methylcobalamin

Objective : To study the clinical effect of acupuncture combined with methylcobalamin in the treatment of diabetic peripheral neuropathy .

目的：观察针灸联合甲钴胺治疗糖尿病周围神经病变的临床疗效。

Neuroprotective effects of vitamins B_ ( 12 ) and its analog methylcobalamin on the hypoglycemia injured retinal neurons in vitro

维生素B（12）及其衍生物甲钴胺对低糖导致的视网膜神经元损伤的保护作用

The effect of methylcobalamin on the secretion of testosterone in STZ induced diabetic rats

甲基维生素B（12）对链脲佐菌素诱导的糖尿病大鼠睾酮分泌功能的影响

Curative effects of ginkgo flavone glycoside and methylcobalamin on diabetic peripheral neuropathy

银杏黄酮甙和甲基B（12）联合治疗糖尿病周围神经病变的疗效观察

Comparison of reducing the homocysteine level in type 2 diabetic mice between cyanocobalamin and ( methylcobalamin ) treatment

比较氰钴胺和弥可保降低2型糖尿病小鼠同型半胱氨酸的作用

Comparison of the efficacy of methylcobalamin ( MC ) and cyanocobalaminB_ ( 12 ) in treatment of peripheral facial palsy

弥可保和维生素B（12）治疗周围性面瘫的疗效比较

The following outcomes were assessed : effectiveness of clinical signs and symptoms , sensory nerve and motor nerve conduction velocities and serious adverse events of methylcobalamin .

采用下列指标对甲基维生素B12治疗糖尿病周围神经病变的疗效和安全性进行评价：临床症状体征的总有效率、感觉及运动神经传导速度以及严重不良反应的发生率。

Objective To compare the effect and advantage of methylcobalamin for the treatment of paralytic strabismus prospectively with Vitamine B_ ( 12 ) .

目的对照观察弥可保和普通维生素B12治疗眼肌麻痹性斜视的临床效果，评估弥可保的治疗有效性和优越性。

Conclusion The curative effect of ginkgo flavone glycoside combined with methylcobalamin on diabetic peripheral neuropathy of is better than that of the treatment only with a single agent .

结论银杏黄酮甙和甲基B12联合治疗糖尿病周围神经病变较单独应用更为有效。

IGF-1 mRNA / peptide changes : Tissue IGF-1 mRNA increased significantly in methylcobalamin + insulin treated groups than that in insulin treated groups , respectively ( P 0.05-0.01 ) .

组织胰岛素样生长因子1mRNA表达及其肽含量变化甲钴胺+胰岛素治疗组组织胰岛素样生长因子ⅠmRNA含量均不同程度高于胰岛素治疗组（P0.05～0.01）。

Effect of methylcobalamin and vitamin B_ ( 12 ) on the contents of methylmercury , immune toxicity and behavioral teratogenesis caused by methylmercury in rats

甲基维生素B（12）、维生素B（12）降低甲基汞含量及免疫与行为毒性作用的研究

The basis of the two groups are therefore correspondingly diabetes treatment and control group was given methylcobalamin tablets western clothes , the treatment group based on the therapy in the control group given oral hypoglycemic Bi-pass .

两组均予糖尿病基础治疗，对照组给予西药甲钴胺片口服，治疗组在对照组治疗基础上给予消渴痹通口服。

Similarly , tissue IGF-1 mRNA contents were obviously higher in methylcobalamin + insulin treated group 2 than that in insulin treated group 2 ( P 0.05 ), but lower than that in NC group ( P 0.01 );

甲钴胺+胰岛素治疗2组明显高于胰岛素治疗2组（P0.05），但低于正常对照组（P0.01）；

Nerve electrophysiological data changes : Month 2 and 3 , SNCV , MNCV and EPA were significantly higher in methylcobalamin + insulin treated group 1 than in insulin treated group 1 ( P < 0.05 );

神经电生理指标变化病程2和3个月时，甲钴胺+胰岛素治疗1组感觉和运动神经传导速度及波幅明显高于胰岛素治疗1组同期（P<0.05）；

By month 3 , IGF-1 mRNA level in methylcobalamin + insulin treated group 2 was not significantly different from that in insulin treated group 2 . The IGF-1 peptide levels in nerve tissue changed approximately parallel to IGF-1 mRNA level over time course .

病程3个月时，甲钴胺+胰岛素治疗2组神经组织与胰岛素治疗2组无差异。甲钴胺对组织胰岛素样生长因子1肽含量变化的影响趋势与对胰岛素样生长因子1mRNA基本平行。

Two weeks after diabetic model was established , the sciatic tissue IGF-1 mRNA contents were obviously higher in methylcobalamin + insulin treated group 1 than that in insulin treated group 1 ( P < 0.05 ), but not significantly different from that in NC group ;

糖尿病成模后2周时，坐骨神经甲钴胺+胰岛素治疗1组组织胰岛素样生长因子1mRNA含量显著高于胰岛素治疗1组（P<0.05），与正常对照组差异不明显；

Methods : The model rats suffering from diabetes were induced by streptozotocin ( STZ ) . 1 week after STZ injection diabetic rats were given Chinese herb or methylcobalamin . At the end of the experiment , MNCV of the sciatic were detected with evoked electromyogram .

方法：采用链脲佐菌素（STZ）诱发糖尿病大鼠模型，分别用益气活血方和弥可保进行治疗，用药4周后测定大鼠坐骨神经的运动神经传导速度（MNCV）。