中性鞘糖脂

脑胶质瘤中性鞘糖脂抗原的研究

Study on the neutral glycosphingolipids in gliomas

目的探讨N糖基化抑制对肿瘤细胞中性鞘糖脂（NGSLs）合成的影响。

To study the effects of N-glycosylation inhibition on the expression of neutral glycosphingolipids ( N-GSLs ) in cells .

说明GlobN为一类中性鞘糖脂，其结构与组织来源相关。

It suggested that Glob-N is a kind of neutral glycosphingolipids , and its molecular structure is different in different tissues .

CMH为KBv（200）耐药相关中性鞘糖脂

CMH is the multidrug resistance ( mdr ) associated neutral glycosphingolipid in kbv_ ( 200 ) cell line

方法人脑中性鞘糖脂经过加压柱层析，梯度甲醇/氯仿溶液洗脱。对所得到的产物行1H-NMR和13C-NMR测定。

Methods Neutral glycosylsphingolipid was separated from normal human brain by column chromatography with methanol / chloroform solution for gradient elution , and the resultant underwent 1H-NMR and 13C-NMR analyses for identifying the structure of Glob-N.

方法本实验运用改良的Hakomori的方法提取、纯化了脑胶质瘤及胚胎脑的中性鞘糖脂，并行高效薄层层析（HPTLC）。

METHODS A modified Hakomori ′ s method was used to extract and purify the N GSLs from glioma and embryonic brain tissues separately , and analyzed by high performance thin layer chromatography ( HPTLC ) .

中性鞘糖脂也有明显变化。

Meanwhile , neutral glycosphingolipids also showed some obvious alteration .

一种新的中性鞘糖脂显色方法

A new method of visualizing neutral glycosphingolipids

人精子中性鞘糖脂的纯化与分析及其抗体的制备与鉴定

Purification and Analysis of Human Sperm Neutral Glycosphingolipid and Preparation and Characterization of Its Antibody

人子宫平滑肌肉瘤中性鞘糖脂含量、组成及其四糖基组分糖链结构的变化

Changes of Total content , Composition and Carbohydrate Chain Structure of Neutral Glycosphingolipid in Human Leiomyosarcoma

肿瘤相关中性鞘糖脂的实验研究

Investigation on tumor associated neutral glycosphingolipids

免疫活性细胞和肿瘤耐药细胞的中性鞘糖脂表达与肿瘤免疫的相关关系研究

Study on the Relationship of N-GSLs Expression of Immunocompetents Cells and MDR Tumor Cells & Tumor Immunology

凋亡相关蛋白、中性鞘糖脂与人卵巢癌细胞株COC1/DDP多药耐药相关性及逆转的研究

Study of Correlation of Apoptosis Related Protein , Neutral Glycosphingolipids and Multidrug Resistance in Human Ovarian Cell Line COC1 / DDP