绒毛膜癌

通常有以下几种组织学构成：精原细胞瘤、胚胎癌、畸胎瘤、绒毛膜癌

They often have several histologic components : seminoma , embryonal carcinoma , teratoma , choriocarcinoma .

丝裂霉素C诱发绒毛膜癌患者及正常人淋巴细胞姐妹染色单体互换的研究

Spontaneous and Mitomycin C Induced Sister Chromatid Exchang in Choriocarcinoma Patients and Normal Individuals

端粒酶RNA反义寡核苷酸对人绒毛膜癌裸鼠移植瘤的生长抑制作用

Telomerase RNA antisense oligonucleotides inhibit growth of human choriocarcinoma xenograft in nude mice

它莫西芬对绒毛膜癌细胞株JAR补体调节蛋白表达的影响

Tamoxifen Modulates the Expression of Complement Inhibitory Proteins on Choriocarcinoma Cell Line JAR

马鞭草诱导人绒毛膜癌JAR细胞凋亡作用观察

Observation on the inhibition effect of Verbena Officinalis on human choriocarcinoma jar cells

EV对体外培养的绒毛膜癌JAR细胞有明显抑制作用，且具有特异性，这一作用可能与抑制EGFR的表达有关。

It may relate to inhibition on the expression of EGFR .

目的：探讨马鞭草C部位诱导人绒毛膜癌JAR细胞凋亡的分子机制。

Objective : To investigate the biological effect of part C and the potential mechanisms on Human Choriocarcinoma JAR Cell Line .

结论马鞭草提取液C部位对人绒毛膜癌JAR细胞增殖有明显抑制作用，其作用机制有待进一步探索。

Objective : To investigate the effect of the Part C in Alcohol Extract of Verbena officinalis on Human Choriocarcinoma JAR Cell Line .

结果：Genistein能抑制绒毛膜癌细胞JAR的增殖和诱导凋亡。

Results : Genistein inhibited the proliferation and induced the apoptosis of JAR trophoblast tumor cells .

背景与目的：基因表达谱芯片检测发现葡萄胎和绒毛膜癌存在复制因子C（replicationfactorC，RFC）高表达。

BACKGROUND & OBJECTIVE : High expression of replication factor C ( RFC ) mRNA in hydatidiform mole and choriocarcinoma were detected previously with DNA microarray .

人绒毛膜癌细胞Jar卵泡抑素基因表达的调控

Regulation of Follistatin Messenger Ribonucleic Acid in Human Choriocarcinoma Cell Line Jar by Epidermal Growth Factor and Granulocyte-Macrophage Colony-Stimulating Factor

②方法采用图像分析技术测定100例葡萄胎标本的DNA，RNA含量，同时选择恶性葡萄胎及绒毛膜癌标本20例作对照。

Methods DNA , RNA content was detected by image analysis technique in100 cases of HM , and20 cases of malignant mole and choriocarcinoma were used for comparison .

Genistein对绒毛膜癌细胞增殖、分化、细胞周期和凋亡的影响

Effects of genistein on proliferation , differentiation , cell cycle , and apoptosis of choriocarcinoma cell line JAR

EGFR的表达异常伴随着胎盘滋养层细胞的分化增殖以及功能的改变，本研究目的旨在直接阐述EGFR在滋养层细胞分化发育中的作用，以及与妊高征、绒毛膜癌发病的关系。

An Alteration of EGFR biological activity directly interferes with the differentiated function and proliferation of trophoblast and the fetoplacental development .

目的研究马鞭草C部位对绒毛膜癌JAR细胞绒毛膜促性腺激素（hCG）分泌的影响及其作用机制。

AIM : To study the inhibition effect of Verbena officinals C on secretion of hCG and the mechanism of the human chorionic carcinoma cell line JAR in vitro .

目的探讨经动脉灌注化疗（TAC）在绒毛膜癌的治疗中的优点及其临床应用价值。

Objective To investigate the clinical applying value and virtue of intra-arterial infusion chemotherapy in choriocarcinoma 's treatment .

目的：建立耐甲氨蝶呤（MTX）的人绒毛膜癌细胞株，并检测其生物学特性。

Objective : To establish a methotrexate ( MTX ) - resistant choriocarcinoma cell line and to determine its biologic characteristics .

