c1q

Effects of Complement C1q on the Growth and Collagen Synthesis of Gingival Fibroblasts

补体C1q对牙龈成纤维细胞作用的研究

Significance of Combination of Serum C1q Antibody and Interleukin-18 in Systemic Lupus Erythematosus

联合检测血清中C1q抗体、IL-18对系统性红斑狼疮的诊断价值

Molecular Identification , Functional Characterization and the Evolution Analysis of the Complement Component C1q and Immunoglobulin Genes in Teleosts

硬骨鱼类补体关键因子C1q及免疫球蛋白分子克隆、进化和功能的初步研究

Preparation of antibody to C1q by using euglobulin as immunogen

用优球蛋白作免疫原制备抗人C1q抗体

Result : 1.The expression of complement C1q and complement C3d protein is not observed in normal brain tissue .

结果：1.在正常脑组织中未发现补体C1q和C3d蛋白的阳性表达。

C1q , a subunit of C1 , has the ability to regulate the reaction of several types of cells .

补体分子C1q具有调节各种细胞反应的能力。

Conclusion To determine the normal value of IgM / C1q TCIC should take the age and sex into account .

结论确定IgM/C1qTCIC正常值应考虑年龄、性别因素的影响。

The data provide the first direct evidence that there is a connection between the C1q / C1qR system and the cytokine network .

这些资料揭示了C1q／C1qR系统的一项新功能，提供了该系统与细胞因子网络联系的直接证据。

IgM / C1q TCIC detected in healthy individuals could reflect the particular feature of immune status in the normal bodies .

健康人IgM/C1qTCIC检测可以反映正常机体免疫状态的有关特点。

As the first component of complement classical pathway , C1q plays an essential role in recognizing pathogens and activating the whole complement system .

作为补体系统经典途径的启动分子，C1q在对病原微生物的识别和整个补体系统的激活中起着重要作用。

The complement ( C1q and C3d ) expression was positively correlated with brain edema and neurological deficit .

补体C1q和C3d的表达水平与脑水肿和神经功能缺失呈正相关。

IgM / C1q TCIC found in umbilical serum was suggested an important indicator of the congenital infection in foetus .

脐血中检出IgM/C1qTCIC可作为胎儿先天性感染的重要指标之一。

Analysis of Phylogenesis and Expression Patterns of C1q , C3 and G10 in Amphioxus and Zebrafish

文昌鱼和斑马鱼C1q、C3及G10的进化分析及基因表达的研究

Some scholars believe that c1q plays a toxic effect in AD : c1q can combine with A beta peptide and promote the nucleation process of senile plaques .

部分学者认为clq在AD发病中起着毒性作用：clq通过与Ap多价结合，促进老年斑的成核过程。

Objective To explore the concentration and immunity biological significance of IgM and C1q two component circulating immune complexes ( IgM / C1q TCIC ) in healthy individuals .

目的确定健康人IgM激活C1q类双特异性循环免疫复合物的水平（IgM/C1qTCIC）并探讨其免疫生物学意义。

After the specific binding of antibody and antigen , the combination between its Fc fragment and Fc receptor of immune cells & C1q complement would be activated and strengthened .

当抗体与抗原特异结合后，其Fc段与免疫细胞Fc受体、C1q补体的结合得到了启动和加强。

Methods The level of complement C1q and C5 and C9 in twenty-five patients ( test group ) and twenty healthy subjects ( control group ) were detected by using the immunological method .

方法选择我院慢性肺心病患者25例（观察组），另选同期健康体检者20例（对照组），采用免疫比浊法测定两组患者血清补体C1q、C5、C9水平。

Conclusion A peptide with improved structural stability and inhibitory activities is obtained , which inhibits the binding of C1q to immune complex and blocks the activation of the classical complement pathway .

结论获得一个更具稳定结构和生物学活性的C1q结合短肽，它能更有效地抑制C1q与免疫复合物结合，从而阻断补体经典途径的激活。

The IC , which composed of hepatitis B virus e1 antigen ( HBeAg / 1 ), complement C1q and immunoglobulins , was found deposited in the elastic membrane of arteries .

IC由乙肝病毒e1抗原（HBeAg/1）、免疫球蛋白和补体C1q所组成，主要沉积在小动脉壁的弹力膜上；

Porcine C1q was purified from porcine serum by means of euglobulin precipitation by PEG , low ionic strength precipitation , IgG-Sepharose 4B affinity chromatography and Sephadex G-200 chromatography .

猪C1q由猪血清通过PEG沉淀优球蛋白、低离子强度透析沉淀、IgG－Sepharose48亲和层析、SephadexG－200凝胶层析等步骤分离纯化，每300ml血清可制得9.8mgC1q，产率为46.7%。

Method : The level of serum complement C1q in 76 patients with SLE ( 53 patients with active SLE , 23 patients with inactive SLE ) and in 30 normal controls were measured using single radial diffusion method .

方法：用单向免疫扩散法测定76例不同病情的SLE病人和30例健康人血清C1q水平，对部分活动期病人进行治疗前后动态观察。

Methods : Using immunohistochemical methods , the deposition of IgG , IgM , IgA , C3c , C4c , C1q and C4d was detected and double staining was performed in some specimens .

方法：采用免疫组化方法对淋巴组织标本进行IgG、IgM、IgA、C3c、C4c、C1q和C4d标记，同时对其部分标本进行双标染色。

Objective To study the relationship between C1q antibodies and disease activity as well as visceral involvement in patients with systemic lupus erythematosus ( SLE ), and analyze the influence of C1q antibodies to treatment and prognosis of SLE .

目的研究C1q抗体与系统性红斑狼疮（SLE）病情活动和脏器损害的相关性，探讨C1q抗体对SLE疗效及预后的影响。

The positive expression of complement C1q and C3d protein appear at 6h after MCAO , reach the peak at 72h , decrease gradually after then , the expression is still higher than normal tissue at 120h .

脑组织缺血后补体C1q和C3d蛋白的阳性表达在脑组织缺血再灌注后6h开始出现，72h达高峰，以后逐渐降低，到120h仍有较高水平表达。

The sensitivity of C3b sensitized yeast cell agglutination test ( 03b SYCA ) was determined in 772 normal serum samples and was compared with PEG precipitation and C1q latex agglutination inhibition test in 66 cases .

用772例正常血清标本对C3b致敏酵母凝集试验（即C3bSYCA）的敏感度进行了测定，并用66例标本进行了本法与PEG沉淀法及C1q乳胶凝集试验的比较。

Part ⅲ Synaptic protein expression in Tau + / c1q - / - double transgenic miceBackground : Synapse lose is one of the early pathological changes in AD. The lose of hippocampal synapse can be observed in patients with mild cognitive impairment ( MCI ) .

第三部分Tau+/clq-/-双转基因小鼠海马组织突触蛋白表达检测背景：突触受损是AD早期的病理变化之一。在轻度认知功能障碍（MCI）患者中即可观察到海马突触数量减少。