普罗帕酮

高血压并发阵发性心房颤动时P波离散度的变化及普罗帕酮的治疗效果

A clinical analysis on the change of P wave dispersion and the therapeutic effect of propafenone in essential hypertensive patients with paroxysmal auricular fibrillation

胺碘酮美西律普罗帕酮对QT离散度影响的临床观察

Clinical Study of Amiodarone , Mexiletine and Propafenone on QT Dispersion

目的：探讨静脉注射盐酸普罗帕酮注射液对永久人工心脏起搏器心房、心室起搏阈值及心内电信号P波、R波振幅的影响。

Objective : To observe the effects of propafenone hydrochloride injection on permanent heart pacing threshold and endocardial electrical signal amplitude .

胺碘酮也可降低IDA及SR，但与血药浓度无关。结论普罗帕酮和胺碘酮均可降低安置起搏器病人的心脏感知功能。

Conclusion Propafenone and amiodarone reduce cardiac sensing function of patients with pacemaker .

目的：观察和比较静脉注射胺碘酮、普罗帕酮治疗宽QRS波群心动过速的即时疗效和安全性。

Objective : To compare the efficacy and safety of intravenous amiodarone and propafenone for broad QRS tachycardia .

结论盐酸普罗帕酮注射液在避光注射器中较稳定，建议ICU使用避光注射器，并在8h内用完。

Conclusion It 's better to use propafenone hydrochloride with the photophobic syringe in 8 h in ICU .

普罗帕酮组总有效率87.5%，平均起效时间（8.1±4.6）min。

The average time to onset of action was ( 4.9 ± 3.3 ) min for GFA hydrochloride injection group and ( 8.1 ± 4.6 ) min for propafenone group .

应用普罗帕酮激发试验对Brugada综合征七例患者的诊断价值

The diagnostic value of propafenone challenge testing in seven patients with Brugada syndrome

探索普罗帕酮试验在Brugada综合征中的作用及安全性。

To identify the diagnostic impact and safety of the propafenone in Brugada syndrome .

目的比较普罗帕酮和美托洛尔治疗病毒性心肌炎（VM）所致室上性和室性期前收缩的疗效和不良反应。

Objective To compare the efficacy and side effects of propafenone and metoprolol therapies on ventricular or supraventricular extrasystole induced by viral myocarditis ( VM ) .

方法对30例患者行食管心房调搏检查，测定三个不同心房BCL下心房、房室传导系统功能和有效不应期，以及静脉注射普罗帕酮后起搏周长对不应期的影响。

Methods Refractory periods of atrioventricular conduction system were determinated at three cycle lengths in 30 patients with supraventricular tachycardiac history by transesophageal atrial pacing .

目的评价应用普罗帕酮激发试验诊断Brugada综合征（BS）的有效性和特异性。

Objective To evaluate the effectiveness and specificity of propafenone challenge testing in the diagnosis of Brugada syndrome ( BS ) .

结论ATRA联合As2O3治疗APL患者不仅能获得好的疗效，而且能缩短达CR的时间。结论胺碘酮和普罗帕酮对阵发性房颤均有较高的转复率，但转复时间普罗帕酮短于胺碘酮。

Conclusion The As 2O 3 and ATRA in the treatment of APL can obtain a higher CR rate and a shorter duration for achieving CR.

结果表明：普罗帕酮灌流浓度为1×10－6，6×10－6M时，钠峰值电流分别下降35.0%、52.8%，P均＜0.01；

The results demonstrated : 1 × 10 - 6 , 6 × 10 - 6 M propafenone reduced I Na by 35 0 % and 52.8 % respectively ( P < 0.01 ) .

结论普罗帕酮激发试验可有效、特异地用于诊断Brugada综合征。

Conclusion The data suggested that propafenone challenge testing was effective and specific in the diagnosis of concealed Brugada syndrome .

目的：研究普罗帕酮（PPF）经人肝CYP3A4代谢的立体选择性。

AIM : To investigate the stereoselective metabolism of propafenone ( PPF ) by human liver CYP3A4 .

