gik

A clinical study of GIK on the prevention of myocardial reperfusion injury

极化液防治心肌缺血一再灌注损伤的临床研究

Studies of the Dysfunction of Islets β Cell and the Effects of GIK Treatment in Trauma Patients

严重创伤患者胰岛β细胞功能不全与极化液临床干预效果研究

The Research on the Protection of GIK Effect on Acute Cerebral Ischemic Reperfusion

急性脑缺血再灌注中极化液的保护作用实验研究

P 0.01 . Conclusion : GIK may have protective function to ischemic cerebral tissue .

两组比较P＜0.01。结论：GIK对缺血脑组织具有保护作用。

To discuss the curative effect of polarization liquid ( GIK ) on cerebrovascular diseases .

目的：探讨极化液（GIK）对缺血性脑血管病的疗效。

Discussion on Roles of Glycometabolism Disorder in MODS in Trauma Patients and Clinical Application of GIK

糖代谢障碍在创伤多器官功能不全综合征中的作用及极化液的临床应用探讨

Comparative study on myocardial protection by high dose GIK and low dose GIK during myocardial ischemia and reperfusion

高、低剂量极化液对缺血/再灌注心肌保护作用的对比研究

The roles of glucose metabolism disorder and treatment with GIK on organ dysfunction in patients after trauma

糖代谢障碍与极化液治疗对创伤后器官损害及预后的影响

Study on Early Diagnosis and Individual Treatment with GIK for Dysfunction of Glycometabolism and MODS Caused by Trauma

创伤糖代谢障碍与MODS早期诊断和极化液个体化治疗研究

GIK and GIK-magnesium sulfate protection for the isolated rat heart from myocardial ischemia / reperfusion injury

极化液及加镁极化液对缺血再灌注心脏的保护作用

The effects of high dose GIK on hemorheological characteristics and blood glucose in a canine model of myocardial ischemia and reperfusion

葡萄糖-胰岛素钾液对心肌缺血/再灌注犬血液流变学和血糖的影响

Effects of Tight Control of Blood Glucose by Intensive GIK Therapy on the Inflammatory Response And Body Weight of Severely Thermal Trauma Rat

极化液严格控制血糖对严重烫伤大鼠炎症反应和体重的影响

Influence of GIK solution on the fluidity and lipid peroxides of erythrocyte membrane in patients undergoing cardiac valvular replacement

GIK溶液对瓣膜置换术病人红细胞膜流动性和脂质过氧化物的影响

The concept of metabolic protection to ischemic myocardium with glucose-insulin-potassium ( GIK ) was initially proposed in 1960 's.

20世纪60年代最早提出通过输注极化液（葡萄糖-胰岛素-钾，glucose-insulin-potassium，GIK）调节AMI病人代谢的概念。

Objective : To study the roles of glucose metabolism disorder and treatment with GIK on organ dys - function in patients after trauma .

目的：探讨糖代谢障碍与极化液治疗对创伤后器官损害及预后的影响，为极化液辅助改善创伤后器官损伤提供依据。

Objective To evaluate the effects of high dose glucose-insulin-potassium ( GIK ) solution on hemodynamics in patients with acute myocardial infarction ( AMI ) .

目的评价高浓度极化液（GIK）对急性心肌梗死（AMI）患者血液动力学的影响。

Conclusion GIK can lighten the nerve toxicity of Glu , Asp and NO , and protect on the ischemic organisation .

应用GIK后较缺血组有明显降低。结论GIK能减轻Glu、Asp、NO的神经毒性，起到对缺血脑组织的保护作用。

There were no significant differences in apoptosis index , contents of Fas and Bcl 2 protein between GIK and insulin groups ( P > 0.05 ) .

GIK组和胰岛素组心肌细胞凋亡指数及Fas，Bcl-2蛋白含量比较，差异无显著性意义（P>0.05）。

This result reveals that cardiovascular functions during acute hypoxia can be rapidly , markedly but temporarily improved when a small volume of GIK is administered intravenously .

