尿酸盐结晶

根据临床表现、生化检查及X射线检查即可确诊，滑膜或关节液检查到尿酸盐结晶是诊断的重要依据。

The detection of urate crystal by synovium and synovial fluid is the key basis for diagnose .

尿液尿酸盐结晶的检测对痛风的诊断具有临床意义。

Although patient with Gout has no nephrolithiasis , the urate crystal detected in urine has a important clinical significance for Gout diagnosis .

痛风（Gout）表现为一种由尿酸盐结晶沉积在关节所引发的炎症性关节炎，通常与高尿酸血症（Hyperuricemia，HUA）相关。

Gout is a type of inflammatory arthritis that is triggered by the crystallization of uric acid within the joints and is often associated with Hyperuricemia ( HUA ) .

结论：TGF-β1可能通过自分泌和旁分泌刺激尿酸盐结晶周围单核细胞原位增殖而促进异物肉芽肿形成，且在肉芽肿纤维化过程中发挥了重要作用。

Conclusion : TGF - β 1 promotes the forming of granulomas by stimulating the proliferation in situ of mononuclear cells through autocrine and paracrine , and plays important roles in fibrosis of granulomas .

方法1.采集痛风病人痛风结节中的尿酸盐晶体，应用偏振光显微镜观察晶体形态，以证实其结晶为尿酸盐结晶。

Crystal was collected from gout tophi . It had confirmed that are monosodium urate crystals by polarizing microscope .

尿尿酸盐晶体是尿酸在尿液中处于过饱和状态的标志，通过检测痛风患者尿液尿酸盐结晶，探讨痛风患者尿液尿酸盐结晶对痛风早期诊断和评价病情的临床意义。

The urate crystal appeared in urine is a marker of uric acid in super-saturation . It is very important to detect urate crystal in urine of Gout patient for diagnosis and assessment of Gout . 3 .