noxa

The study of the expression of Noxa caused by DNA single-strand damage in cortical neurons on ischemic-like condition

缺血皮质神经元DNA单链损伤引发Noxa表达的研究

The Experiment Study of the Primary DNA Damage and the Expression of Bax and Noxa in Mouse Cortical Neurons after Ischemia / Reperfusion Condition

缺血/再灌注皮质神经元DNA原发损伤与Bax、Noxa蛋白表达的实验研究

Apoptosis launched by p53 was considered as a sequence-specific activators of transcription activation of the pro-apoptotic genes , such as bax , Noxa , PUMA , and so on .

普遍认为p53发动凋亡是通过作为序列特异性的转录激活因子活化了前凋亡基因，如Bax、Noxa和PUMA等。

Now among proteins involving in apoptosis , Bcl-2 proteins family is that we care most . Bax and Noxa of Bcl-2 proteins family are related to apoptosis caused by DNA damage , but at neurons we don 't prove yet .

目前研究最多的凋亡调控蛋白为Bcl-2家族蛋白，研究发现其促凋亡成员Bax、Noxa与DNA损伤引起的细胞凋亡有密切关系，但在神经元上尚未得到证明。

Many different classes of chemotherapeutic drugs induce apoptosis by damaging DNA , leading to activation of the transcription factor p53 , which in turn mediates apoptosis primarily by up-regulation of pro-apoptotic proteins such as Puma and Noxa .

很多不同种类的化疗药物通过损伤细胞DNA，导致转录因子P53的激活，然后P53通过上调促凋亡蛋白例如Puma和Noxa来介导凋亡。