侵袭性水泡状胎块和绒毛膜癌MMP-2和MMP-9表达明显增强，TIMP-1和TIMP-2多数（+）。

There was obviously increased expression of MMP-2 and MMP-9 in invasive hydatidiform mole and choriocarcinoma but TIMP-1 and TIMP-2 were mostly positive .

目的：研究genistein对绒毛膜癌细胞形态学、增殖、分化、细胞周期和凋亡的影响。

Objective : To study the effects of genistein on morphological changes , proliferation , differentiation , cell cycle and apoptosis of choriocarcinoma JAR cells .

结果显示：正常绒毛0／9，葡萄胎6／20（30%），绒毛膜癌3／4发生p53基因突变。

The results showed that mutations of p53 gene were 0 / 9 in the normal chorionic villi , 6 / 20 ( 30 % ) in hydatidiform mole and 3 / 4 in choriocarcinoma .

目的：妊娠滋养细胞疾病（gestationaltrophoblasticdisease，GTD）是一组来源于胎盘绒毛滋养细胞的疾病，包括葡萄胎、侵蚀性葡萄胎、绒毛膜癌和胎盘部位滋养细胞肿瘤。

Objective : Gestational trophoblastic disease ( GTD ) is a group of diseases from placental trophoblast cells , including hydatidiform mole , invasive mole , choriocarcinoma and placental site trophoblastic tumor .

紫草素诱导人绒毛膜癌JEG-3细胞凋亡机制的研究

Mechanisms of Shikonin-induced Apoptosis in JEG-3 Cells

使用高表达HLA-G的JEG-3细胞系（来源于人绒毛膜癌细胞）进行滋养细胞功能研究。

The HLA-G high expression cell line JEG-3 ( derived from human chorionic carcinoma ) was used for trophoblasts function studies .

在葡萄胎（HM）、侵蚀性葡萄胎（IM）及绒毛膜癌（CC）中E-cad的正常表达率分别为53.3%、31.25%和16.67%；

In HM ( hydatidiform mole ), IM ( invasive mode ) and CC ( choriocarcinoma ), the normal expression rates of E-cad were 53.3 % , 31.25 % and 16.67 % , respectively ;

PSTT的HCG和增殖细胞指数与EPS和绒毛膜癌相比差异均有显著性（P001）。

The differences in the HCG labeling index and proliferative cell index were statistically significant ( P 0 01 ) between PSTT , EPS and choriocarcinoma .

VEGF-B在人绒毛膜癌侵袭转移中作用的研究

Studies of the Expression of VEGF-B in Invasion and Metastasis of Choriocarcinoma

目的探讨核苷酸还原酶小亚基（RRM2）反义寡核苷酸（ASODN）对人绒毛膜癌细胞株JAR细胞体外生长的影响。

Objective To study effect of the antisense oligodeoxynucleotide ( ASODN ) of small subunit of human ribonucleotide reductase ( RRM2 ) mRNA on cell line of human choriocarcinoma in vitro .

结果不同滋养细胞形成的肿瘤其形态结构不同，绒毛膜癌主要表达HCG，上皮样滋养细胞肿瘤主要表达HPL、PLAP。

Results The tumors that were constituted by different trophoblastic cells had differences in conformation and immunohistochemistry stain ; HCG immunostaining were exhibited in the choriocarcinoma while HPL and PLAP in the epithelioid trophoblastic tumor .

对30例绒毛膜癌患者及30例正常妇女进行自发姐妹染色单体互换（SCE）及丝裂霉素C（MMC）诱发SCE率的研究，分析了绒毛膜癌患者及正常人不同年龄组淋巴细胞SCE率的变化。

To investigate the relationship of DNA repair level with age and choriocarcinoma , we studied the frequency of spontaneous sister chromatid exchange ( SCE ) and Mitomycin C ( MMC ) induced SCE ( recovering SCE ) in 30 patients with choriocarcinoma and 30 normal women .

妊娠滋养细胞疾病（GTD）包括葡萄胎、侵蚀性葡萄胎、绒毛膜癌等一系列与妊娠相关的疾病谱，目前为止确切的发病机制仍不清。

Gestational trophoblastic diseases ( GTD ) include the abnormal pregnancy , hydatidiform mole ( HM ), invasive mole , the overtly malignant tumors , choriocarcinoma and placental site trophoblastic tumor . The molecular pathogenesis of GTD remained largely unknown .