石杉碱甲

目的：采用HPLC方法测定石杉碱甲及其制剂的含量。

AIM : To establish HPLC method for the determination of huperzine A in its preparation .

目的：观察石杉碱甲治疗阿尔采末病（AD）的疗效和安全性。

AIM : To evaluate the clinical efficacy and safety of huperzine A in treating Alzheimer diseases ( AD ) .

石杉碱甲片治疗Alzheimer病的随机对照双盲试验

Double-blind Control Treatment of Huperzine-A and Placebo in 28 Patients with Alzheimer Disease

结论：石杉碱甲能有效治疗轻、中度AD患者。

Basic knowledge of analytical reagents & alkalis CONCLUSION : Huperzine A is effective in treating patients with mild and moderate AD.

三种典型的聚合物微球（E、F和H-MS）的体外药物释放表明石杉碱甲的释放没有显著的突释，可缓释药物5～6周。

In vitro drug release from the three kinds of microspheres revealed sustained release of the drug for about 5-6 weeks without significant burst release .

中枢抑制药对毒扁豆碱石杉碱甲LD（50）的影响

Effects of Central Nervous System Depressants on LD_ ( 50 ) of Physostigmine or Huperzine A in Mice

目的与安慰剂双盲对照评估石杉碱甲治疗轻、中度阿尔茨海默病（AD）患者的临床疗效和安全性。

Objective To evaluate the clinical efficacy and safety of huperzine A in treatment of patients with mild to moderate Alzheimer disease ( AD ) .

方法用阳离子敏感性成胶辅料结冷胶，采用pH梯度沉淀法制备了石杉碱甲鼻用原位凝胶。

Methods Using gellan gum , a cation-sensitive gel forming excipient , huperzine A ( Hup A ) nasal in situ gel was prepared by pH gradient precipitation method .

高效液相色谱-质谱-质谱联用法测定Beagle狗血浆中石杉碱甲

Determination of Huperzine A in Beagle Dog Plasma by HPLC / MS / MS Method

石杉碱甲微球对上述3个部位AchE活性的抑制率与血浆浓度之间的关系符合Hill方程，血浓-药效的经时轨迹呈逆时针走向。

The correlation of AchE activity inhibition percentage and plasma concentration conformed to Hill equation . The relationship between pharmacokinetics and pharmacodynamics was counterclockwise hysteresis .

方法：检测石杉碱甲对肝细胞色素P450不同亚型酶活性和表达的影响。

METHODS : The effects of HupA on activities and expressions of cytochrome P-450 ( CYP ) were examined .

结论：益肾补脑片可促进AD患者智能康复，提高AD患者生活质量，其近期疗效可能优于石杉碱甲片。

Conclusion : Yishen Bunao Tablet can promote intelligence recovery and increase quality of life for the patient of AD , and the shot-term therapeutic effect is better than that of huperzine A.

结论茴拉西坦、石杉碱甲均可改善AD病人记忆功能，但其治疗进步是有限的，故必须进行脑功能的康复治疗及良好的护理。

Conclusion Aniracetam and huperzine all could both improve was the memory function of AD patients . But the improvement after treatment was limited So brain function rehabilitation and nursing care are required .

千层塔内生真菌SHB发酵产石杉碱甲条件的研究

Huperzine A Producing Conditions from Endophytic Fungus in SHB Huperzia Serrata

结果ig石杉碱甲0.4mg／kg或他克林40mg／kg或加兰他敏4.0mg／kg均能使小鼠的记忆障碍得到显著的改善。

Results Amnesia in mice can be prevented markedly after huperzine-A 0.4mg / kg , Tacrine 40mg / kg or Galanthamine 4.0mg/kg is administered .

结论：高浓度石杉碱甲能改善乳大鼠脊髓片前角α运动神经元生长，减少其空泡形成及死亡，并降低LDH的释放。

CONCLUSION : High concentration of huperzine A can improve the condition of motor neuron growth , reduce the formation and death of cytoplasmic vacuoles and decrease the release of LDH .

石杉碱甲（Huperzine-A，HA），是一种高效的、可逆的胆碱酯酶抑制剂，可顺利穿透血-脑屏障，并显示出较高的乙酰胆碱酯酶特异性。

Huperzine-A ( HA ), is a potent , reversible acetylcholinesterase inhibitor , which crosses the blood-brain barrier smoothly , and shows high specificity for acetylcholinesterase .

老年痴呆症药物石杉碱甲类似物研究VI.（-）-14-去甲基石杉碱甲的不对称全合成及其乙酰胆碱酯酶抑制活性

Studies on analogues of huperzine A for treatment of senile dementia VI. Asymmetric total synthesis of 14-nor-huperzine A and its inhibitory activity of acetylcholinesterase

对190号菌株发酵产生石杉碱甲进行了HPLC检测，确定其发酵产物中含有石杉碱甲或者其类似物，但由于含量过少，目前没有得到石杉碱甲单体。

Huperzine A content in No. 190 strain fermentation products was tested by HPLC and the results indicated that there were Huperzine A or the analogue of huperzine A but the content was too small to obtain the huperzine A monomer at the moment . 6 .

目的：研究石杉碱甲对遗忘型轻度认知损伤（Mildcognitiveimpairment，MCI）患者内隐和外显记忆功能的影响，为MCI患者的记忆功能康复训练提供理论依据。

AIM : To study the effect of huperzine A on the function of implicit memory and explicit memory in patients with amnesia mild cognitive impairment ( MCI ), and provide theoretic evidence for rehabilitation training of mental function in patients with MCI .

方法：治疗组多梗死性痴呆50例（男性39例，女性11例，年龄66±s8a）服用石杉碱甲片100μg，tid，4wk为一个疗程。

METHODS : Fifty patients with multiple infarction dementia in the treatment group ( M 39 , F 11 , age 66 ± s 8 a ) were treated with huperzine A 100 μ g , po , tid for 4 wk ;

目的：研究石杉碱甲对氧自由基的影响，探讨石杉碱甲抗老年性痴呆的机制。

Objective : To study the anti dementia mechanism of Huperzine A.

物理与化学诱变筛选产石杉碱甲高产菌株的研究

Selection of Huperzine A High-producing Strain by Physical and Chemical Mutation

石杉碱甲治疗血管性痴呆的临床研究

The Clinical Study of Huperzine A in the Treatment of Vascular Dementia

石杉碱甲的大鼠鼻黏膜吸收研究

Study on Nasal Mucosa Absorption of Huperzine A in Rats

石杉碱甲胶囊与片剂治疗良性衰老性遗忘症的双盲对照研究

Huperzine A capsules vs tablets in treating senile amnesia : a double-blind study

高效液相法测定石杉碱甲在大鼠血浆和脑组织中的浓度

Determination of huperzine A in rat plasma and brain tissue by HPLC method

石杉碱甲缓释微球的制备及其在大鼠体内的药动学与药效学研究

Preparation of huperzine-A-loaded microspheres and studies on its pharmacokinetics and pharmacodynamics in rats

石杉碱甲治疗重症肌无力症128例

128 cases of myasthenia gravis treated with huperzine A

石杉碱甲对老年患者腹部手术后认知功能障碍的双盲研究

The Effect of Huperzine on Cognitive Dysfunction After Abdomenal Surgery in elder Patients