对照组35例，口服硝酸异山梨酯10mg加普罗帕酮（心律平）150mg，每日3次，总疗程4周。

The pts in control group took Isosorbide Dinitrate 10 mg with propafenone 150 mg three times a day for 4 weeks .

普罗帕酮最严重的不良反应为低血压（2.86%，1/35）及长间歇（RR间期>2.0s，11.43%，4/35）。

Hypotension ( 2.86 % ) and heart pause ( RR interval > 2.0 s , 11.43 % ) were the most serious adverse events in patients who received propafenone .

两组比较4h内普罗帕酮组房颤转复率明显高于毛花甙C组（P0.05），4h内的平均转复时间亦有明显差异（P0.01）。

In the first 4 hours , the success rate of reversing AF and average reversal time was significantly higher in the propafenone group than in the lanatoside C group ( P 0.05 and P 0.01 ) .

方法本文分别采用普罗帕酮和维拉帕米治疗PSVT患者，并对两个药物进行疗效对比。

Methods In this paper , using propafenone and verapamil to treat paroxysmal supraventricular tachycardia patients , and comparing their clinical efficacy .

方法观察盐酸普罗帕酮注射液在常规和避光两种注射器中0h2、h4、h6、h8、h1、2h2、4h的pH值和含量变化情况。

Methods Injection of propafenone hydrochloride was put in routine and photophobic syringes and the variation of content and pH value were observed during 24h of all the syringes .

普罗帕酮24h内急诊转复率62.2%，心室率控制满意，两者疗效比较差异有显著性（P<0.01）；

Results An emergency cardioversion ratio was 28.1 % with lanatoside within 24 h with a satisfactory control of ventricular rate , as compared with that of 62.2 % with propafenone ( P < 0.01 ) with unsatisfactory control of ventricular rate .

进口普罗帕酮组治疗前后P-R间期经t检验，延长有统计学意义P<0.05），对ECG的其他指标在治疗前后均无统计学意义（P>0.05）；

P-R interval before and after treatment with imported propafenone was significant ( P < 0.05 ), and electrocardiogram ( ECG ) indexes else between before treatment and after treatment of imported propafenone were insignificant statistically ( P > 0.05 ) .

目的：研究高蛋白、高脂肪、高碳水化合物饮食大鼠的普罗帕酮（PPF）药物动力学，以了解饮食因素对PPF氧化代谢的影响。

AIM : To study the effect of high protein , high fat , and high carbohydrate diet on propafenone metabolism in rats and determine and whether dietary factors affect propafenone oxidative metabolism .

目的报道10例疑诊Brugada综合征（BS）患者的普罗帕酮激发试验的结果，并探讨高位右侧胸前导联心电图在普罗帕酮激发试验中的价值。

Objective To report the result of propafenone challenge test in 10 patients who were suspected of Brugada syndrome ( BS ) , and evaluate the effectiveness of right precordial leads at higher intercostals space position to diagnose Brugada syndrome .

结果表明，Iso能使普罗帕酮和莫雷西嗪的抗RSVT总有效率分别降低66.7%～80.0%和20.0%，该效应能被Met所抵消。

The results showed that total effective rates of propafenone and moricizine on RSVT had a 66.7 % ~ 80 % and 20 % , respectively , of reduction , which could be cancelled out by Met , during Iso venoclysis as compared with basic state .

结论中心复合设计优化处方预测性良好，制得盐酸普罗帕酮缓释微丸符合实验设计要求。

The pellets comply with the requirements of the experiment design .

普罗帕酮对映体对麻醉兔希氏束电图的影响

Effects of propafenone enantiomers on His bundle electrograms in anesthetized rabbits

目的：建立普罗帕酮中毒快速检验方法。

OBJECTIVE : To develop a rapid examination for propafenone poisoning .

普罗帕酮急诊转复阵发性室上性心动过速120例临床分析

Clinic Analysis on 120 Cases of Propafenone on Paroxysmal Supraventricular Tachycardia