周期性蛋白

药物处理后细胞周期依赖性蛋白激酶抑制剂p21表达增高，AR呈时间及剂量依赖性被清除。

TSA depleted AR both in a dose and time dependent manner . Moreover , the expression of cell cycle-dependent kinase inhibitor , p21 , was induced .

细胞周期依赖性蛋白激酶（cyclin-dependentkinases，CDKs）是细胞周期调控机制的核心，CDKs与相应的细胞周期素（cyclin）结合是细胞周期各类分子事件的启动和进行的必要条件。

Cyclin-dependent kinases ( CDKs ) are the core of cell cycle regulation , which is essential for initiating and processing the cell cycle as they interact with their cyclin partners .

研究发现靛玉红对人体广泛存在的细胞周期依赖性蛋白激酶（CDK）、Src激酶相关的肿瘤细胞生长有抑制作用。

The inhibitory effect of indirubin and its derivatives on cell growth was found in some human tumor cell lines relating with cyclin dependent kinase ( CDK ) or Src kinase which widely exists in human bodies .

全脑缺血再灌注损伤大鼠海马细胞周期依赖性蛋白激酶-5的变化

The Alterations of Cyclin-dependent Kinase 5 in the Hippocampus of Global Ischemia-reperfusion Rat Brains

细胞周期依赖性蛋白激酶3（CDK3）的研究进展

Advances on Research of Cyclin-dependent Kinases 3

卡配因I-细胞周期依赖性蛋白激酶5通路在血管性痴呆小鼠海马中的变化

The change of Calpain I-cyclin-dependent protein kinase 5 pathway in hippocampus of mice with vascular dementia

周期素依赖性蛋白激酶5（CDK5）在大鼠脑发育过程中的表达及其分布

Expression and distribution of cyclin-dependent kinase 5 ( cdk5 ) in the developing rat brain

通过诱导细胞周期素依赖性蛋白激酶抑制物（cki）表达，抑制细胞周期素（cy-clin）和细胞周期素依赖性蛋白激酶（cdk）表达使细胞周期停滞于某一时期。

It can induce the expression of cyclin dependent kinase inhibitors ( CDKIs ), that may suppress cyclin and cyclin dependent kinases ( CDKs ), so it makes cell stagnate some phase in cell cycle .

其中细胞周期素依赖性蛋白激酶（CDKs）在细胞周期调节中起着关键作用，主导细胞周期的启动、进行和结束，已经成为抗癌药物筛选的新的靶点。

Cyclin-dependent kinases ( CDKs ) play a critical part in the the cell cycle regulation , which control the start and end of the cell cycle . As a new therapeutic target , CDKs inhibitor is expected to become a new generation of anti-cancer drugs .

原代培养海马神经元周期素依赖性蛋白激酶5及其活性在低氧环境中的变化

Changes in the activity of cyclin-dependent kinase 5 in hippocampal neurons cultured primarily under hypoxia

细胞周期蛋白依赖性蛋白激酶4抑制因子a与肿瘤

Cyclin-dependent kinase 4 inhibitor a and tumor

细胞周期素依赖性蛋白激酶抑制剂治疗实验性单纯疱疹性脑炎的效果及其机制

Effect and its mechanism of cyclin dependent protein kinase inhibitor treatment on experimental herpes simplex encephalitis

目的：探讨大脑发育过程中的周期素依赖性蛋白激酶5对神经系统的发生和退行性变的影响。

OBJECTIVE : To probe into the influence of CDK-5 on neurogeny and neural degeneration during cerebral development .

主要观察指标：不同脑区内周期素依赖性蛋白激酶5mRNA及其蛋白的阳性细胞分布及表达状况。

MAIN OUTCOME MEASURES : Distribution and expression of positive cells of CDK-5 mRNA and protein in various brain areas .

周期素依赖性蛋白激酶5对神经干细胞分化及脑发育作用的研究

Studies on the Role of Cyclin Dependent Kinase 5 Invovled in the Differentiation of Neural Stem Cell and the Development of Brain

老年大鼠海马内周期素依赖性蛋白激酶5的表达下调可能与老年性学习记忆减退的发生密切相关。

The declined expression of CDK-5 in hippocampus of senile rats is closely associated with decline of learning and memory in senility probably .

周期素依赖性蛋白激酶5mRNA主要定位于神经元，阳性区域主要分布于大脑皮质、海马、丘脑、下丘脑、小脑及部分神经核团。

CDK-5 mRNA localized mainly in neurons and positive regions distributed mainly in cerebral cortex , hippocampus , thalamus , hypothalamus , cerebellum and a part of nerve nuclei .

结论：脑内周期素依赖性蛋白激酶5的作用贯穿了整个神经发育的各个时期，在新生期、幼年期有较为显著的表达，成年后表达下降，尤以老年期显著。

CONCLUSION : CDK-5 in brain runs through entire phases of neural development , it expresses more significantly in neonatal phase and childhood and declines after growth-up , especially in senile phase .

Wortmannin抑制PI3K途径对白血病细胞周期特异性及BCL-2蛋白表达影响的研究

The Effects of Wortmannin on Leukemia Cells Proliferation Cycle and BCL-2 Expression

进一步研究表明，As2O3对多种肿瘤细胞的细胞毒作用主要表现为诱导凋亡，其中阻滞细胞周期进展及调节细胞周期特异性调控蛋白的表达是其启动凋亡信号转导的主要作用机制之一。

ATO was reported to induce growth inhibition and apoptosis in these cell lines . The cytotoxic effects of ATO on these cell lines mainly included alteration of cell cycle progression and regulation the expression of cell cycle specific proteins .