结果提示：急性低氧时，GIK一次小量静注可迅速显著改善心血管功能。

METHODS : Forty eight healthy male rabbits were randomly divided into 3 groups of 16 each : control group , insulin group and glucose insulin potassium ( GIK ) group .

方法：选择健康雄性家兔48只，按随机抽签法分为3组：对照组，胰岛素组，葡萄糖-钾-胰岛素（glucose-insulin-potassium，GIK）组，每组16只。

Glycometabolism disorder is a risk factor of MODS . Early treatment with GIK is safe and effective on the preventation and treatment of MODS in trauma patients .

糖代谢障碍是MODS发生发展的危险因素，早期使用极化液可作为营养救治MODS有效安全药物。

Meta analysis of all the clinical trials about GIK came to the conclusion that GIK had reduced AMI mortality by 18 % that was only critical statistical significance .

对迄今所有的GIK临床试验荟萃分析显示GIK使AMI死亡率降低18%，仅有临界的统计学意义。

AIM : To study the effects of glucose-insulin-potassium ( GIK ) cocktail on ventricular arrhythmias induced by severe myocardial ischemia ( MI ) / reperfusion ( R ) in anesthetized dogs .

目的探讨葡萄糖-胰岛素-钾合剂（GIK）对犬重度心肌缺血/再灌注（MI/R）后心律失常和心电图的影响。

At 4 hours after reperfusion ,± LVdP / dtmax decreased by 11.4 % and 10.1 % respectively in GIK plus HG group compared with GIK group ( P 0.05 ) . 3 .

与GIK组相比，GIK+HG组再灌注4h的±LVdP/dtmax分别下降了11.4%和10.1%（P0.05）。

In comparison with those of control group , the levels of blood glucose , cortisol and growth hormone were significantly reduced ( P0.05 ) and the levels of c-peptide and insulin increased ( P0.05 ) in GIK group .

同时，GIK组血糖、生长激素和皮质醇浓度显著低于对照组（P0.05），而胰岛素、C肽浓度显著高于对照组（P0.05）。

After treatment with puerarin , plasma levels of ET , RA and AT - ⅱ were recovered to normal in 3 days , but these data recovered to nearly normal until 7 ~ 14 days in group with GIK treatment .

经葛根素治疗后血浆ET及RA、AT－Ⅱ在3天内恢复至正常，而经极化液治疗组血浆RA及AT－Ⅱ于7天方恢复接近正常，ET在14天才降至正常。

However , myocardial ATP , glycogen and MDA levels showed no significant difference as compared with those before ischemia in the GIK group . The release of myocardial enzymes into the serum was comparatively less than those in the control group .

极化液组再灌注后心肌ATP、糖原、MDA含量与缺血前比较无显著性差异，血清心肌酶释放量较对照组低。

CONCLUSION : The above results suggest that GIK can shorten QRS duration of ventricular arrhythmias induced by MI / R and that insulin , rather than GK , may affect the ventricular depolarization during MI / R.

结论GIK对犬重度MI/R引起的室性心律失常无显著改善作用，但可缩短缺血/再灌注心脏的QRS波群时间，提示胰岛素可能影响MI/R心室除极。

AIM : To study the effects of high dose glucose insulin potassium ( GIK ) and low dose glucose insulin potassium cocktail on cardiac myocyte apoptosis and cardiac functional recovery following myocardial ischemia / reperfusion ( MI / R ) .

目的：探讨两种剂量葡萄糖胰岛素钾液（GIK）对心肌缺血/再灌注（MI/R）后心功能和细胞凋亡的影响。

AIM : To investigate whether glucose-insulin-potassium ( GIK ) cocktail given at different ( occasion ) will influence the effects of GIK on cardiac myocyte injury and cardiac functional recovery following myocardial ischemia / reperfusion ( MI / R ) .

目的：探讨不同时间开始给予极化液（葡萄糖-胰岛素-钾液，GIK）对犬心肌缺血/再灌注（MI/R）后心脏功能及心肌细胞损伤的影响。