别构调节

在众多细胞功能调节机制中，别构调节是最为直接，有效并且快速的调节方式。

Among the regulation mechanisms of cellular function , allosteric regulation is the most direct , rapid and efficient way .

之后，我们对所有ASD数据库中的别构调节分子进行了分析，通过与其他来自不同数据库分子的对比，探求别构调节分子的结构和性质特征。

Afterwards , all allosteric modulators from ASD were analyzed in comparison with various compounds from different databases to unveil the structural and qualitative characteristics of allosteric modulators .

因为2,3-BPG是血红蛋白的别构调节物，与血红蛋白等摩尔结合，因此是调节O2和血红蛋白亲和力的重要因素。

Cause 2,3-BPG acts as an allosteric model and combines with the hemoglobin equally in amount . Thus it plays a critical role in adjusting the affinity between O2 and hemoglobin .

依据可旋转键和环系统分析结果可知，别构调节分子结构通常具有较高的刚性。而疏水性较高则是别构调节分子另一个较为重要的特征。

The results show that allosteric modulators are generally constructed by higher structural rigidity , in terms of the number of rotatable bonds and rings ; containing more hydrophobic scaffolds is another important feature for the allosteric modulators .

别构酶活性调节的异位效应模型

A Heterotropic Effect Model for Regulation of the Allosteric Enzyme Activity

别构酶活性调节的一种新模型

A New Model on Regulation of Allosteric Enzyme Activity

有鉴于此，在本项研究中，我们建立了别构数据库（ASD）。这是第一个有关别构调节的网络数据库，共包含336个别构蛋白以及8095个别构调节分子的相关信息。

In the study , we present the AlloSteric Database ( ASD ) which is the first online database that contains 336 allosteric proteins and 8095 modulators .