氯喹

此前，在周五发表的一项大型观察性研究中发现，使用氯喹和羟氯喹的新冠病人患心脏病和死亡的风险会增加，因此做出这一决定。

The move follows findings from a large observational study , published Friday , that found increased risk of heart problems and death in COVID-19 patients who used chloroquine and hydroxychloroquine .

对照药氯喹对疟原虫DNA含量和溶酶体pH值也有相同影响。

Chloroquine had the same effects on DNA and lysosome pH of malarial parasites .

世界卫生组织官员估计暂停会持续一至两周，因为试验数据安全监测委员会要参考从SOLIDARITY临床试验和其他进行中的研究中所收集的信息，从而确定继续使用羟氯喹是否安全。

WHO officials estimated the pause would last a week or two as the trial 's data safety monitoring board considers information already collected from the Solidarity trial and other ongoing studies to determine whether it 's safe to continue with hydroxychloroquine .

这项研究是随机试验，从三月份开始在至少17个国家召集了3500名患者来研究4种药物，其中就包括羟氯喹。

The study , a randomized trial , has enrolled 3500 patients in at least 17 countries since March to study four medicines , including hydroxychloroquine .

周一，世界卫生组织官员宣布，审查安全数据期间，在对新冠病毒疗法的全球研究中暂停使用羟氯喹。

The World Health Organization is pausing the use of hydroxychloroquine in its global study of COVID-19 treatments amid a review of safety data , officials announced Monday .

伯氏疟原虫氯喹抗性株和敏感株基因组DNA比较研究

Comparative Study on Genomic DNA of Malaria Parasite : Chloroquine-resistant and Chloroquine-sensitive Strains of Plasmodium berghei

HPLC法测定复方地巴唑氢氯噻嗪胶囊中硫酸胍生和磷酸氯喹的含量半乳糖基胍及糖基异脲衍生物的合成

Determination of Guanoxan Sulfate and Chloroquine Phosphate Hydrochloride in Compound Dibazol and Hydrochlorothiazide Capsules by HPLC

13种抗疟药复方对伯氏疟原虫抗氯喹‘NS’株的疗效

Therapeutic effects of 13 combinations of antimalarials against Plasmodium berghei " ns " strain

氯喹抑制LPS和CPGDNA诱导人外周血单个核细胞释放促炎细胞因子的研究

Study of chloroquine on pro-inflammatory cytokines released by human peripheral blood mononuclear cells induced by LPS and CpG DNA

Peyton的研究组把一种“逆转剂”（reversalagents）附着在氯喹分子上，使之产生一种单一混合物分子。

Peyton 's team attached one of these'reversal agents'to chloroquine to produce a single hybrid molecule .

海南省间日疟原虫CSP基因型虫株对氯喹敏感性和复发特征的初探

The sensitivity of Plasmodium vivax genotype strain of circumsporozoite protein to chloroquine and the recrudescence

并观察溶酶体抑制剂氯喹和聚乙烯亚胺（PEI）对其转染效率的影响。

The influence of chloroquine and polyethyleneimine was observed .

方法：大耳白兔随机分为对照组、ET致伤组、ET致伤+氯喹干预组。

Methods : Rabbits were randomly assigned to three groups : control group , ET group , and ET + chloroquine group .

利用压电石英阻抗技术和电容传感技术对DNA与磷酸氯喹的相互作用研究的结果，均表明该反应可描述为两步串联反应。

The results of quartz crystal impedance ( QCI ) and capacitive sensing method indicate that the combination of DNA with chloroquine can be described as two stages series reaction model .

彗星实验在50010002000mg/（kg.bw）浓度下，二氯喹啉酸对小鼠骨髓细胞的DNA损伤与阴性对照组比较差异有统计学意义（P<0.01），且呈剂量-效应关系。

Compared with the control group , the DNA migration increased significantly at the different three test doses of Erythroblast cells ( P < 0.01 ) and exhibited a significant dose-effect relationship .

结论微波配合氯喹治疗OLP是有效的方法。

Conclusion Microwave combined with CQ is an effective method to treat OLP .

