槟榔碱

槟榔碱的代谢酶在SD大鼠体内广泛存在，尤其以肝脏，血液丰富。

Arecoline metabolic enzymes in SD rats was widespread , especially in the liver and blood .

离子对RP-HPLC槟榔碱测定方法的建立与应用

Establishment and Application of Ion-pair RP-HPLC Method in Arecoline Determination

方法：采用MTT法检测槟榔碱干预后的EC存活率。

METHODS : Cell survival rate was detected by MTT assay .

槟榔碱代谢酶分布于SD大鼠肝细胞内各亚细胞组分。

Arecoline metabolic enzymes distributed in the subcellular fractions of SD rat liver cells subcellular fractions . 3 .

结论：槟榔碱可诱导血管内皮细胞凋亡，Caspase-3可能参与了这一细胞凋亡过程的调控。

Conclusion : Arecoline may induce the apoptosis of HUVECs and caspase-3 takes part in the control of apoptotic process .

槟榔碱呈剂量依赖性增加KCCOX-2蛋白表达，不同浓度槟榔碱组均高于空白对照组（P0.05）。

The COX-2 protein expression of KC was increased by arecoline in a dose-dependent manner and was elevated significantly comparing to control group ( P 0.05 ) .

M受体拮抗剂阿托品2mg／kg可对抗槟榔碱200mg／kg（ip）提高大脑皮层和海马中肌醇含量的作用；

The increase of myo inositol in cerebral cortex and hippocampus by arecoline 200 mg / kg was prevented by atropine 2.0 mg / kg .

目的：初步探讨凋亡核心蛋白酶&Caspase-3在槟榔碱（Arecoline）诱导血管内皮细胞（Endothelialcells，EC）凋亡中的作用。

Objective : The purpose of the study is to investigate the mechanism of the change of caspase-3 activity on the arecoline-induced apoptosis in endothelial cells ( EC ) .

慢性实验中，给槟榔碱2，5，10mg／kg（sc）每日2次14d后，在10mg／kg剂量下可显著地提高大脑皮层中肌醇含量；

In the chronic experiment , rats were treated with arecoline 2 , 5 , 10 mg / kg ( sc ) twice a day for 14 days .

急性实验中，经M受体激动剂槟榔碱50100200mg／kg（ip）30min后，在100和200mg／kg剂量下可显著地提高大鼠大脑皮层和海马中肌醇含量，但不影响纹状体中肌醇含量；

In the acute experiment , myo inositol levels were increased in rat cerebral cortex and hippocampus but not in striatum by arecoline 100 and 200 mg / kg ip .

烟碱2mg／kg与槟榔碱5mg／kg之间存在协同作用，进一步提高大脑皮层中肌醇含量，烟碱的这一作用可为美加明1mg／kg所对抗。

The synergism of increase in myo inositol level was also observed between nicotine 2 mg / kg and arecoline 5 mg / kg . This effect of nicotine could be prevented by mecamylamine 1.0 mg / kg .

槟榔碱（2·0mg·kg-1）可增强单次给予吗啡所诱导的小鼠的高活动性（P<0·05）；

Co-administration of AREC ( 2.0 mg · kg ~ - 1 ) heightened the hyperactivity induced by a single administration of Mor in mice ( P < 0.05 );

结果：用原头节感染的6只家犬，在感染后35d和45d用槟榔碱驱虫，每只犬驱出成虫14780至135900条。

I. RESULTS : Six dogs were heavily infected , the worm burden were 14 780 to 135 900 at days 35 and 45 p. i.

目的探讨环氧合酶-2（COX-2）在口腔黏膜下纤维性变（OSF）癌变组织中的表达，观察槟榔碱对人口腔角质形成细胞（KC）COX-2表达的影响。

Objective To investigate the expression of cyclooxygenase-2 ( COX-2 ) in carcinogenesis lesions of oral submucous fibrosis ( OSF ), and the effects of arecoline on the expression of COX-2 in cultured human oral keratinocytes ( KC ) .

槟榔碱与灭螺药物合用的增效作用研究

Studies on synergic effect of arecoline in combination with snail-killing drugs

毛细管电泳法分析槟榔中槟榔碱和槟榔次碱

Separation and Quantitative Determination of Arecoline and Arecaidine by Capillary Electrophoresis

槟榔碱改善2型糖尿病大鼠糖、脂代谢紊乱

Arecoline improved glucose and lipid metabolism in type 2 diabetic rats

烟碱和槟榔碱对大鼠颌下腺肌醇含量的影响

Effects of nicotine and arecoline on inositol levels of rat submandibular glands

槟榔碱诱导体外培养的血管内皮细胞凋亡

Experimental study on the apoptosis of vascular endothelial cells induced by arecoline

出生前暴露于槟榔碱（槟榔果中的生物碱）及其出生转归

Prenatal exposure to arecoline ( areca nut alkaloid ) and birth outcomes

槟榔碱对小鼠小肠运动的影响

Effect of Arecoline on movement of small intestine in mice

槟榔碱对口腔颊黏膜成纤维细胞和血管内皮细胞增殖活性的影响

Effects of arecoline on proliferation of fibroblast and endothelial cell

槟榔碱对血管内皮细胞分泌NO的影响

Effects of arecoline on the levels of NO expression of endothelial cell

槟榔预处理方式对槟榔碱提取率的影响

Study of the impact of pretreatment on arecoline extraction rate

槟榔碱对细胞增殖、凋亡和炎症反应影响的研究进展

Effects of Arecoline on Proliferation , Apoptosis and Inflammation Response of Cells

槟榔碱及其片剂的制备与质量标准的制定

Preparation and Quality Standard Making of Arecoline and Its Tablets

2大孔树脂对槟榔碱的富集纯化研究本文探讨了大孔吸附树脂法对槟榔碱分离的影响。

Discussed by macroporous adsorption resin separation effect of arecoline .

槟榔碱对大鼠脑肌醇含量的影响以及与烟碱的相互作用

Effects of arecoline on myo inositol level of rat brain and nicotine modulation

目的研究槟榔碱抗高血脂诱发大鼠动脉粥样硬化作用的分子机制。

AIM To investigate the anti-atherosclerosis mechanisms of arecoline .

烟碱对氧化震颤素和槟榔碱流涎作用的调节

Modulatory effects of nicotine on oxotremorine - and arecoline-induced