

给大鼠注射puromycinaminonucleoside（PAN）所建立的肾病模型应该称为嘌呤霉素氨基核苷肾病（PAN肾病），但在国内却多被误为嘌呤霉素肾病。

The nephropathy model induced by puromycin aminonucleoside ( PAN ) in rats should be named puromycin aminonucleoside nephropathy or PAN nephropathy , however , the domestic scholar used to call it as " puromycin nephropathy " .

不规则趋化蛋白在嘌呤霉素氨基核苷肾病模型中的表达

Expression of fractalkine in rats with puromycin aminonucleoside nephropathy