transactivator

Objective To investigate the relationship between the SNP G-944C in class ⅱ transactivator ( C ⅱ TA ) gene promoter ⅳ and disease susceptivity of chronic HBV infection .

目的探讨MHCⅡ类反式激活因子（CⅡTA）启动子Ⅳ区G-944C基因多态性与慢性乙型肝炎病毒（HBV）感染发病易感性的关系。

Study of Bovine Immunodeficiency Virus Transactivator Functional Domains

牛免疫缺陷病毒反式激活因子功能域的研究

Objective To investigate the transactivator function of the C terminal truncated middle surface protein of the hepatitis B virus .

目的探讨乙型肝炎病毒（HBV）表面抗原中蛋白羧基末端缺失突变体（MHBst）的反式激活功能。

Suppression of MHC Class II Molecules by Antisense RNA of MHC Class II Transactivator

CIITA反义RNA抑制MHcII类分子表达

MHC Class II Transactivator ( CIITA ) Regulates the Expression of HLA Molecules in Tumor Cells

MHcII类反式激活蛋白调控肿瘤细胞HLA分子的表达

Objective To investigate the inhibiting effect of class ⅱ major histocompatibility complex transactivator ( C ⅱ TA ) anti-sense cDNA on MHC ⅱ molecules expression .

目的探讨Ⅱ类主要组织相容性复合物（MHCⅡ）激活因子（CⅡTA）的反义cDNA对细胞表面MHCⅡ类分子表达的抑制。

Objective : To investigate the role of MHC class ⅱ Transactivator ( C ⅱ TA ) in expression of HLA molecules in five human malignant hematological cell lines .

目的：探讨5种血液病细胞株细胞的HLA-Ⅱ类抗原表达，以及对IFN-γ诱导HLA分子表达的反应性与MHCⅡ类分子反式激活因子（CⅡTA）表达的关系。

The class ⅱ transactivator ( C ⅱ TA ) expression appears to be an absolute requisite for expression of MHC - ⅱ, whether constitutive or inducible .

无论是组成型还是诱导型表达MHC-Ⅱ类分子，MHC-Ⅱ类分子反式激活因子（CⅡTA）都是绝对必需的。

Above date confirmed primarily that mutant C ⅱ TA suppressed the expression of MHC class ⅱ molecule by competitive binding with transactivator for the normal endogenous wild type C ⅱ TA molecule .

初步证实CⅡTA突变体是通过与胞内的野生型CⅡTA竞争性结合反式激活蛋白，来抑制MHCⅡ类分子的转录和表达。

AIM : To explore the correlation between the expressions of HLA gene and its related gene , and expression of class II transactivator ( CIITA ) gene induced by IFN - γ in human o-varian cells .

目的：探讨人卵巢癌细胞中HLA分子及其相关基因的表达与IFN-γ诱导HLA分子表达的相互关系。

Methods The expression of MHC molecules and MHC class ⅱ transactivator ( C ⅱ TA ) protein were detected with Western blot , immunohistochemistry and flow cytometry . The expression of C ⅱ TA gene was determined with RT-PCR .

方法采用westernblot、免疫组化和（或）流式细胞术检测肿瘤细胞CⅡTA蛋白及MHC分子表达，逆转录PCR检测肿瘤细胞CⅡTA基因表达。