膜融合

副粘病毒F蛋白特异性膜融合功能的研究

Study on the Specific Membrane Fusion of Fusion Protein of Paramyxoviruses

副粘病毒科病毒的膜融合是由其表面糖蛋白，F蛋白介导的。

Membrane fusion within the Paramyxoviridae family of viruses is mediated by a surface glycoprotein termed the " F ", or fusion protein .

阳离子膜融合脂质体包裹DNA体外转染和稳定性研究

Studies on transfection efficiency of cationic fusogenic liposomes mediated DNA and stability of the complexes

prM蛋白和E蛋白是蜱传脑炎病毒的包膜蛋白，E蛋白可以诱导保护性抗体，具有与受体结合、细胞膜融合的功能和血凝活性。

E protein could induce protective antibody , which had the function of receptor-binding and cell-membrane fusion and blood coagulation activation .

膜融合使病毒蛋白及病毒RNA基因组释放到宿主细胞内而感染宿主。

The membrane fusion process leads to the release of viral proteins and the RNA genome into the host cell , initiating an infection cycle .

在HA（血凝素）介导的病毒膜融合和病毒粒子感染过程中，NA（神经氨酸酶）发挥了重要功能。

In the HA ( hemagglutinin ) - mediated virus membrane fusion and virus particles during infection , NA ( neuraminidase ) played an important function .

SNARE蛋白核心复合体是膜融合的分子基础，为膜融合提供能量。

SNARE core protein complex is the molecular basis for membrane fusion to provide energy for membrane fusion .

杆状病毒的出芽型病毒粒子（buddedvirions，BV）有两类截然不同的膜融合蛋白。

Two distinct envelope fusion proteins are identified in baculovirus budded virions ( BV ) .

作为JEV的病毒吸附蛋白（virusattachmentprotein，VAP），E蛋白介导JEV与宿主细胞受体结合及膜融合。

Since E protein is known as the viral attachment protein ( VAP ), it contains structural and functional elements that participate in the virus-host cell receptor interaction and membrane fusion .

但是F蛋白在获得膜融合活性并使病毒粒子有感染性之前，必需要被细胞内的furin蛋白酶切割成两个二硫键连接的小亚基。

Cleavage of the F protein into two disulfide-linked subunits by a cellular convertase ( furin-like ) is necessary for the low-pH-triggered membrane fusion activity and viral infectivity .

方法从B16黑色素瘤中提取混合蛋白质作为抗原，将其包封在脂质体中并与仙台病毒融合形成的膜融合脂质体，制成疫苗。

METHODS The antigen , mixed protein extracted from B 16 melanoma cell , was encapsulated in membrane fusogenic liposomes prepared by fusing simple liposomes with Sendai virus .

以膜融合脂质体为载体的疫苗既可产生体液免疫又可诱发强烈的CTL反应（P<0.001），并能抑制肿瘤细胞的生长。

However , melanoma vaccine formulated with membrane fusogenic liposome elicited not only systemic immune response but also strong CTL response ( P < 0.001 ), and inhibited the growth of tumor .

泡沫病毒（FV）具有广泛的宿主范围，可以感染从人到鱼几乎所有脊椎动物细胞，可见其包膜蛋白具有极强的膜融合能力。

Foamy viruses have large cellular tropism , which can infect all vertebrates from fish to human being , indicating that Env protein has the high capability of membrane fusion .

荧光显微镜观察结果显示对照组和PDT组没有显著差异，说明PDT不能抑制BIV介导的膜融合。

Fluorescent microscope shows that there is no significant difference between the group of PDT and control , which means PDT could not inhibit the BIV-mediated membrane fusion .

膜融合剂对脂质体及血影膜膜流动性的影响TCS还能作用于红细胞血影膜，改变其脂双层的不对称性。

THE EFFECT OF FUSOGENS ON THE FLUIDITY OF PS LIPOSOMES AND HUMAN ERYTHROCYTE MEMBRANE Besides , TCS could change the asymmetry of phospholipid of erythrocyte membrane , as detected by flow cytometer .

