氟喹诺酮

离子对HPLC同时测定5种氟喹诺酮类药物

Separation and Determination of Five Fluoroquinolone Antibiotics by Ion Pair-HPLC

恩诺沙星（enrofloxacin，ENR）是动物专用的氟喹诺酮类药物，广泛用于动物疾病的治疗和预防。

Enrofloxacin ( ENR ), a fluoroquinolone , is specific for treatment and prevention of animal disease .

HPLC法测定猪组织中氟喹诺酮类兽药残留的方法研究

The Research on Multiresidue Determination of Fluoroquinolones in Pig Tissue by HPLC

结论：对氟喹诺酮类药物高度耐药的大肠埃希菌的DNA旋转酶A亚单位存在着基因点突变。

Conclusion : Mutations of gyr ( ase ) A gene subunit existed in fluoroquinolone resistant Escherichia coli .

HPLC法测定鳗鱼中多种氟喹诺酮

Determination of multi-residue for quinolones in eel by HPLC

DNA促旋酶和拓扑异构酶Ⅳ的改变是大肠埃希菌对氟喹诺酮类耐药的主要机制。

The alteration of DNA gyrase and DNA topoisomerase IV is the main mechanism of resistance to fluoroquinolones in E. coli .

分别考察了缓冲溶液pH值，浓度，电压，温度等因素对8种氟喹诺酮药物分离的影响。

Study on the effects of pH , concentration of buffer , voltage and temperature to the separation of the fluoroquinolones .

norA基因mRNA表达水平与表皮葡萄球菌氟喹诺酮耐药性的关系

The Relationship between mRNA Expression Levels of norA Gene in Staphylococcus epidermidis and Fluoquinolones Resistance

氟喹诺酮类药物主要通过抑制细菌的DNA旋转酶，使细菌不能进行正常DNA复制和分裂，从而产生快速杀菌作用。

Fluoroquinolones , primarily by inhibiting bacterial DNA gyrase , so that bacteria can not engage in normal DNA replication and division , resulting in rapid bactericidal effect .

氟喹诺酮类药物与其所致QT间期延长

Fluoroquinolones and the lengthening of QT Interval

细菌产ESBLs的自动监测及其对氟喹诺酮类药物耐药性的变迁

Automatic detection of ESBLs - producing bacteria and the drug resistance change to quinolones

MRSA对环丙沙星的耐药率高达794%，且对其他氟喹诺酮交叉耐药。

The resistance rate of MRSA to ciprofloxacin was 79.4 % and cross resistance existed .

方法临床标本分离的80株淋病流行株，采用琼脂稀释法测定淋球菌对8种氟喹诺酮药物的最小抑菌浓度（MIC）及交叉耐药情况。

Methods : The susceptibilities of 80 gonococcal epidemic strains to 8 fluoroquinolones were detected by agar dilution methods .

结果：F检验表明，上述各因素及各因素的交互作用对活性炭吸附氟喹诺酮类药物有显著性或非常显著性的影响。

RESULTS : The F test showed that adsorption of three fluoroquinolones on activated carbon was influenced markedly or very markedly by the factors and the combined action of them .

氟喹诺酮和硝基甲烷的SNAr反应

S_NAr Reaction of Some Fluoroquinolone Intermediates with Nitromethane

目的：研究本院近3年大肠艾希氏菌、肺炎克雷伯菌产ESBLs的自动快速监测与检出率及其对氟喹诺酮类药物耐药性的变迁。

Objective To research automatic detection of ESBLs - producing Escherichia coli , Klebsiella pneumonia and the drug resistance change to quinolones .

大肠埃希菌对氟喹诺酮类药物存在交叉耐药性，且产ESBLs的大肠埃希菌对氟喹诺酮类药物存在相关耐药。

The cross-resistance of E. coli to fluoroquinolones exists and the associated resistance of ESBLs-producing E. coli to fluoroquinolones exists . 3 .

为了检测氟喹诺酮类药物与甲氧苄氨嘧啶（TMP）联合用药产生的作用，作者进行了环丙沙星与TMP联用的体外抑菌试验。

The effects of the combination of ciprofloxacin and trimethoprim ( TMP ) in vitro against some main veterinary pathogenic bacteria were reported .

