色素脱失

组织染色结果显示，激光治疗后与周边太田痣组织相比，色素脱失部位色素颗粒减少，而色素细胞的数量没有明显变化。

Tissue staining showed that compared to the surrounding Ota tissue , the spot of hypopigmentation has fewer melanin granule , but the melanocytes has no obvious change .

白癜风是一种色素脱失性疾病，目前病因不明，缺乏特异性治疗。

Vitiligo is a skin depigmentation disorder of unknown etiology , without specific treatment .

白癜风皮损局部存在着由补体参与的免疫反应，并最终形成攻膜复合体（C5b-9）；这种异常的免疫反应可能是导致黑素细胞破坏，局部色素脱失的原因之一。

Conclusion According to our results , we postulated that there was an abnormal immune reaction in vitiligo lesions , which was associated with complements and then formed membrane attack complex ( C5b-9 ) .

这说明氢醌建立色素脱失模型更好。

This result may indicate that Hydroquinone is better for establishing the bleaching model .

目的白癜风是一种以皮肤色素脱失为主要表现的获得性、色素障碍性疾病。

Objective Vitiligo is an acquired disorder of depigmentation characterised by the loss of pigment from epidermis .

背景：白癜风是一种获得性的皮肤色素脱失性疾病。

BACKGROUND : Vitiligo is an acquired skin disorder caused by the disappearance of pigment cells from the epidermis .

本实验结果为乙烯雌酚临床应用于治疗色素脱失性疾病提供了理论基础和实验依据。

The study provides a theoretical basis and experimental evidence to diethylstilbestrol used to the depigmentation disease therapy at clinical .

方法：1、分别采用过氧化氢和氢醌两种脱色法建立色素脱失动物模型并对两种方法进行比较。

Hydrogen peroxide and hydroquinone were used to establish two depigmentation models in animals which were then compared . 2 .

结果：局部病变组织皲裂及溃疡全部愈合，萎缩、瘙痒、色素脱失及增生等症状均有好转。

Results : The rhagadia and ulcer were all healed , and the atrophy , pruritus , depigmentation and hyperplasia were all improved .

白癜风是由于皮肤和毛囊的黑素细胞内酪氨酸系统的功能减退、丧失引起的，是一种以局限性或泛发性皮肤色素脱失为特征的疾病。

Vitiligo is a condition in which the tyrosine system in pigment cells are destroyed , resulting in irregularly shaped white patches on the skin .

目的：1、两种色素脱失模型方法的建立和比较，为进一步研究提供最佳模型。

Purpose : 1 . Establishment and comparison of two models of depigmentation in animals to select the best one for further studies . 2 .

结果：2例患者的皮肤色素脱失处基底层均未见黑素颗粒，符合白癜风的病理改变；

Results : There was no melanin granule in basal cell layer in depigmented skin of 2 cases , which coincided in the pathogenic change of vitiligo .

目的：白癜风是一种常见的后天性色素脱失性皮肤黏膜病，我国人群发病率约为0.1%-2%。

Objective : Vitiligo is a common acquired depigmentation of the skin and mucous membrane disease , the incidence rate of population is about 0.1 % to 2 % .

白癜风是一种常见的色素脱失性皮肤病，全世界发病率约为1%-2%[1]。

Vitiligo is an acquired and progressive disorder manifested by circumscribed depigmented patches on the skin . It affects approximately 0.1 to 2.0 % of the world population [ 1 ] .

白癜风是一种难治性因皮肤表皮黑素细胞消失或缺失而造成的局部或泛发性色素脱失性皮肤疾病，全球发病率达0.1-2%。

Vitiligo is a common skin disease with local or generalized depigmentation attributed by disappearance or loss of epidermal melanocytes , and hard to cure . Its incidence worldwide is 0.1-2 % .

白癜风是一种常见的慢性色素脱失性皮肤病，近年来发病率有增多的趋势，但其病因及发病机制至今仍尚未完全明确。

Vitiligo is known as a chronic , common depigmentation disorder . In recent years , the incidence rate is growing . However , the etiology and pathogenesis of vitiligo is still not completely known yet .

结果6例AD中有3例临床合并帕金森综合征，其黑质、蓝斑均有不同性质及程度的损伤，2例系非特征性色素细胞脱失伴胶质细胞增生，1例为球形体色素变性。

Results Coexistent Parkinsonism was present in 3 cases of AD. Pathological examination revealed nonspecific degeneration , including pigmented neuronal loss and gliosis in substantia nigra and locus ceruleus in 2 cases and spheroid pigmentary degeneration in one case .

黑素细胞生成黑素的不足可以导致皮肤色素减退或脱失，促进黑素细胞的黑素生成是治疗色素脱失性疾病的策略之一。

The insufficient melanogenesis in melanocytes may result in hypopigmentation of the skin , and promotion of the melanogenesis in melanocytes is a strategy in treating depigmenting disorders .

结论壳聚糖-明胶膜片是支持人黑色素细胞生长的良好材料，这一体系为色素脱失症的治疗提供了新的途径。

Conclusions We have found chitosan-gelatin membrane is a good material support growth of melanocytes . This system may provided an alter approach for treatment of pigment loss .

白癜风是一种色素生成障碍性皮肤病，症状为皮肤出现局限性或泛发性色素脱失斑，皮损处黑色素的生成减少或消失。

Vitiligo is a pigmentation disorder disease , the clinical presentation is circumscribed or generalized depigmented macule , melanin decreases or loses in epidermis .