脱髓鞘改变

实验结果表明：普鲁卡因阻滞对脊髓神经元有明显保护作用。（5）大鼠大脑及小脑髓鞘轻度变性，但未见典型脱髓鞘改变。

Mild myelinic degeneration was present in both cerebrum and cerebellum , and no typical demyelination was seen .

上述研究分析表明，脊髓损后由于继发性损害和少突胶质细胞死亡而造成残留脊髓组织内轴突脱髓鞘改变，影响了存留神经纤维的功能发挥。

From above mentioned findings , it is demonstrated that the loss of oligodendrocytes and the secondary injuries cause the demyelination of spared axon in the lesioned spinal cord , which further hampers the neural function of the preserved nerve fibers .

26例患者行腰椎穿刺术，有21例（80·8%）脑脊液呈炎性脱髓鞘改变；脑MR异常和（或）脑脊液异常者29例（72·5%）；

Inflammatory demyelinating changes were found in cerebral spinal fluid in 21 patients ( 80.8 % ) .

大鼠S组TG神经元染包不均，神经纤维脱髓鞘改变，迂曲断裂。

The TG nerve fibers of S group rats were demyelinated , circuity and fractured .

约半数PE患者于发病后2周内并发PE且表现为兴奋型，多数病人脑电图表现为轻～中度广泛性慢波，同步性θ及δ波，头部CT或MRI检查发现脑室水肿和脱髓鞘改变。

About one half patients with PE had nervous-psychotic episode within 2 weeks and were exciting type . There were mild or middle waves and synchronous θ and δ waves in EEG and ventricle edema and demyelination in CT or MRI examination in most cases .

12例突变阳性者检查脑脊液，11例有炎性脱髓鞘改变。

11 of 12 patients who had cerebrospinal fluid examination revealed inflammatory demyelinating changes .

结果光镜下见神经纤维变性萎缩，部分区域呈现脱髓鞘改变，间质中未见炎症细胞浸润；

Results Under light microscope , degenerative atrophy and demyelination were shown in nerve fibers without inflammatory cell infiltration in stroma ;

结论：不同压力作用下受压神经段均发生不同程度节段性脱髓鞘改变；

Conclusion : The degrade of demyelination and calcium , potassium and sodium in compression nerve segments were in right proportion to pressure .

研究表明脊髓损伤后轴突脱髓鞘改变与损伤局部少突胶质细胞死亡有着密切的联系。

The related researches indicate that the demyelination of axons after SCI has a close relationship with the death of oligodendrocytes in the lesion area .

光镜下可见小鼠脑和脊髓组织中有大量的炎性细胞浸润，并伴有明显的白质脱髓鞘改变。

We found there were multiple inflammatory cells in the brain and spinal cords in EAE mice , and the demyelination changes in the white matter were evident .

脊髓损伤不仅造成神经元的丢失，同时还导致少突胶质细胞大量的死亡进而引起神经轴突脱髓鞘改变。

Not only die a lot of neurons after SCI , but a number of oligodendrocytes are also impaired and the demyelination of axons are brought about consequently .

光镜下4例患者腓肠神经表现为不同程度的神经纤维脱髓鞘改变，个别髓鞘纤维增厚，有的只残留一小部分。

Under the light microcopy , the biopsy of sural nerve showed segmental loss of myelin sheaths in different extent , incrassation , regeneration , atrophy and inflammatory cell infiltration .

第21天出现前角细胞数量减少，胶质细胞增生，髓鞘板层状结构断裂，呈脱髓鞘改变，甚至轴索破坏。

At 21st day , the cell number in posterior horn decreased , glial cell proliferated and demyelination occurred characterized by brisement and fragmentation of lamellar texture of myelin sheath even with axis cylinder destruction .

结果系统性红斑狼疮脑病的MRI、CT表现多样：（1）脱髓鞘样改变；

Results The main MRI , CT findings of SLEE were : ( 1 ) demyelination ;

有研究表明，部分CO中毒患者有大脑白质脱髓鞘的病理改变；

Some studies have shown that part patients with CO poisoning are characterized by demyelination in white matter of brain ;

有关研究发现高渗葡萄糖溶液可以导致神经传导速度减慢，神经纤维脱髓鞘等病理改变。

Research found that high permeability glucose solution can cause nerve conduction velocity slower , nerve fiber regeneration etc pathological changes .

目的：从免疫病理学角度探讨痉挛性脑性瘫痪脊神经后根脱髓鞘的病理改变。

AIM : To explore the pathological changes of demyelination of spinal nerve roots in spastic cerebral palsy in terms of immunopathology .

CNS脱髓鞘疾病生物标记物的蛋白质组学研究自体髓核移植可致脊神经节、神经根明显的水肿、炎性反应、脱髓鞘等病理改变。

Proteome Analysis of Biomarkers in the Cerebrospinal Fluid of Central Nervous System Demyelinative Diseases Significant endoneurial edema , inflammation reaction and demyelination can be seen in the DRGs and NRs .