[结论]氯喹在感染了伯氏疟原虫RC株鼠体内的消除速度显著快于正常鼠及感染N株鼠。

[ Conclusion ] Elimination of chloroquine in the mice infected with the RC strain of P. berghei speed up significantly comparing with the mice infected with the N strain .

目的：了解伯氏疟原虫氯喹敏感株（N）和抗性株（RC）红内期虫体在抗药性、致病力和诱导免疫应答方面差异的形态学基础。

Objective : To understand the morphologic foundation for differences in drug-resistance , virulence and immunity between chloroquine-sensitive ( N ) and chloroquine-resistant ( RC ) strains of Plasmodium berghei .

目的观察氯喹对脂多糖（LPS）和CPGDNA诱导人外周血单个核细胞释放促炎细胞因子的抑制作用。

Objective To observe the inhibitory effect of chloroquine on pro-inflammatory cytokines released by human peripheral blood mononuclear cells ( hPBMC ) induced by LPS and CpG DNA .

氯喹对戊四氮致痫大鼠GFAP、PCNA及cyClinD1变化的影响

Effects of chloroquine on GFAP , PCNA and Cyclin D1 expressions in hippocampal astrocytes and cerebral cortex of rats with epilepsy induced by pentylenetetrazole

[方法]应用反相高效液相色谱法分别测定正常小鼠、感染伯氏疟原虫N株和RC株小鼠血浆中的氯喹浓度，采用3P87药物动力学分析软件对数据进行分析，从而获得有关药物动力学参数。

[ Methods ] The concentrations of chloroquine in the plasma of normal mice and the mice infected with the N or the RC strains of P. berghei were analyzed by reverse phase HPLC .

氯喹可抑制PLA2激活和氧化损伤，对ET所致的兔早期ALI具有一定的保护作用。

Chloroquine can inhibit PLA_ 2 activation and oxidative injury , which can alleviate the degree of ET-induced early ALI in rabbits to some extent .

初步实验显示氯喹中毒首先促进肌肉细胞中APP与tau蛋白的表达，在第4周达到高峰，然后表达逐渐减少，在第10周转为明显抑制作用。

Preliminary experiments indicate that the expressions of both APP and tau in rat muscle were first increased and then decreased by chronic intoxication with chloroquine .

目的探讨羟氯喹治疗对痛风患者血尿酸（UA）和血脂的影响及其安全性。

Objective To investigate the effect and safety of hydroxychloroquine ( HCQ ) on serum uric acid ( UA ) in gout arthritis .

与模型组相比，氯喹干预组和PDTC预防组上述改变得以逆转，肺损伤程度明显减轻（P0.05）。

These changes were inverted in Chloroquine treatment group and PDTC prevention group rats , the degree of lung injury was markedly relieved ( p0.05 ) .

胰岛素和氯喹对大鼠肝细胞EIG的影响可能是通过影响IDE基因转录来实现。

Effects of insulin and chloroquine on EIG may influence the transcription of EIP in the hepatocytes of rat .

方法：采用流式细胞术（FCM）分析了本芴醇和氯喹对鼠伯氏疟原虫K173株DNA含量及溶酶体pH值的影响。

Methods : Flow cytometry ( FCM ) was used to analyze the effects of B and chloroquine ( CQ ) on DNA content of Plasmodium berghei and pH value of the lysosome of malarial parasites .

观察和比较青霉胺、氨苯砜、氯喹、四环素、美满霉素和灭滴灵对PMN产生ROS和非细胞体系的和·OH的影响。

We investigated the effects of penicillamine , chloroquine , dapsone , metronidazole , tetracycline and minocycline on ROS generated by PMNs and O ,· OH generated in the cell-free system .

结果提示，青霉胺、氯喹、美满霉素、灭滴灵、氨苯砜和四环素具有抑制或清除PMN产生的ROS；

The results showed that penicillamine , chloroquine , minocycline , dapsone , tetracycline and metronidazole had an effect of inhibiting or scavenging ROS generated in PMNs ;

目的：探讨氯喹对烟雾吸入伤大鼠肺细胞膜ATP酶活性及丙二醛含量的影响。

OBJECTIVE : To explore the influences of chloroquine on the activities of adenosinetriphosphatases ( ATPases ) and the content of malondialdehyde ( MDA ) on rats model of smoke inhalation injury .