微丸

目的制备维生素C微丸，并评价其稳定性。

Objective To prepare vitamin C pellets and evaluate their stabilities .

复方丹参pH依赖型延迟释药微丸在家犬体内的药效动力学

Pharmacodynamics of compound danshen pH-dependent delayed release pellets in dogs

复方维生素B6缓释微丸胶囊的制备及质量控制

Preparation of Compound Vitamin B6 Sustained-release Capsules and their Quality Control

维生素C微丸缓释胶囊的体外释放特征

In vitro release characteristics of capsules on vitamin C sustained release pellets

维生素C包衣微丸的制备及稳定性研究

Preparations and stabilities of vitamin C pellets

HPLC法测定茶碱脉冲控释微丸胶囊中主药的含量

Determination of Theophylline in Pulsatile Controlled-release Pellets Capsule of Theophylline by HPLC

在含生药量近似的情况下，上述药理作用微丸与蜜丸间无显著差异（P＞0.05）。

Under the condition that two preparations contain approximate crude drug dose their pharmacological actions showed no significant difference ( p > 0 . 05 ) .

目的制备麝香保心pH依赖型梯度释药微丸并进行体内外考察。

AIM To prepare heart protecting musk pH dependent gradient release pellets and investigate the drug release in vitro and in vivo .

结果制备了复方丹参pH依赖型延迟释药微丸，体外溶出曲线呈pH依赖特征。

Results The compound danshen pH-dependent delayed release pellets were prepared with the characteristics of pH dependent delayed release profile in vitro .

RP-HPLC测定大豆异黄酮缓释微丸胶囊的含量

Determination of Genistein in Soybean Isoflavone Sustained-release Pellet Capsules by RP-HPLC

结果：缓释微丸的体外药物释放呈pH非依赖型释放特征，符合一级动力学方程。

RESULTS The release of DIP from the pellets was pH independent and the dissolution profiles of it followed the first grade model kinetics .

结果本研究制备的口服脉冲释药微丸在人体内实现了3h时滞后的脉冲释药。

Results The pulsed release pellets can achieve the lag time of 3h in vivo .

盐酸青藤碱控释微丸在Beagle犬体内药物动力学研究

Pharmacokinetics of Sinomenine Hydrochloride Controlled-release Pellets in Beagle Dogs

目的：制备双嘧达莫pH非依赖型缓释微丸，使药物释放不受胃肠道pH值变化及个体差异的影响。

OBJECTIVE To prepare pH independent sustained release pellets of dipyridamole ( DIP ), the drug release not being influenced by pH of the gastrointestinal tract and by individual difference .

目的评价pH依赖型盐酸二甲双胍缓释微丸（T1）和非pH依赖型盐酸二甲双胍缓释微丸（T2）在健康人体内的药代动力学和相对生物利用度。

Objective To investigate the pharmacokinetics and relative bioavailability of the pH-dependent ( T1 ) and non-pH-dependent ( T2 ) sustained-release metformin hydrochloride pellets .

pH梯度释放实验结果表明，所研制的包衣微丸人工胃液中2h药物仅释放4.98%；

The releasing test showed that the drug was released only 4.89 % in the simulated gastric fluid ( pH 1.2 ) in 2 h ;

以HPLC方法测定人体内血药浓度，以普通制剂为对照，研究了盐酸昂丹司琼缓释微丸的家犬体内相对生物利用度和药代动力学。

A reversed-phase HPLC method was established for determination of OND drug plasma concentration . Pharmacokinetics of ondansetron sustained-release capsule and conventional capsule was studied in three dogs .

结果：乳糖代替HPMC包衣的微丸释药后衣膜也出现破裂；

Results : Film rupture occurred in pellets with lactose instead of HPMC in the coating formulation .

目的研究制备人参总皂苷磷脂复合物（GSP）及其包衣微丸的方法。

OBJECTIVE To study the preparation methods for ginsenoside phytosome ( GSP ) and their pellets coated with HPMC .

本文选择具有镇静安眠止痛作用的豆腐果素为模型药物，根据其理化性质和胃肠道吸收特点，设计研制12h缓释微丸。

According to the physicochemical properties and absorption characteristic of Helicidum in rats , its 12h sustained-release pellets were developed in this paper .

采用HPLC法进行微丸中药物的含量测定，比色法对释放度进行测定，建立了高效液相色谱紫外检测法测定家犬体内血药浓度的方法。

HPLC was utilized to determine the Roxithromycin content in pellets , colorimetry for assaying release of Roxithromycin sustained release pellets . The HPLC ultraviolet method was established to monitor the plasma concentration in dogs .

目的制备双氯芬酸钠脉冲控释微丸（DSPRP）并考察体内外释药特性。

Aim To investigate the preparation of diclofenac sodium pulsatile release pellets ( DS PRP ), the release in vitro and the pharmacokinetics of the drug .

结论用两种黏合剂制备的缓释微丸，体外释放均可达到10h以上。

CONCLUSION The in vitro dissolution tests of ketoprofen sustained release pellets can sustained release over 10 h with the two meltable binder .

采用EudragitNE30D／L30D-55水分散体混合作为包衣材料，对微丸包衣。

The pellets were coated with a blend of Eudragit NE30D / L30D-55 as well .

采用乙基纤维素水分散体（Aquacoat和Surelease）为包衣材料，以流化床设备对盐酸苯丙醇胺微丸进行包衣试验。

Phenylpropanolamine hydrochloride pellets were coated in fluid bed with Aquacoat and Surelease as coating meterial .

以MCC为稀释剂，3%HPMC水溶液为粘合剂，采用离心造粒法，在优化条件下可制得表面较为光滑、圆整度较高的万氏牛黄清心微丸。

Wanshi Niuhuang Qingxin pellets with perfect shape and surface characteristics were prepared in a centrifugal granulator by using MCC as filler and 3 % HPMC solution as adhesive agent under optimum condition .

结果制备的微丸质量良好，苦参碱缓释微丸需要热处理，适宜的热处理温度为60℃，热处理时间为12h，体外释放曲线符合一级动力学方程。

RESULTS The drug-containing pellets were prepared well and the coated pellets needed thermal treatment at 60 ℃ for 12 h. The curve of cumulative drug release was accorded with the first grade equation .

鱼油微丸中EPA-E和DHA-E的含量测定

Determination of EPA-E and DHA-E in Fish Oil Pills by Gas Chromatography

本研究以GFN为模型药物，采用挤出-滚圆技术制备载药量80%的骨架微丸。

In this study , about 80 % drug loading matrix pellets of Guaifenesin prepared by extrusion-spheronization technology .

根据马来酸曲美布汀紫外吸收特性，建立了其缓释微丸制剂的紫外分光光度法（UV）和反相高效液相色谱（RP-HPLC）的含量及有关物质的测定方法。

On the base of characteristic ultraviolet absorption of trimebutine maleate , the ultraviolet spectrophotometry ( UV ) and reverse-phase high performance liquid chromatography ( RP-HPLC ) methods were developed to determine the trimebutine maleate content and for some relevant impurities in pellets .