zanamivir

Zanamivir was synthesized with salic acid as starting material by enzymatic catalysis method .

以自制唾液酸为起始原料，对扎那米韦的合成工艺进行研究。

At this stage , there are no reports of resistance occurring to zanamivir in immunocompetent patients .

在这种阶段，有免疫力的患者中没有出现扎那米韦耐药的报道。

The viruses , while resistant to oseltamivir , remain sensitive to zanamivir .

这些病毒对奥司他韦具有耐药性，但对扎那米韦仍是敏感的。

Zanamivir remains a treatment option in symptomatic patients with severe or deteriorating illness due to oseltamivir-resistant virus .

所以，如果患者由于受到对奥司他韦具有耐药性病毒的感染而病情严重或症状恶化，仍可采用扎那米韦对其进行治疗。

All other viruses have been shown sensitive to both oseltamivir and zanamivir .

所有其它病毒显示对奥司他韦和扎那米韦都是敏感的。

Zanamivir should be considered as the treatment of choice for patients who develop prolonged influenza illness despite treatment with oseltamivir .

对于采用奥司他韦治疗后仍然出现长时间的流感病症的患者，应当将扎那米韦作为治疗选择。

Patients who are at higher risk of severe or complicated influenza should be treated with oseltamivir or zanamivir as soon as possible .

对罹患严重性流感或伴有并发症流感具有较高风险的病人，应尽快用奥司他韦或扎那米韦进行治疗。

Zanamivir and oseltamivir bind differently at the neuraminidase catalytic site and this contributes to different drug resistance profiles .

扎那米韦和奥塞米韦结合在神经氨酸酶的不同催化位点，这就导致了这种耐药情况不同的发生。

Many advanced countries stock up on oseltamivir and zanamivir , two varieties of the same class of drugs that stops the H5N1 virus from multiplying .

许多发达国家储备了药物奥司他韦（oseltamivir）和扎那米韦（Zanamivir）。它们是阻止H5N1病毒繁殖药物的两个品种。

Discuss whether the use of Tamiflu ( oseltamivir phosphate ) or Relenza ( zanamivir ) is appropriate for you .

讨论看是否要用达菲（奥司他韦磷酸盐）或扎那米韦都适合于你。

Growing international experience in the treatment of pandemic H1N1 virus infections underscores the importance of early treatment with the antiviral drugs , oseltamivir or zanamivir .

在治疗H1N1大流行性流感病毒感染方面，越来越多的国际经验显示了使用奥司他韦和扎那米韦抗病毒药物进行早期治疗的重要性。

The virus is sensitive to oseltamivir and zanamivir , but resistant to amantadine and rimantadine .

该新病毒对奥司他韦和扎那米韦较敏感，但对金刚烷胺和金刚乙胺具有抗药性。

They say zanamivir is as effective as oseltamivir , has fewer side effects , and that the bird flu virus is less likely to become resistant to it .

他们认为，后者与奥司他韦一样有效，并且具有较小副作用，同时禽流感病毒不大可能对它产生抗药性。

The virus with this mutation remains sensitive to the antiviral drugs , oseltamivir and zanamivir , and studies show that currently available pandemic vaccines confer protection .

这种已变异的病毒仍然对抗病毒药物奥司他韦【注：即达菲】和扎那米韦敏感，研究表明当前的流感疫苗仍然可以提供保护。

At the start of the pandemic , data from the Centers for Disease Control and Prevention ( USA ) showed that the new virus was sensitive to oseltamivir and zanamivir .

在大流行开始时，美国疾病预防控制中心的资料显示，此新病毒对奥斯他韦和扎那米韦具有敏感性。

Laboratory testing on these swine influenza A ( H1N1 ) viruses so far indicate that they are susceptible ( sensitive ) to oseltamivir and zanamivir .

目前实验室检测证实这些猪流感病毒A（H1N1）对奥司他韦和扎那米韦敏感。

Most swine influenza viruses have been susceptible to antiviral medications such as neuraminidase inhibitors ( oseltamivir and zanamivir ) .

大多数猪流感病毒对抗病毒药物，例如：抑制剂（奥司他韦和扎那米韦）很敏感。

All of the resistant viruses carried the same H275Y mutation , indicating resistance to oseltamivir but susceptibility to the second antiviral drug , zanamivir .

所有这些耐药病毒均出现同样的H275Y变异，显示出对奥斯他韦的耐药性，但对第二种抗病毒药物扎那米韦仍是敏感的。

The recommended alternative to zanamivir in patients with laboratory evidence of influenza A , a negative test result , or no testing is the combination of oseltamivir plus rimantadine .

作为扎那米韦的替代治疗方案，推荐甲型流感实验室检查阳性、阴性或未检查的患者联合应用奥司他韦和金刚乙胺。

GSK have added that all tested influenza virus subtypes have shown no resistance to zanamivir and that they have sufficient supplies for the2008-2009 flu season .

葛兰素史克（GSK）补充说，所有的受试流感病毒的亚型对扎那米韦没有耐药性，并且他们可以在2008-2009年感冒流行季节保证充足的供应。美国报告的流感毒株耐奥斯他韦（达菲）

There are four different antiviral drugs that are licensed for use in the US for the treatment of influenza : amantadine , rimantadine , oseltamivir and zanamivir .

这四种药品对大部-猪流感病毒都有效，但最近从人类分-出来的猪流感病毒对金刚烷胺和金刚-乙胺有抗药性。

All of these viruses show the same H275Y mutation that confers resistance to the antiviral oseltamivir , but not to the antiviral zanamivir .

所有这些病毒都呈现出同样的H275Y变异，对奥司他韦抗病毒药物产生了耐药性，但却并不对扎那米韦抗病毒药物具有耐药性。

In August , researchers suggested in The Lancet that H5N1 would be less likely to become resistant to zanamivir also called Relenza than to Tamiflu ( see Bird flu : in favour of contingency plans ) .

今年8月，科学家在《柳叶刀》上说，H5N1型毒株对扎纳米韦（商品名称Relenze）产生抗药性的可能性要小于达菲。

There are two classes of such medicines , 1 ) adamantanes ( amantadine and remantadine ), and2 ) inhibitors of influenza neuraminidase ( oseltamivir and zanamivir ) .

这种药物有两类：1）烷胺类药物（金刚烷胺和金刚乙胺），2）流感的神经氨酸酶抑制剂（奥司他韦和扎那米韦）。