结论常规剂量的氟喹诺酮类抗菌药物不宜单独用于经验性治疗ECO感染，特别是对泌尿道感染的中老年男性患者。

CONCLUSIONS Routine dosage of fluoroquinolones is not fit for empiric monotherapy for ECO infection , especially for middle-aged and old male patients with urinary tract infection .

方法：将菌液制成0.5麦氏比浊标准，采用肉汤稀释法测定细菌对TMP和氟喹诺酮类药物的MIC；

Methods : Bacterial fluid of 0.5 McFarland standard and broth dilution method was used to test its MIC to TMP and fluoroquinolones medicines ;

目的：研究检测解脲脲原体（Uu）临床株对氟喹诺酮类药物的敏感性，为临床治疗提供参考依据。

Objective : To determine the susceptibility of clinical Ureaplasma urealyticum ( Uu ) isolates to fluoroquinolones and provide experimental data for clinical therapy .

产ESBLs菌检出率为12%，对三、四代头孢菌素及氟喹诺酮类耐药比例较高。

Bacteria producing extended-spectrum beta-lactamase ( ESBLs ) accounted for 12 % which had high resistance to third and forth generation cephalosporins and fluoroquinolones .

对MDR-TB的治疗主要依靠二线抗结核药物，主要有氨基糖苷类、多肽类、氟喹诺酮类等。

The treatment of MDR-TB largely relies on the second line anti-TB drugs , including aminoglycosides , polypeptides , thioamides and fluoroquinolones .

以上结果提示：氟喹诺酮药物的杀菌作用与其抑制细菌DNA合成有关，且须以RNA和蛋白质不断合成为前提条件；

These results suggested that the bactericidal actions of NFX , ENX , and PFX are all interrelated with their inhibitory effects on bacterial DNA synthesis , and continuous RNA and protein synthesis are prequisites for the bactericidal action .

为了分别测定血样和尿样中2种氟喹诺酮类抗生素，本文建立了两种简便的HPLC-UV法和一种专属、快速的LC／MS／MS法，所建方法已被成功地应用于药物动力学研究。

Two convenient HPLC-UV method and a specific and rapid LC / MS / MS methods were developed to determine two quinolones antibacterial agent levels in human plasma and urine , respectively .

氟喹诺酮类药物对肠道致病菌的体外耐药性及交叉耐药食源性革兰氏阴性肠道病原菌PFGE分型和大肠杆菌耐药性研究

Resistance and cross-resistance of intestinal bacteria to fluoroquinolones Study on PFGE Subtyping of Gram Nagetive Foodborne Pathogen and Antibiotic Resistance of E.Coli

PCR扩增及DNA序列分析发现，临床株LC1的marOR基因存在3处突变。结论对氟喹诺酮类耐药的临床分离大肠杆菌中存在Mar耐药机制。

Sequence analysis showed three mutant spots in mar OR of clinical strain LC 1 . Conclusion There does exist mar mechanism in clinical isolated Escherichia coli resistant to fluoroquinolone .

氧氟沙星（ofloxacin，OFL）属于氟喹诺酮类药物，具有较强的抗革兰氏阴性和阳性细菌的作用。

Ofloxacin ( OFL ) belongs to the family of Fluoroquinolones and has a spectrum of activity against gram-negative and gram-positive bacteria organisms .

葡萄球菌多重耐药转运蛋白NorA介导的氟喹诺酮耐药性研究猪链球菌对氟喹诺酮类药物耐药性与耐药基因的研究

Resistance Against Fluoroquinolones Mediated by Multidrug Resistance Efflux Protein NorA in Staphylococcus ; Study on the Relationship between Fluoroquinolone Sensitivity and Gene Mutations of Streptococcus Suis

CCCP等能量抑制剂可加强细菌对氟喹诺酮类药物的摄取量。

The energy resistance inhibiter , such as CCCP , can intensify bacterial ingestion to fluoroquinolone drugs .