aiha

Analysis of AIHA with Positive Acidified Glycerol Lysis Test

酸化甘油溶解试验阳性的自身免疫性溶血性贫血实验指标分析

Objective To study the clinical characteristics of autoimmune hemolytic anemia ( AIHA ) with both warm and cold autoantibodies .

目的了解近十年温冷双抗体型自身免疫性溶血性贫血（AIHA）患者的临床特征，以加深对该病的认识。

Conclusion : ABO and Rh blood group identification of patients with AIHA can be interfered with by autoantibodies .

结论：AIHA患者自身抗体干扰ABO、Rh血型鉴定。

Objective To evaluate the clinical implications of IgG subclass in autoimmune hemolytic anemia ( AIHA ) .

目的研究温抗体型自身免疫性溶血性贫血IgG亚型及其临床意义。

Objective To analyse the relapse rate and risk factors of autoimmune hemolytic anemia ( AIHA ) and Evans syndrome .

目的了解自身免疫性溶血性贫血（AIHA）和Evans综合征复发率及其相关因素。

It is indicated that AIHA may be a multiple system disease induced by the abnormality of immune system , which results in RBC hemolysis .

认为AIHA可能是一种免疫紊乱导致以红细胞破坏为突出表现的多系统疾病。

Methods : Reviewing the literature of treatment of AIHA in and abroad , then initially concluding and recapitulating .

方法：复习国内外有关自身免疫性溶血性贫血治疗的文献，作一初步总结、综述。

Aim : To study the effect of autoantibody of patients with autoimmune hemolytic anemia ( AIHA ) on identification of ABO and Rh blood group .

目的：研究自身免疫溶血性贫血（AIHA）患者自身抗体对ABO及Rh血型定型的干扰。

Objective To distinguish types of the direct antiglobulin test ( DAT ) positive , help clinical to diagnose exactly the Autoimmune Hemolytic Anemia ( AIHA );

目的通过直接抗人球蛋白试验（DAT）阳性的类型鉴别，有助于临床对自身免疫性溶血性贫血（AIHA）的正确诊断；

Results The total relapse rate of these AIHA and Evans syndrome patients was 57.7 % , and the median remission duration to the first relapse was 9 months .

结果总复发率为57.7%；首次复发中位时间为缓解后9个月；

It is argues that AIHA roots from spleen and kidney deficiency , and exhibits the internal accumulation of dampness , heat , blood stasis and toxin ;

认为该病的中医病机特点是脾肾亏虚，湿、热、瘀、毒内伏，本虚标实，虚实夹杂；

If AIHA patient is transfused with red ceils carrying antigen which is corresponding to his autoantibodies , hemolysis will be seriously aggravated .

若给aiha患者输入携有与其自身抗体相对应的抗原的红细胞，则溶血更为严重。

To observe the therapeutic effect and safety of rituximab ( anti-CD20 monoclonal antibody ) in the treatment of refractory autoimmune hemolytic anemia ( AIHA ) .

本研究初步观察抗CD20单克隆抗体利妥昔（rituximab）用于治疗难治性自身免疫性溶血性贫血（AIHA）的疗效和安全性。

Results the elution liquid of AIHA group all reacts with standard antibody screen cell , it is all negative in non AIHA group except a SLE patient 's sample .

结果AIHA组患者的放散液均同标准抗体筛查细胞反应，非AIHA组除了1例SLE患者外均为阴性反应。

Objective To study the significance of the micro blood sample for surface antibody of red blood cells ( RBC ) in the diagnosis of childhood autoimmune hemolytic anemia ( AIHA ) .

目的采用微量血检测自身免疫性溶血性贫血（AIHA）患儿的红细胞表面抗体，对其方法学与诊断学进行探讨。

The percentage of CD55 - / CD59-on erythrocyte and neutrophil in MA and AIHA patients were all less than 5 % .

但中性粒细胞CD55-、CD59-百分率均<5%。

Objective : To compare the effects of classical Coombs test , modified Coombs test and modified Coombs test with monoclonal antibodies in the diagnosis of autoimmune hemolytic anemia ( AIHA ) .

目的：比较经典Coombs试验、改良Coombs试验、单抗Coombs分型试验，寻找更灵敏的方法诊断自身免疫性溶血性贫血（AIHA）。

Methods The blood samples of 23 patients with AIHA were identified by routine typing and typing after chloroquine elution test on DIANA auto instrument . Direct and indirect antiglobulin test were done in the same time .

方法用DIANA全自动血型仪对23例AIHA患者进行ABO、Rh（D）血型常规定型及氯喹放散实验后定型，同时进行直、间接抗人球蛋白试验。

Objective : To study the therapeutic and effect of autologous peripheral blood stem cell transplantation ( APBSCT ) in combination with anti-CD20-monoclonal antibody ( rituximab ) on autoimmune hemolytic anemia ( AIHA ) .

目的：探讨自体外周血干细胞移植（autologousperipheralbloodstemcelltransplantation，APBSCT）联合抗CD20单克隆抗体利妥昔单抗治疗自身免疫性溶血性贫血（autoimmunehemolyticanemia，AIHA）的疗效。

Rh blood group system is the most polymorphic system of the human red cell blood groups having great significance in clinical transfusion , hemolytic disease of the newborn ( HDN ) and autoimmune hemolytic anemia ( AIHA ) .

Rh血型系统是最具多态性的红细胞血型系统，在临床输血、新生儿溶血病和自身免疫性溶血性贫血中具有重要意义。

Conclusions AIHA with both warm and cold autoantibodies is related with the type and thermal amplitude of the autoantibody and the activation of complement . It can be treated effectively with combined immunosuppressive therapy , but the relapse rate is high .

结论温冷双抗体型AIHA是一种女性多见、原发性为主、与抗体种类和温幅及补体激活相关、复发率较高的溶血性疾病，联合免疫抑制治疗效果较好。

The results showed that out of 38 patients with AIHA , 11 cases ( 31.6 % ) of ABO blood group were difficultly typed , indirect antiglobulin test were positive , and contradiction between cells typing and sera typing were observed .

结果表明：38例AIHA患者中，ABO血型难定者11例（31.6%），均为间接抗球蛋白试验阳性及正反定型不合。

The result of blood type specificity determination with ether elution method reported in this paper showed that in the series of 50 cases of AIHA , 7 cases had relative specificity including anti-D ( 1 case ), anti-E ( 2 cases ) and anti-e ( 4 cases ) .

本组50例AIHA患者自身抗体经血型抗原特异性鉴定（乙醚冼脱法），发现7例具有相对特异性，其中抗D1例，抗E2例，抗e4例。

Methods DAT positive samples can be divided into AIHA group and non AIHA group , process immunity types , and test the samples of IgG or IgG + C 3 with elution , use elution liquid and standard antibody screen cell to process indirect antiglobulin test ( IAT ) .

方法DAT阳性标本分AIHA组和非AIHA组，进行免疫分型，然后把IgG或IgG+C3的标本进行放散试验，利用放散液与标准抗体筛查细胞进行间接抗人球蛋白试验（IAT）。

IRAT method could be used in blood matching blood grouping aud in testing the IgG for anti-A and anti-B. Preliminary comparative observations of testing for incomplete antibody in patients with AIHA by IRTA and immediate Coombs test gave basically consistent results ( Original article on page 9 )

IRAT法可用于配血、分型、检测IgG抗-A，抗-B等。还用IRAT法和直接Coombs试验对AIHA惠者的检出做了初步对比观察，结果基本一致。