centrosome

New Progress of Research on Regulation of the Centrosome of Breast Cancer Cells

乳腺癌细胞中心体调控研究新进展

A Simulation Model of Centrosome and Chromosome in Cell Division

细胞分裂中中心体与染色体的仿真模型

The Experimental Study on the Correlation between Centrosome Hypertrophy and Esophageal Carcinoma

中心体异常和食管癌发生相关性的实验研究

This study is to investigate the relationship between centrosome and telomerase from the following three aspects .

本研究拟从三方面研究中心体与端粒酶的相关性：首先，研究中心体在乳腺癌发生中的动态变化，初步揭示其在癌发生中的作用；

Centrosome Study in Breast Tumor Cells

乳腺肿瘤细胞中心体研究

BACKGROUND & AIM : Centrosome is a small cellular organelle .

背景与目的：中心体（centrosome）是一个微小的细胞器。

Research Progress on Centrosome Abnormality Associated Genes in Oncology

中心体异常相关基因的肿瘤学研究进展

The study of regulation mechanism about centrosome replication can play an important role in early diagnosis and treatment of tumor .

研究中心体复制调控机制，对肿瘤的早期诊断和治疗有重要的作用。

Effect of Centrosome Abnormalities in CDDP Cytotoxicity Enhanced by Caffeine in Human Liver Cancer Cell Line

中心体异常在咖啡因增强顺铂杀伤人肝癌细胞系中的作用

Inhibitory Effection and Mechanism of p53 Gene on Centrosome Abnormality in Leukemia Cell Line K562

抑癌基因p53对白血病K562细胞中心体异常的抑制作用及其机制

Centrosome amplification and over-expression of P53 protein in esophageal carcinoma

中心体异常及P53蛋白过表达在食管癌变过程中的作用

Centrosome is the major microtubule ( MT ) - organizing center in animal cells .

在动物细胞中中心体是微管组织的主要细胞器。

With development of the research , the complicated function of centrosome and its im-portance have gradually been realized .

随着研究的进展，人们不断认识到中心体的复杂功能及其重要性。

Replication and Regulation of Cell Centrosome

细胞中心体的复制与调控

Regulation of Nek kinase family to centrosome and its correlation with tumorigenesis

Nek家族对中心体的调节作用及其与肿瘤发生的关系

Many centrosome - related proteins and kinases have been found to regulate different steps of centrosome duplication .

现已发现了许多中心体蛋白及与中心体复制相关的蛋白激酶，调控着中心体复制的各个步骤。

Any aberration in centrosome numbers can interfere with bipolar spindle formation and chromosome segregation .

纺锤体数目的异常直接干扰了双极纺锤体的形成以及染色体的分离过程。

Chromosome Abnormalities , Centrosome Amplification , and Telomere Dysfunction in Head and Neck Squamous Cell Carcinomas

染色体畸变、中心体扩增、端粒功能失调在头颈部鳞状细胞癌的研究和意义

Centrosome duplication is a key requirement for bipolar spindle formation and correct segregation of chromosomes during cell division .

中心体的正常复制对于细胞分裂时双极纺锤体的形成、染色体的正确分离是至关重要的。

Duplication of the centrosome is semiconservative and is coordinated with other cell cycle events , including DNA synthesis .

中心体复制过程与细胞核内其他事件相耦合，并与DNA复制一样，以半保留方式复制。

The roles of centrosome abnormality in the origination and development of cancers , especially in bladder transitional cell carcinoma are reviewed .

现就有关中心体异常在恶性肿瘤特别是膀胱移行细胞癌发生进展中的作用作一综述。

Therefore , centrosome duplication and segregation need to be tightly coordinated with the duplication and segregation of the genome .

因此在分裂细胞中，中心体的复制和分离必须与染色体的复制和分离过程相协调。

The major function of centrosome is as the major microtubule-organizing centres ( MTOCs ) of animal cells .

中心体的主要功能是作为主要的微管组织中心（microtubuleorganizingcentres，MTOCs）。

IntroductionThe centrosome is the major microtubule organizing center ( MTOC ) of mammalian cells .

中心体是哺乳类细胞主要的微管组织中心。

Abnormal centrosome can cause multipolar spindle formation , chromosome mis-segregation , and unequal distribution , and finally leads to cancers .

异常中心体可产生多极纺锤体，使染色体错误分离及分配不平衡，介导染色体不稳定性（CIN）和非整倍体的形成。

Centrosome comprise a pair of centrioles and pericentriolar material ( PCM ) .

中心体由一对中心粒（centrioles）和中心粒周围物质（Pericentriolarmaterial，PCM）组成。

This study is to study the roles of centrosome and telomerase in carcinogenesis , and explore the relationship between centrosome and telomerase in this process in particular .

本研究旨在探讨中心体与端粒酶在癌发生中的作用，特别是其相关性。

It was reported that HBXIP plays important roles in many cellular process , such as cell proliferation , apoptosis , mitosis , centrosome dynamics and cell cycle progression .

HBXIP在肿瘤细胞的增殖、有丝分裂、中心体动态和细胞周期进展中发挥重要作用。

A lot of factors can regulate the replication of centrosome including some cycle regulatory proteins and centrosomal proteins . oncogene . suppressor gene and their expression products .

中心体复制与细胞周期事件相耦合，许多细胞周期调节蛋白和中心体蛋白调节着中心体的复制，中心体复制还受癌基因和抑癌基因及其表达产物的调节。

OBJECTIVE To study the effect of centrosome on mutation and development of gene of laryngeal carcinoma by investigating centrosome expression and metaphase morphology in laryngeal squamous cell carcinoma cell lines .

目的通过对喉鳞状细胞癌（简称喉癌）细胞系中心体表达和细胞分裂形态的研究，探讨中心体通过对细胞分裂过程的调控，在促进喉癌基因不断变异、发展机制过程中的作用。