分子伴侣
- 名chaperone;chaperonine;molecular chaperone
![分子伴侣](../cache/1172888.jpg)
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这些差异蛋白质点包括蛋白质合成与分解、分子伴侣、解毒和DAN修复相关蛋白质、三大代谢相关酶类、细胞结构相关蛋白质以及信号传导相关蛋白质六类。
Some of these proteins participated protein synthesis and degradation , or chaperone , or protection and detoxification , or signal trans - duction , while some of them were involved in metabolism or cytoskeleton construction .
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人胃癌组织中分子伴侣蛋白的表达及检测
Expression and Detection of Chaperone Proteins in Human Gastric Cancer
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分子伴侣活性分析发现,辣根过氧化物酶,牛血清白蛋白具有分子伴侣活性,能够抑制胰岛素B链的聚集。
Chaperones activity assay revealed that HRP and BSA possessed chaperone activity to inhibit the B-chain aggregation of insulin .
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有蛋白质、酶和RNA分子伴侣的作用;
It is the molecular companion of protein and RNA ;
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UV辐射可进一步降低硒性白内障α晶状体蛋白的分子伴侣活性。
UV irradiation further decreased chaperone activity of α crystallin from selenite cataractous lenses .
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分子伴侣发挥功能依赖于ATP的结合与水解。
They function in ATP binding and hydrolysis .
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研究结果为进一步认识内质网相关的分子伴侣在AD发病中的作用及防治研究提供了依据。
In conclusion , our research provides some proofs for the role of ER associative molecular chaperone in progress and prevention of AD.
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GRP78/Bip作为内质网固有分子伴侣,在ER应激时表达增高,是ER应激的标记物。
GRP78 / Bip as an inherent molecular chaperone in the endoplasmic reticulum is the marker of ER stress .
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分子伴侣GroEL对青霉素G酰化酶亚基折叠的影响
Effect of GroEL Chaperone on Posttranslational Process of Penicillin G Acylase Gene in E.coli
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人工分子伴侣系统辅助鸡IL-18重组蛋白复性过程中研究的影响因素
Influencing factors in the refolding process of artificial molecular chaperone assisting chicken IL-18 recombination protein
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热休克蛋白(Heatshockprotein,HSP)具有分子伴侣作用,参与肿瘤抗原的加工递呈,在诱导肿瘤免疫反应中发挥重要作用。
As molecular chaperone , heat shock protein ( HSP ) participates in processing and presentation of tumor antigen and plays an important role in eliciting antitumor immunity .
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HSP70具有细胞保护及分子伴侣作用。
HSP 70 functions as cytoprotective protein and molecular chaperon .
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正常条件下,HSP占细胞内蛋白组分的5%,在细胞内作为分子伴侣(chaperone)参与蛋白质的折叠、装配、转运和降解。
HSPs normally constitute up to 5 % of the total intracellular proteins .
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小分子伴侣GroEL(191-345)在E.coli中的表达及其培养条件的优化
Expression and culture optimization of mini-chaperone GroEL ( 191-345 ) in E. coli
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pH跨度为4.8-5.6.不同组织类型中分子伴侣蛋白的分布及pH跨度具有一致性。
These chaperone proteins clustering along the pH gradient were very typical and reproducible , and the distributions of the proteins and the pH range were accordant among the tissues of different types .
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此外,CyP还起着分子伴侣的作用,在应激反应中参与调节信号转导途径,并影响RNA的剪接过程。
In addition , CyP can work as molecule chaperones and plays roles in signalling pathways regulation under stress condition and RNA splicing .
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分子伴侣DJ-1与小肽协同抑制α-突触核蛋白的聚集
Interaction of DJ-1 with Small Peptide to Inhibit the Aggregation of Alpha-synuclein in E.coli
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目的:热休克蛋白47(Heatshockprotein47,HSP47)是一种胶原特异性分子伴侣,存在于内质网内,参与胶原合成的加工修饰过程,在胶原合成及纤维化病理过程中发挥着重要作用。
Objective : Heat shock protein 47 ( HSP47 ) is a collagen-specific molecular chaperone localized in the endoplasmic reticulum ( ER ) of the collagen producing cells .
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研究发现,在体内作为分子伴侣的热休克蛋白90(Heatshockprotein90,HSP90)对肿瘤的发生发展起着重要作用,正逐渐成为肿瘤治疗的新靶点。
It was reported that heat shock protein 90 ( HSP90 ), as a molecular chaperone , plays an important role in tumor development and is becoming a new target for cancer therapy .
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新生多肽结合复合物(nascentpolypeptide-associatedcomplex,NAC)能与核糖体以1:1的化学计量结合,是新生态链离开核糖体后结合的第一个分子伴侣。
Nascent polypeptide-associated complex ( NAC ) binds ribosome at a 1:1 stoichiometry , and is the first molecular chaperone contacting the nascent polypeptide .
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DsbA-DsbA~(mut)融合蛋白作为分子伴侣在原核表达系统中的作用研究
Study of DsbA-DsbA ~ ( mut ) as Molecular Chaperone in Prokaryotic Expression System
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分子伴侣GroEL促进溶菌酶复性动力学
Kinetics of lysozyme refolding facilitated by molecular chaperone GroEL
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为此本文研究了除LepA以外保守GTP酶的分子伴侣活性。
This paper studies the chaperone activity of conservative GTPase except LepA .
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免疫学研究表明,热休克蛋白(HSP)作为分子伴侣(MolecularChaperone)在肿瘤及病毒抗原的MHCⅠ类限制性抗原呈递途径中发挥重要作用。
Many studies showed that heat shock protein ( HSP ), as a molecular chaperone , played important roles in the processing and presentation of MHC-I antigens of virus or tumors .
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因此研究内质网的微细结构,尤其是ER合成的膜蛋白、分泌蛋白和分子伴侣已成为国际上的前沿课题。
So the study of the microstructure of ERs , especially the studies of membrane proteins , secretory proteins and molecular chaperones synthesized by ERs have become the frontiers of the molecular biology all over the world .
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GroEL分子伴侣研究进展
Progress in molecular chaperon GroEL
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热激蛋白(Hsp)作为分子伴侣协助蛋白的重新折叠、稳定、胞内运输和降解,以阻止受损蛋白的累积,维护细胞内环境的稳定。
Heat shock proteins function as molecular chaperones in preventing the accumulation of damaged proteins to maintain cellular homeostasis by refolding , stabilization , intracellular translocation and degradation of proteins .
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但有关内质网分子伴侣GRP78、GRP94在脑发育过程中的作用迄今尚不清楚。
However , the functions of molecular chaperones , especially endoplasmic reticulum chaperones , on brain development are unclear .
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分子伴侣:抑制素(PHB),内质网蛋白ER29(Erp29);
(⑤ molecular ) chaperones : prohibitin ( PHB ) and endoplasmic reticulum protein ER29 ( Erp29 );
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热激蛋白70(hsp70s)具有分子伴侣的功能,其中在非胁迫条件下表达的hsp70s称为热激同源蛋白70(hsc70)。
Heat shock cognate proteins 70 ( hsp70s ) act as molecular chaperones .