青霉烷
- 网络penam;gibberellane;penams;penan
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用HPLC法测定6-氨基青霉烷酸色谱条件的探索
Developing the Analytical Methods of 6-Amino Penicillanic Acid by HPLC
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通过确定苯乙酸、青霉素G在离子交换柱中的动力学行为和固定化酶的动力学参数,利用已建立的数学模型,可很好地对青霉素G水解生产6-氨基青霉烷酸过程进行计算机模拟。
Based on Phenylacetic acid and Penicillin G dynamics in ion exchange process and immobilized enzyme kinetics , the hydrolysis of Penicillin G was simulated well by computer from the mathematical model developed .
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研究齐墩果醇酸(oleanolicacid,OA)对6-氨基青霉烷酸APA-蛋白致敏豚鼠过敏休克的对抗作用。
Reduction of histamine contents . To study the antagonistic effect of oleanolic acid ( OA ) on anaphylactic shock in guinea-pigs sensitized with 6-aminopenicillanic acid ( APA ) - protein .
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目前PGA主要催化水解青霉素G生成6-氨基青霉烷酸(6-aminopenicillanicacid,6-APA)及苯乙酸,6-APA是工业上半合成β-内酰胺类抗生素的关键中间体[13]。
PGA catalyze the hydrolysis of benzylpenicillin to phenylacetic acid and 6-aminopenicillanic acid-one of the key intermediates for the production of semisynthetic β - lactam antibiotics .
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青霉素酰化酶酶活可以利用荧光胺和6-氨基青霉烷酸(6-APA)反应加以测定。
The reaction of 6 - aminopenicillanic acid with fluorescamine can be used to determine penicillin acylase activity .
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测定了苯乙酸(PAA)在纯水和水乙醇、水丙醇混合溶剂中的溶解度以及6-氨基青霉烷酸(6-APA)在PAA溶剂中的萃取动力学。
The solubility of phenoxyacetic acid ( PAA ) in water , water-ethanol , water-acetone and the extraction kinetics of 6-aminopenicillanic acid ( 6-APA ) in PAA was measured .
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考察了青霉素G,丙酮和苯乙酸(PAA)杂质在6氨基青霉烷酸(6APA)结晶过程中对晶习的影响及其在乙醇溶液中的生长过程。
The effects of impurity of penicillin G , acetone and phenoxyacetic acid ( PAA ) on habit of 6-aminopenicillanic acid ( 6-APA ) in the process of its crystallization and the growth of 6-aminopenicillanic acid in the solution of ethanol are studied .
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6-氨基青霉烷酸(6-APA)是生产各种半合成青霉素的原料,在半合成抗生素工业中占据着重要地位。
6-aminopenicillanic acid ( 6-APA ) is a precursor for the synthesis of semi-synthetic penicillins and a critical element in the production of semi-synthetic β - lactam antibiotics .
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用静态法研究了6-氨基青霉烷酸在弱碱性阴离子交换树脂IRA67上的吸附行为。
The adsorption behavior of6-aminopenicillanic acid ( 6-APA ) on weak basic anion exchange resin IRA67 was studied .
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6-氨基青霉烷酸(6-APA)是半合成β-内酰胺抗生素的关键中间体,年产量在10000吨以上,酶法水解青霉素是生产6-APA的重要途经。
6-aminopenicillanic acid ( 6-APA ) is a key intermediate for production of semi-synthetic β - lactam antibiotics . It is produced industrially at a scale of 10,000 ton / year .
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而青霉素酰化酶是一种重要的工业用酶,用来催化青霉素盐去酰化反应,得到制备半合成青霉素的必需中间体6-氨基青霉烷酸(6-APA)。
The two layered materials were used as supports for the immobilization of penicillin G acylase ( PGA ), which is an important enzyme for catalysis of the deacylation of penicillin to afford a necessary intermediate in the manufacture of semisynthetic penicillins .
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用固定化细胞裂解苄基青霉素制备6-氨基青霉烷酸
Production of 6 - aminopenicillanic acid from benzylpenicillin by immobilized E.coli cells
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青霉烷酸衍生物构效关系的理论计算与研究
Theoretic calculation and study on structure-activity relationship of penicillin derivatives
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6-氨基青霉烷酸晶体生长过程中杂质对晶习的影响
Effect of Impurity on the Crystal Habit of 6-aminopenicillanic Acid During Its Growth
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乙醇、甲醇对6-氨基青霉烷酸结晶条件的影响
Effect of ETHYL-OR methyl alcohol on the crystallization condition of 6-amino penicillanic acid
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过饱和度和温度对6-氨基青霉烷酸生长晶习的影响
Effect of Supersaturation and Temperature on the Crystal Habits of 6 - Aminopenicillanic Acid
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6-氨基青霉烷酸衍生物的研究Ⅰ.6-(取代丙烯酰氨)青霉烷酸的合成
Derivatives of 6-aminopenicillanic acid ⅰ . synthesis of 6 - ( substituted acrylamido ) penicillanic acid
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本文较详细地研究了乙醇、甲醇对6-氨基青霉烷酸结晶条件的影响。青霉素裂解液中加入一定量的乙醇或甲醇可防止苯乙酸的结晶。
We studied the effect of ethyl - or methyl alcohol on the crystallization condition of 6-Aminopenicillanic Acid in detail .
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目的改进β-内酰胺酶抑制剂泰唑巴坦关键中间体2α-甲基-2β[(1,2,3-三唑-1-基)-甲基]青霉烷酸砜二苯甲酯(Ⅰ)的合成。
Objective To modify the synthesis of Benzhydryl 2 α - methyl-2 β - [ ( 1,2,3 - triazol - 1-yl ) - methyl ] penicillanate-1,1-dioxide ( ⅰ ), the key intermediate of β - lactamase inhibitor tazobactam .