rxr

Expression and significance of PPAR γ and RXR α in gastric carcinoma

胃癌组织中过氧化物酶体增殖因子活化受体γ和维甲酸受体α的表达及意义

Research on Expression of Landrace RXR α Gene on Different Days

不同日龄大白猪视黄素X受体α基因的表达研究

Experimental Researches of PPAR γ / RXR α Targeting Treatment in Multiple Myeloma

以PPARγ/RXRα为靶点治疗多发性骨髓瘤的实验研究

RXR inhibitors can lead to severe deformity on amphibian embryos .

研究表明RXR抑制剂能导致两栖类动物胚胎发育的严重畸形。

Inhibition of RXR α transcriptional activity by TPA was detected by CAT assay .

用CAT分析检测RXRα转录活性的抑制。

Advances in studies on selective RXR ligands

选择性RXR配体的研究进展

Suprabasal RXR mutant in transgenic mouse inhibits epidermal basal keratinocyte proliferation

表皮基底上层变异维甲酸X受体转基因鼠抑制表皮基层角朊细胞增殖

Inhibition of PPAR γ and RXR agonists on aromatase activity and its mRNA transcriptional level in human ovarian granulosa cells

PPARγ和RXR激动剂抑制人卵巢颗粒细胞芳香化酶活性和其mRNA的水平

The Expression , Regulation and Significance of RXR α in Liver Cancer and Identification of Natural Leads That Induce RXR α to Export Resulting in Extensive Apoptosis

RXRα在肝癌细胞中的表达与调控以及一种通过诱导RXRα出核引起细胞凋亡的天然化合物的鉴定

AtRA exerts its effects by binding the retinoic acid receptor ( RAR ) and retinoid X receptor ( RXR ) .

己证实atRA通过核内维甲酸受体（RAR）和维甲类X受体（RXR）的激活而起作用。

From chronic non atrophic gastritis , chronic atrophic gastritis to gastric carcinoma , expressions of PPAR γ and RXR α showed an ascending tendency .

从慢性胃炎、胃黏膜不典型增生到胃癌，PPARγ和RXRα阳性率呈递增趋势；

Objective To study the alteration of retinoid X receptor α ( RXR α) with the treatment of tazarotene in active psoriasis vulgaris and investigate the mechanism .

目的研究他扎罗汀治疗进行期寻常型银屑病前后异维甲酸受体α（RXRα）的变化，并探讨其作用机制。

RXR belongs to super family of nuclear hormone receptor , which contains three subtypes (α,β and γ), and regulates many aspects of metazoan life as ligand activated transcriptional factor .

其中RXR属于核激素受体超家族，它包括α、β和γ三种亚型，它们可以作为配体激活型转录因子调控多细胞动物生命的许多方面。

The ligands of the retinoic acid acceptor RXR cannot induce teratogenesis , but they can enhance the teratogenesis of the RAR stimulus .

视黄酸受体RXR的配体无致畸活性，但是可加强RAR激动剂的某些致畸郊应。

Regulatory Function of PPAR γ - LXR α / RXR α - ABC1 / CYP7A1 Pathway in Cholesterol Reverse Transportation and Metabolism

PPARγ-LXRα/RXRα-ABC1/CYP7A1途径在胆固醇逆向转运和胆固醇代谢中的调控作用研究

Objective To investigate the regulatory effects of peroxisome-proliferator activated receptor γ ( PPAR γ) and retinoid X receptor ( RXR ) agonists on the aromatase activity in human ovarian granulosa cells .

目的探讨过氧化酶体增殖物激活受体γ（PPARγ）和维甲类X受体（RXR）激动剂对人卵巢颗粒细胞芳香化酶活性的调节作用。

Conclusion Tazarotene upregulates the expression of RXR α and inhibits proliferation and induces apoptosis of keratinocytes through facilitating the binding of RAR γ RXR α in psoriatic epidermis .

结论他扎罗汀通过促进RARγRXRα的结合，上调银屑病表皮基底上层中RXRα的表达，抑制表皮角质形成细胞的增殖并诱导凋亡。

Initially , atRA activates a heterodimer RAR / RXR , which further recognizes and binds to retinoic acid receptor response element ( RARE ) consensus sequence , thereby activating or repressing target gene transcription .

AtRA可激活异二聚体RAR/RXR，后者通过识别和结合维甲酸受体反应元件（RARE），进而引起靶基因的转录激活或转录抑制。

Method : 50 spontaneous abortion patients and 40 normal early pregnant women requesting pregnancy termination were determined for mutations in the exon 2 ~ 10 of RXR α gene in their chorionic villi by PCR-SSCP-silver stain and DNA sequencing .

方法：用PCRSSCP银染法和DNA测序法检测了自然流产50例和正常早孕要求人工流产40例的胚胎绒毛组织中RXRα基因的外显子2～10的突变。

However , it is still uncertain about the role of RXR in the adipocytes differentiating process . In addition to the pathway of RXR acting as a nuclear receptor , whether there is other independent signal pathway regulated by RXR or not still needs to be further studied .

但有关RXR的作用机制尚无定论，除了RXR作为其它核受体的配体这一途径之外，是否还存在独立的RXR调控的信号通路仍是需要深入研究的问题。