chromatin remodeling

Chromatin Remodeling and Flowering Time Control in Higher Plant

染色质重塑和高等植物开花时间控制

Chromatin remodeling plays an important role in DNA replication , damage repair and gen transcription .

染色质重塑在DNA复制、损伤修复和基因转录中发挥着重要的作用。

Chromatin remodeling plays an important role in DNA repair , gene transcriptional regulation .

染色质重构是DNA修复、基因表达调控过程中的一个重要环节。

Chromatin remodeling is achieved through ATP dependent physical modifications and covalent chemical reactions .

染色质重塑主要包括2种类型：一种是依赖ATP的物理修饰，另一种是依赖共价结合反应的化学修饰。

The key to nuclear transplantation with adult cells lies in nuclear reprogramming or chromatin remodeling .

成年细胞核移植的关键在于核的再编序或核染质的再塑造。

There are few reports about chromatin remodeling in current researchs , because the research method is the main limitation .

目前有关染色质重塑的研究较少，主要是研究方法的限制。

Epigenetic regulations mainly involve the mechanism of histone modification and chromatin remodeling regulating gene transcription .

表观遗传是一门新学科，主要研究染色质修饰和染色质重塑等对基因转录表达的调控机制。

Progress on chromatin remodeling factor CHD

染色质重构因子CHD蛋白家族的研究进展

BAF chromatin remodeling complex and its downstream Wnt signaling , heart development related genes were down-regulated .

并且BAF染色质重塑复合物及其下游Wnt信号和部分心脏发育关键基因的表达也出现下调。

The SWI / SNF Complex - Chromatin Remodeling and Cancer

SWI/SNF复合物-染色体重构和肿瘤

However , MN were also reported to form during interphase , due to disruptions in chromatin remodeling , or oncogene amplification .

但是目前有多篇报道称由于染色体重塑异常、癌基因扩增等原因可以导致细胞在分裂间期形成微核。

Chromatin remodeling factors are major factors to regulate chromatin structure through recognizing specific chromatin modification marks and altering nucleosome position or composition .

染色质变构因子是一类重要的因子，其通过识别特定的染色质修饰标志和改变核小体的位置或组成，从而调节染色质的结构。

Present studies indicate that the interactions between trans-acting factors and corresponding DNA cis-acting elements are the basis of chromatin remodeling and gene transcription regulation .

已有研究表明DNA顺式作用元件与反式作用因子之间的相互作用是染色质重塑和基因转录调节的基础。

Rsf-1 / HBXAP plays a role in chromatin remodeling and transcriptional regulation may contribute to tumorigenesis in ovarian cancer .

Rsf-1／HBXAP基因在肿瘤发生发展中对基因扩增与染色质调节起一定的作用。

Epigenetic mechanisms , including DNA methylation , histone modification and chromatin remodeling , have been demonstrated to be involved in the development of SLE .

表观遗传学涉及的机制主要包括DNA甲基化和组蛋白修饰及染色质重塑。

This paper expounds classifies of ATP - dependent chromatin remodeling complex and its effects and roles , introduces chromatin remodeling complex take participates in gene transcription activities .

阐述了依赖ATP的染色体改构复合物的分类及对基因转录的影响和作用，并介绍了复合物的参与的转录活动。

Chromatin remodeling is an integral part of the process involved in gene transcriptional regulation . Chromatin remodeling is achieved through ATP dependent physical modifications and covalent chemical reactions .

染色质重塑是基因表达调控过程中一个非常重要的环节.染色质重塑主要包括2种类型：一种是依赖ATP的物理修饰，另一种是依赖共价结合反应的化学修饰。

The ING gene family is one of the most conservative gene families . Its functions are associated with chromatin remodeling , gene transcription , cell-cycle regulation , cell proliferation and apoptosis .

ING基因最早是通过消减杂交寻找抑癌基因的方法得到的，这个基因家族在进化中十分保守，功能上与染色质结构的调节、基因转录、细胞周期调控、细胞增殖以及细胞凋亡有关。

Chromatin remodeling complexes can be classified into four groups : SWI / SNF , ISWI , Mi-2 and DOMINO .