此外，副粘病毒膜融合过程中，融合蛋白的融合肽（FP）、HR3等区域被证明与融合蛋白的构象变化有关。

Fusion protein of Paramyxovirus consists of fusion peptide ( FP ) and heptad repeat 3 ( HR3 ), both of which contribute to membrane fusion .

SNARE蛋白在囊泡运输膜融合阶段起着重要作用，所以在囊泡形成时就必须作为一种特殊的货物蛋白被正确包裹进入囊泡内。

In accordance with their key role in membrane fusion of vesicle transport , the SNARE proteins are always regarded as a special cargo which has to be correctly packed into the vesicles during the budding process .

目的了解副粘病毒融合蛋白（F）分子上的七肽重复序列（HR1、HR2）在特异性膜融合中的作用。

Objective To identify the effects of heptad repeat regions ( HR1 and HR2 ) of fusion protein ( F ) on the specific membrane fusion of paramyxoviruses .

目前，AIV致病机理研究深入，但仍存在一些机制未阐明，其中，血凝素蛋白（HA）是病毒入侵宿主的重要相关因子，并介导病毒吸附与胞膜融合。

At present , AIV-depth study of pathogenesis , it is still not clear , there are some mechanisms , including protein hemagglutinin ( HA ) is a major virus invasion of host-related factors , and mediated virus attachment and membrane fusion .

结论鼠胚胎15d时尿直肠隔与泄殖腔膜融合。胚胎16d肛膜完全破裂，直肠与外界相通。

Conclusions In the normal rats on gestational days 15 , URS fuses with cloacal membrane , and on gestational days 16 anal membrane ruptures and rectum communicate with the anus .

风疹病毒包膜糖蛋白E1和E2介导细胞嗜性，E1在病毒与受体小体膜融合过程中发挥极其重要的作用，这两个蛋白均是体液免疫应答的首要靶蛋白。

The envelope glycoproteins of Rubella virus , E1 and E2 , mediate cell tropism . In particular E1 plays a pivotal role in the fusion of the virus with the endosomal membrane . Both glycoproteins are the prime targets of the humoral immune response .

N-乙基-顺丁烯二酰亚胺敏感性融合蛋白（NSF）为一种ATP酶，是突触传递过程中重要的参与蛋白之一，在突触囊泡与突触前膜融合释放神经递质过程中起着重要的作用。

N-ethylmaleimide-sensitive fusion protein ( NSF ), one kind of ATPase , is considered one of the important proteins in the process of synaptic transmission , which also played an important role in the process of membrane fusion between the synaptic vesicles and presynaptic neurotransmitter release .

30-BL光镜下还具有心肌细胞小灶性变性，电镜下还具有核周水肿，少部分线粒体的嵴或膜融合。

Animals in 30-BL showed small focal degeneration of cardiomyocytes under the light microscope and edema around nuclear as well as small parts fusion of crista or membrane in mitochondrial under the electronic microscope .

由于膜融合过程中形成20S复合体的t-SNARE位于突触前膜，所以我们推测α-SNAP在参与膜融合发生的过程中其细胞内分布有可能发生了变化，如由胞浆分布转移至胞膜。

Since t-SNARE , a key element in the formation of 20S complex , located at presynaptic membrane , we supposed that the translocation of α - SNAP might take place in the process of membrane fusion , for instance , from cytoplasm to cell membrane .

膜融合脂质体为载体的黑色素瘤疫苗的研究

Study on melanoma vaccine using membrane fusogenic liposomes as the vector

禽副粘病毒-2膜融合相关多肽基因的构建与表达

Construction and Expression of Correlative Genes With Membrane Fusion of Avian Paramyxovirus-2

杆状病毒出芽病毒粒子膜融合蛋白的研究进展

Recent Advances on Envelope Fusion Proteins of Baculoviral Budded Viruses

精胺对脂质体及细胞膜融合的作用

The effect of spermine on the fusion of liposomes and human erythrocyte membrane

病毒以胞饮或膜融合形式进入细胞，以出芽方式增殖。

Infectious virons entered cells by endocytosis or membrane fusion and released through a budding process .

泄殖腔构型的变化以及尿直肠隔下降并与泄殖腔膜融合使直肠与膀胱分离。

The fusion of URS with cloacal membrane is essential to the separation of rectum from bladder .