smad

TGF β 1 could increase the MMP 2 activities in both Smad 3 mutant and wild type fibroblasts .

TGFβ1可以提高野生型成纤维细胞MMP2的活性；

Objective : To investigate the relationship between TGF - β _1-induced epithelial to myofibroblast transition ( EMT ) of human kidney tubular cells ( HKC ) and its cellular smad mediated signaling pathway .

目的：研究转化生长因子β1（TGFβ1）诱导人肾小管上皮细胞（HKC）转分化作用与其细胞内信号传递途径的关系。

TGF - β 1 / Smad signal pathway took part in the development of hydrocephalus , while the mechnism by which this occurs remains obscure . It is estimated that the pathway exerts different roles during different stage of hydrocephalus .

TGF-β1信号通路参与该小鼠脑积水的发生、发展过程，但其具体作用机制尚不明确，推测该信号通路可能在脑积水发生的不同阶段发挥不同的作用。