亲核取代

而当R为吸电子基团-CHO、-COCH3时，主要发生分子内氮原子上的亲核取代反应，产物为含氮的五员杂环化合物。

In contrast , electro-withdrawing groups CHO and COCH_ 3 on the attacking site will favor the intramolecular nucleophilic substitution of nitrogen and form 5-membered heterocyclic compounds .

Vicarious亲核取代反应研究进展

Recent progress on Vicarious nucleophilic substitution reaction

用亲核取代法测定La（Ⅲ）&丹宁配合物的稳定常数

The determination of the stable constant of the complex compound of La (ⅲ) & tannin by affinity nucleus replacement

配合物亲核取代的机理阴阳离子复合掺杂LiMn2O4的结构与性能研究

Study on Structure and Property of Anion - cation Compound Substituted LiMn_2O_4

卤代烷亲核取代反应的一种新机理&S（RN）1

A New Mechanism of Nucleophilic Substitution Reactions for Alkyl Halides & S_ ( RN ) 1

HEMA在亲核取代及后处理过程中，酯键会发生水解，造成侧链上部分双键的丢失。

Hydrolysis of ester groups of HEMA occurred during the nucleophilic substitution reaction and post-processing .

提出自由基IPSO亲核取代反应机理。

A radical IPSO substitution mechanism is proposed .

介绍了18F标记的脑受体PET显像剂制备的一般方法，对亲核取代法进行了较为详细的讨论，分析了主要影响因素；

This paper reviews the common methods for preparing Fluorine-18 labelled radiopharmaceuticals for brain receptor imaging , with particular emphasis on nucleophilic routes .

综述了近年应用于药物合成的微波促进的反应类型，包括环合、不对称烷基化、Suzuki偶合、还原和氧化、亲核取代等。

Some microwave-accelerated reactions such as cyclization , stereo-selective alkylation , Suzuki coupling-reaction , reduction , oxidation and nucleophilic substitution are reviewed .

芳香族硝基化合物与苯硫酚钠盐的亲核取代反应&自由基IPSO取代机理

Studies on the Reaction of Aromatic Nitro Compounds with Sodium Phenylthiolate & Radical IPSO Substitution Mechanism

在亲核取代反应中；无论按SN1历程还是SN2历程，烯丙式卤代烃的反应速度都是最快的。

In the substitution reaction of nucleophilic , whatever we use S_N1 or S_N2 reaction course , the rate of reaction is the most rapid .

最终产物的ee值与中间体α-羟基酮十分接近，表明在所发生的亲核取代反应中基本没有消旋化得现象发生。

The ee values of the final products were very close to those of α - hydroxy ketones , which indicated that no racemization occurred in the substitution .

本文综述了模板DNA指导的多种类型的有机合成反应，包括还原胺化、亲核取代、Henry、Wittig烯化、光化学连接以及多步小分子的合成等反应；

The numerous types of DNA-templated organic synthesis , including reductive amination , nucleophilic substitution , Henry , Wittig olefination , photochemical ligation and multistep small-molecule synthesis , etc , are reviewed .

方法应用小型回旋加速器，通过18O（p，n）18F核反应生产出18F离子，由亲核取代反应制备18F-FDG，并对所制备的18F-FDG注射液进行质量控制。

METHODS 18F-FDG was synthesized via nuclear reaction 18O ( p , n ) 18F on 18O-enriched water and nucleophilic substitution reaction by Tracerlab Mx FDG synthesis system .

这套客观的取代基常数用之于芳香亲核取代反应不比Miller从该反应系中求出的数值差。

This set of objective substituent constants can also be applied to aromatic nucleophilic substitution not any less adequately than that derived by J. Miller right from this very type of reactions .

亲核取代法制备CEM的后处理简单、所需氯乙基咔唑原料易得（采用微波法合成）。

The nucleophilic substitution method has the simple aftertreatment procedure and the raw material of chlorine ethyl carbazole ( by microwave ) easy obtaining .