真核生物的染色质重构复合物至少可分为4类：SWI／SNF类，ISWI类，Mi-2类和DOMINO类，它们对染色质的重构都依赖于ATP的水解。

The expression of these chromatin remodeling factors parallels with SP1 and TBP spatially and temporally , suggesting that remodeling factors play an important role in chromatin structure and function during early development .

这些染色质重塑因子和转录因子TBP和SP1在小鼠胚胎中时间和空间上的表达是相一致的，说明了这些染色质重塑因子在早期发育过程中对染色质结构和功能起着重要作用。

The nature of chromatin remodeling , the role of histone acetyltransferase and deacetylase , the repression mechanisms of chromatin induced by the methylated CpG binding proteins are discussed in this paper .

本文讨论染色质动态调整的本质、组蛋白乙酰基转移酶和去乙酰基酶的作用、以及通过甲基化CpG结合蛋白而产生对染色质结构影响的机制等。

As a transcription elongation factor , it plays important roles in recruiting chromatin remodeling proteins , and in modulating chromatin structure by acetylating the highly conserved lysine residues in N-terminal tails of histones .

通过乙酰化特异染色质区组蛋白尾部的赖氨酸残基，Elp3参与特异染色质区结构的改变，为染色质结构调控蛋白提供识别信号，在转录延伸中发挥重要的作用。

We focused on BAF chromatin remodeling complex and and its signal pathway , analyzed the gene expression changes of BAF chromatin remodeling related genes , their downstream Wnt signaling and heart development key genes at the RNA and protein levels .

选取BAF染色质重塑复合物及其信号途径为研究对象，从RNA以及蛋白水平验证分析BAF染色质重塑相关基因及其下游Wnt信号和部分心脏发育关键基因的表达变化。

By double-labeling immunoelectron microscopy and immunoprecipitation assay , further illustrated that actin is a composition of chromatin remodeling complex BAF , and participates in transcription initiation activities together with transcriptional factor NF1 / CTF by RNA polymerase ⅱ .

通过免疫电镜和免疫共沉淀实验，证实了肌动蛋白是染色体改构复合物BAF的组成部分，和转录因子NF1/CTF参加了由RNA聚合酶II介导的基因转录活动。

In the past few fears , there has been a nascent convergence of scientific understanding of human disease with epigenetic . Identified epigenetic processes involved in human disease include chromatin remodeling , genomic imprinting , X chromosome inactivation , and noncoding RNAs regulation .

在过去的几年里，人们对表观遗传疾病的机理有了新的认识，这些疾病与染色质重塑、基因组印记、X染色体失活以及非编码RNA调控这4个表观遗传过程相关。

Recent reports have shown that in gene transcription , nuclear actin plays a key role as a component of chromatin remodeling complexes , transcription pre-initiation complex and messenger RNP ( mRNP ) particles associated with all three eukaryotic RNA polymerases ( pol ) .

近期实验报道，在基因的转录过程中，细胞核肌动蛋白分别作为染色质改构复合物，转录前起始复合物和信使核糖核蛋白的组分参与了3种真核生物RNA聚合酶的转录调控。

We first find that PTEN can be involved in chromatin remodeling , the function depends on the PTEN protein phosphatase activity of amino-terminal , C terminal ( incluing C2 domain , PDZ domain and C2 + PDZ ) could be an inhibitor in chromation remodeling .

首次发现PTEN可以参与染色质重塑，该功能依赖于PTEN蛋白氨基端的磷酸酶活性，C末端（C2结构域、PDZ结构域和C2+PDZ）有抑制作用。

Histone variants are the special chromosome histone types required for chromatin assembly at specific chromosome region , and it can replace the conventional histone via chromatin remodeling to exercise its function to regulate gene transcription under epigenetic level .

组蛋白变体是特殊状态下染色体组装所需的组蛋白类型，一般通过替换常规组蛋白导致染色体重塑进入核小体，能在表观遗传学水平调控基因的转录。