水解反应的可能机理是SNl和SN2.双分子亲核取代反应立体化学问题释疑

The mechanisms of the hydrolysis were proposed to be unimolecular nucleophilic substitution and bimolecular nucleophilic substitution ( SN2 ) . On the Problem of Bimolecular Nucleophilic Substitution Reaction Sterochemistry

氢的替代亲核取代反应（VNS）是与硝基芳环的亲电反应、亲核反应不同的一种新反应。

Vicarious nucleophilic substitution ( VNS ) of hydrogen is a new type of reaction which is differ-ent from the usual electrophilic and nucleophilic reactions of the nitro arenes .

Cl原子在反应进程中是给电子的，因此，氯自由基与2-氯吡啶反应是亲核取代的SN2机理。

During the whole reaction processing , the Cl · acted as a nucleophilic specie , donating the electron . Therefore , S_N2 mechanism was speculated for the reaction of Cl · with 2-chloropyridine .

Vicarious亲核取代氢反应（VNS）是用α-位含有离去基的功能化的负碳离子在强碱存在下取代硝基芳环（含芳杂环）上氢的反应。

Vicarious Nucleophilic Substitution of hydrogen ( VNS ), the hydrogen on the carbo-and heterocyclic nitroarenes was substituted by functional carbanions containing leaving groups (α & place ) in strong base conditions .

（ArNu）~-的奇电子配置和直接光亲核取代

Residence of the Odd Electron of ( ArNu ) ~ - and Straight Photo-nucleophilic Substitution

以磷酰氯为原料通过与手性仲胺的亲核取代反应高产率地合成了手性HMPA类似物。

The chiral HMPA analogues 1 and 2 were prepared in high yield by nucleophilic substitution between the chiral secondary amine and phosphoryl chloride .

然后F-AQN-OPEG-OMe与奎尼丁的锂盐再进行亲核取代反应，以91.7%的产率得到新型手性配体QD-AQN-OPEG-OMe。

Then , QD-AQN-OPEG-OMe was synthesized in 91.7 % yield by reaction of F-AQN-OPEG-OMe with the lithium salt of quinidine .

它与环氧树脂混合后首先形成过渡状态，然后按双分子亲核取代（SN2）机理进行开环反应。

After it was mixed with epoxy resin , transition state was formed first . Then they got on with opening ring reactions according to bimolecular nucleophilic substitution mechanism ( S N2 ) .

核磁跟踪测试表明，HCCP和BPS进行的是双分子亲核取代反应（SN2），三乙胺（TEA）在反应中不仅作为缚酸剂，而且还起着活化BPS、促进亲核进攻的作用。

1H NMR monitor of the polycondensation showed that TEA acted as not only acid-acceptor but also catalyst to activate BPS for nucleophilic substitution . And condensation between HCCP and BPS followed a bimolecular nucleophilic substitution ( S_N2 ) pattern .

由于单分子亲核取代反应（SN1）经过了碳正离子中间体的历程，所以得到的产物是外消旋的。

In the reaction mechanism of unimolecular nucleophilic substitution ( SN1 ), it can produce carbocations which can easily lead to the racemization of the products .

进行了动力学研究，获得了反应活化能和各反应温度下的反应速率常数，同时研究结果表明烯丙基化反应级数为2，反应机理为SN2亲核取代反应。

The activation energy and rate constant of the allylation reaction was calculated in virtue of kinetic study . The kinetics study indicated that the allylation reaction of polyether was second order and its reaction mechanism was SN2 nucleophilic substitution .

氢键活化的苯环上C-F键的亲核取代反应研究亲核取代法制备壳聚糖6-OH固载环糊精衍生物

Study of Nucleophilic Substitution Reaction of C-F Bond on a Benzene Ring under Activation of Hydrogen Bond PREPARATION OF CHITOSAN IMMOBILIZED WITH β - CD AT C_6 POSITION BY A NUCLEOPHILIC DISPLACEMENT REACTION

方法使用小型回旋加速器生产18F离子，经亲核取代、手性相转移催化烷基化等4步反应，合成得到无载体的618FDOPA。

Methods No-carrier-added ~ 18F was produced by a mini cyclotron and used as the radiolabeling reagent . 6 - ~ 18F-DOPA was successfully prepared after four reactions ( nucleophilic substitution , reductive iodination , chiral phase-transfer catalysis and hydrolysis ) .

苯甲酰氯亲核取代反应的热动力学研究

Study on the thermokinetics for nucleophilic substitution reactions of benzoyl chloride